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ClinicalTrials.gov 33 recruiting now official registry

Congenital Heart Disease clinical trials

33 of 64 indexed Congenital Heart Disease trials are currently recruiting.

64 US clinical trials · 33 currently recruiting

Congenital Heart Disease is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Boston Children's Hospital, running 9 of these trials.

The research picture

Congenital Heart Disease has 64 registered US clinical trials, 33 of them open to new participants right now, about 52% of the total.

33
recruiting participants now
52%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
9
top sponsor: Boston Children's Hospital
Phase 13Phase 21Phase 33

Active & Recent Trials

64 total, page 1 of 2

RECRUITING 1,000 participants

Genetics of Congenital Heart Disease

Nationwide Children's Hospital

NCT01192048

RECRUITING NA 1,000 participants

Improving Congenital Heart Disease Care

University of California, San Francisco

NCT06581484

RECRUITING 1,000 participants

Development of CIRC Technologies

The Cleveland Clinic

NCT05654272

RECRUITING 600 participants

Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

Emory University

NCT00243776

RECRUITING 500 participants

The Co-Op @ HeartWorks

HeartWorks

NCT06469918

RECRUITING 400 participants

Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry

Leiden University Medical Center

NCT06932081

RECRUITING 300 participants

ATrial Tachycardia PAcing Therapy in Congenital Heart

Ian Law

NCT03209583

RECRUITING 300 participants

IPSC Repository of Pediatric Cardiovascular Disease

Mingtao Zhao

NCT05550324

RECRUITING 300 participants

Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases

Mayo Clinic

NCT05122962

RECRUITING NA 225 participants

The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults

Boston Children's Hospital

NCT05258981

RECRUITING NA 200 participants

Fontan Fitness Trial

Children's Hospital of Philadelphia

NCT06918795

RECRUITING NA 200 participants

The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study

Scripps Translational Science Institute

NCT06244940

RECRUITING NA 200 participants

A Study of Hemodynamic Cardiopulmonary Exercise for CHD

Mayo Clinic

NCT06566196

RECRUITING 200 participants

Effect of Fetal Aortic Valvuloplasty on Outcomes

Queen Silvia Children's Hospital, Gothenburg, Sweden

NCT05386173

RECRUITING NA 200 participants

HFNC vs NIPPV Following Extubation

Emory University

NCT05869825

RECRUITING NA 150 participants

Blood Conservation in Patients (3.5-12kg) Undergoing Congenital Cardiac Surgery

Augusta University

NCT05881564

RECRUITING 100 participants

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT05213598

RECRUITING NA 100 participants

Ventripoint Single Ventricle Study

Duke University

NCT05262907

RECRUITING 100 participants

Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery

Boston Children's Hospital

NCT04299828

RECRUITING 92 participants

Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)

Icahn School of Medicine at Mount Sinai

NCT06575270

RECRUITING 50 participants

A Study of Invasive Hemodynamic for MACHD Registry

Mayo Clinic

NCT05849025

RECRUITING 50 participants

Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables

The Cleveland Clinic

NCT06818760

RECRUITING 50 participants

Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease

Boston Children's Hospital

NCT05241418

RECRUITING Phase 2 50 participants

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

Stanford University

NCT06080074

RECRUITING Phase 1 50 participants

Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease

HeartWorks

NCT05647213

RECRUITING Phase 1 50 participants

Propranolol Treatment for Postoperative Chylothorax

June Wu

NCT06833320

RECRUITING 45 participants

PDA for Kidneys Study

University of Wisconsin, Madison

NCT06658496

RECRUITING Phase 3 45 participants

Effect of Sacubitril-Valsartan on Cardiac Structure and Function

Mayo Clinic

NCT06693674

RECRUITING NA 40 participants

Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents

Children's Hospital Los Angeles

NCT07023367

RECRUITING NA 36 participants

Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment

Columbia University

NCT03891160

RECRUITING NA 35 participants

Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

Starlight Cardiovascular

NCT07114718

RECRUITING 30 participants

Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise

Medical College of Wisconsin

NCT03775954

RECRUITING 10 participants

Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

Boston Children's Hospital

NCT06434207

ACTIVE NOT RECRUITING 5,000 participants

Technical Development for Pediatric Cardiovascular MRI

Children's National Research Institute

NCT02892136

ACTIVE NOT RECRUITING 330 participants

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

Boston Children's Hospital

NCT05687292

ACTIVE NOT RECRUITING NA 150 participants

Harmony TPV Post-Approval Study

Medtronic Cardiovascular

NCT05077774

ACTIVE NOT RECRUITING Phase 3 144 participants

Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT

Carelon Research

NCT04702373

ACTIVE NOT RECRUITING NA 135 participants

Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making

University of Utah

NCT04437069

ACTIVE NOT RECRUITING NA 86 participants

The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study

Medtronic Heart Valves

NCT02979587

ACTIVE NOT RECRUITING NA 86 participants

ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent

Edwards Lifesciences

NCT03130777

ACTIVE NOT RECRUITING NA 51 participants

Autus Valve Pivotal Study

Autus Valve Technologies

NCT05006404

ACTIVE NOT RECRUITING NA 36 participants

Pediatric Adhesion and New Dermal Approach Study

iRhythm Technologies

NCT07118124

ACTIVE NOT RECRUITING NA 33 participants

Peer Coaching Intervention in Young Adults With Congenital Heart Disease

Duke University

NCT04271358

COMPLETED 8,415 participants

Assessment of Patterns of Patient Reported Outcomes in Adults With Congenital Heart Disease - International Study II

KU Leuven

NCT04902768

COMPLETED 6,147 participants

The Impact of Implementing a Universal Newborn Screening for Critical Congenital Heart Disease

Pediatrix

NCT01749059

COMPLETED 273 participants

Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)

Carelon Research

NCT05312177

COMPLETED NA 218 participants

Transitional Telehealth Home Care: REACH

Children's Hospital of Philadelphia

NCT01941667

COMPLETED 200 participants

Transverse Thoracic Plane Block in the Pediatric Cardiac Patient

Ochsner Health System

NCT04138745

COMPLETED NA 180 participants

Evaluation of Web-based Transition Education to Enhance Transition Readiness

University of Michigan

NCT03303248

COMPLETED 146 participants

Clinical Characteristics and Associations of the "Good Fontan" Patient

Boston Children's Hospital

NCT03470428

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Congenital Heart Disease Trial Landscape

64 indexed Congenital Heart Disease studies · 33 recruiting (52%).

Phase mix: 3 late (III/IV) vs 4 early (I/II).

Top sponsor: Boston Children's Hospital (9 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Congenital Heart Disease?

PlainTrial tracks 64 US clinical trials for Congenital Heart Disease, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Congenital Heart Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.