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Congenital Heart Disease: full-pipeline trial registry
33 of 64 indexed Congenital Heart Disease trials are currently recruiting.
Corpus placement: #215 of 28,707 conditions by registered trial count.
64 US clinical trials · 33 currently recruiting · #215 of 28,707 conditions by registered trial count
Congenital Heart Disease: 64 US clinical trials tracked, 33 recruiting.
Congenital Heart Disease is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Boston Children's Hospital, running 9 of these trials.
Enrollment posture brief
Registry condition congenital-heart-disease
OPEN 33 | RECR 52% | LATE 3 | EARLY 4 | RANK #215 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Cutaneous Melanoma (52% recruiting · 31 trials)
Congenital Heart Disease lists 33 open slots (52% of 64 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Congenital Heart Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Congenital Heart Disease is recruiting above its size-band peers.
33 of 64 indexed trials (51.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Congenital Heart Disease trials is spread across many organizations.
Boston Children's Hospital accounts for 9 of 64 trials (14.1%). 42 distinct sponsors appear on at least one study for this condition label.
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Typical Congenital Heart Disease enrolment sits around 92 participants.
Median target enrolment is 92 among the 64 trials that report a genuine target (sentinel values excluded). 33 of those (51.6%) plan for fewer than 100 participants.
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Congenital Heart Disease splits between interventional and observational designs.
34 interventional and 30 observational studies make up this index (53.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
64 total, page 1 of 2
Genetics of Congenital Heart Disease
Nationwide Children's Hospital
NCT01192048
Improving Congenital Heart Disease Care
University of California, San Francisco
NCT06581484
Development of CIRC Technologies
The Cleveland Clinic
NCT05654272
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
Emory University
NCT00243776
The Co-Op @ HeartWorks
HeartWorks
NCT06469918
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
Leiden University Medical Center
NCT06932081
ATrial Tachycardia PAcing Therapy in Congenital Heart
Ian Law
NCT03209583
IPSC Repository of Pediatric Cardiovascular Disease
Mingtao Zhao
NCT05550324
Pathophysiologic Mechanism for Arrhythmias and Impaired Aerobic Capacity in Tetralogy of Fallot and Other Congenital Heart Diseases
Mayo Clinic
NCT05122962
The Relationship Between Brain MRI Phenotypes, Genes and Cognitive Outcome in CHD Adults
Boston Children's Hospital
NCT05258981
Fontan Fitness Trial
Children's Hospital of Philadelphia
NCT06918795
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study
Scripps Translational Science Institute
NCT06244940
A Study of Hemodynamic Cardiopulmonary Exercise for CHD
Mayo Clinic
NCT06566196
Effect of Fetal Aortic Valvuloplasty on Outcomes
Queen Silvia Children's Hospital, Gothenburg, Sweden
NCT05386173
HFNC vs NIPPV Following Extubation
Emory University
NCT05869825
Blood Conservation in Patients (3.5-12kg) Undergoing Congenital Cardiac Surgery
Augusta University
NCT05881564
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT05213598
Ventripoint Single Ventricle Study
Duke University
NCT05262907
Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
Boston Children's Hospital
NCT04299828
Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
Icahn School of Medicine at Mount Sinai
NCT06575270
A Study of Invasive Hemodynamic for MACHD Registry
Mayo Clinic
NCT05849025
Remote Monitoring in Pregnant Women With Congenital Heart Disease Using Wrist Wearables
The Cleveland Clinic
NCT06818760
Atrial Late Gadolinium Enhancement in Patients with Repaired Congenital Heart Disease
Boston Children's Hospital
NCT05241418
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
Stanford University
NCT06080074
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease
HeartWorks
NCT05647213
Propranolol Treatment for Postoperative Chylothorax
June Wu
NCT06833320
PDA for Kidneys Study
University of Wisconsin, Madison
NCT06658496
Effect of Sacubitril-Valsartan on Cardiac Structure and Function
Mayo Clinic
NCT06693674
Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents
Children's Hospital Los Angeles
NCT07023367
Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment
Columbia University
NCT03891160
Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
Starlight Cardiovascular
NCT07114718
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
Medical College of Wisconsin
NCT03775954
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Boston Children's Hospital
NCT06434207
Technical Development for Pediatric Cardiovascular MRI
Children's National Research Institute
NCT02892136
Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
Boston Children's Hospital
NCT05687292
Harmony TPV Post-Approval Study
Medtronic Cardiovascular
NCT05077774
Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT
Carelon Research
NCT04702373
Improving Patient and Family Health Using Family-Centered Outcomes and Shared Decision-Making
University of Utah
NCT04437069
The Medtronic Harmony™ Transcatheter Pulmonary Valve Clinical Study
Medtronic Heart Valves
NCT02979587
ALTERRA: SAPIEN 3 THV With the Alterra Adaptive Prestent
Edwards Lifesciences
NCT03130777
Autus Valve Pivotal Study
Autus Valve Technologies
NCT05006404
Pediatric Adhesion and New Dermal Approach Study
iRhythm Technologies
NCT07118124
Peer Coaching Intervention in Young Adults With Congenital Heart Disease
Duke University
NCT04271358
Assessment of Patterns of Patient Reported Outcomes in Adults With Congenital Heart Disease - International Study II
KU Leuven
NCT04902768
The Impact of Implementing a Universal Newborn Screening for Critical Congenital Heart Disease
Pediatrix
NCT01749059
Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
Carelon Research
NCT05312177
Transitional Telehealth Home Care: REACH
Children's Hospital of Philadelphia
NCT01941667
Transverse Thoracic Plane Block in the Pediatric Cardiac Patient
Ochsner Health System
NCT04138745
Evaluation of Web-based Transition Education to Enhance Transition Readiness
University of Michigan
NCT03303248
Clinical Characteristics and Associations of the "Good Fontan" Patient
Boston Children's Hospital
NCT03470428
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 1 |
| Phase 3 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Congenital Heart Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Congenital Heart Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Congenital Heart Disease page
64 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Congenital Heart Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Boston Children's Hospital sponsors the most Congenital Heart Disease trials on record, review their full trial history before evaluating a specific study. See Boston Children's Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Congenital Heart Disease condition card totals 64 registered trials; most-linked intervention Harmony TPV System; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.