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NCT06671977 · ClinicalTrials.gov registry record · Phase 1
Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans
A Phase 1 study of Depression and Major Depression Disorder, sponsored by Deepak C. D'Souza.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06671977: Recruiting Phase 1 study of Depression and Major Depression Disorder, sponsored by Deepak C. D'Souza.
NCT06671977 is a Phase 1 study of Depression and Major Depression Disorder that is actively recruiting participants, run by Deepak C. D'Souza. The registered enrollment target is 60 participants, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06671977, a Phase 1 study of Depression and Major Depression Disorder, is actively recruiting participants, sponsored by Deepak C. D'Souza.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this phase 1 study is to investigate the safety and efficacy of dimethyltryptamine (DMT) in individuals with depression and healthy controls. We hypothesize that administration of DMT will result in decreases in depression, associated symptoms, and neuroplastic changes in depressed subjects. We expect that DMT will induce changes in neuroplasticity as indexed using electroencephalographic (EEG) measures and tasks in both depressed individuals and healthy volunteers, though to different degrees. These neuronal changes may in parallel cause changes in mood measured both in healthy and depressed subjects, which will be captured using appropriate psychometric measures of mood.
Primary Outcome
Pulse oximetry will be measured continuously.
Conditions Studied
Interventions
- DRUG DMT-Medium Dose
- DRUG DMT-Low Dose
- DRUG THC-Medium Dose
- DRUG THC-Low Dose
Study Locations (1)
Connecticut
- Biological Studies Unit at the VA Connecticut Healthcare System, Yale School of Medicine, - West Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2025-03-14 |
| Est. Completion | 2027-12-01 |
| Phase | Phase 1 |
What NCT06671977 shows while recruiting
NCT06671977 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 786-participant average among 679 other Depression trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Depression appearing as the primary indexed condition, and to 4 interventions - of which DMT-Medium Dose is the first listed.
NCT06671977 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06671977 about?
NCT06671977 is a clinical study titled "Study of the Safety, Tolerability, Electrophysiological Effects and Efficacy of DMT in Humans". The goal of this phase 1 study is to investigate the safety and efficacy of dimethyltryptamine (DMT) in individuals with depression and healthy controls. We hypothesize that administration of DMT will result in decreases in depression, associated symptoms, and neuroplastic changes in depressed subje...
What is the current status of trial NCT06671977?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2025-03-14. Estimated completion is 2027-12-01.
What conditions does trial NCT06671977 study?
This clinical trial studies the following conditions: Depression, Major Depression Disorder.
What interventions are being tested in trial NCT06671977?
The interventions under investigation include: DMT-Medium Dose (DRUG), DMT-Low Dose (DRUG), THC-Medium Dose (DRUG), THC-Low Dose (DRUG).
Who is sponsoring clinical trial NCT06671977?
This trial is sponsored by Deepak C. D'Souza, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06671977 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06671977's enrollment target sits among peer trials
60 428th of 679 higher than 234 of 679 other Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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