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NCT06434207 · ClinicalTrials.gov registry record
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
A clinical trial of Congenital Heart Disease and Thrombosis, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 10
- Enrollment target
- 1
- Study location
NCT06434207: Recruiting study of Congenital Heart Disease and Thrombosis, sponsored by Boston Children's Hospital.
NCT06434207 is a study of Congenital Heart Disease and Thrombosis that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 10 participants, below the 474-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06434207, a study of Congenital Heart Disease and Thrombosis, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not well described. The goal of this proposal is to prospectively collect plasma samples from ten (10) neonates with antenatal diagnosis of severe congenital heart disease (CHD) to better understand mechanisms responsible for abnormal clotting in the perioperative period.
Primary Outcome
isolation, purification and sequencing of patterns of miRNA and clustering analysis will be performed to determine predominant populations of miRNA related to inflammation, complement activation, and coagulation among other pathways
Conditions Studied
Interventions
- OTHER Collecting discarded blood samples
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-10-31 |
| Est. Completion | 2026-12-01 |
What NCT06434207 shows while recruiting
NCT06434207 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 474-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Congenital Heart Disease appearing as the primary indexed condition, and to 1 intervention - of which Collecting discarded blood samples is the first listed.
NCT06434207 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06434207 about?
NCT06434207 is a clinical study titled "Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis". Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not w...
What is the current status of trial NCT06434207?
This trial is currently recruiting. The enrollment target is 10 participants. The study started on 2024-10-31. Estimated completion is 2026-12-01.
What conditions does trial NCT06434207 study?
This clinical trial studies the following conditions: Congenital Heart Disease, Thrombosis, Single-ventricle.
What interventions are being tested in trial NCT06434207?
The interventions under investigation include: Collecting discarded blood samples (OTHER).
Who is sponsoring clinical trial NCT06434207?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06434207 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congenital Heart Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06434207's enrollment target sits among peer trials
10 63rd of 63 the lowest of 63 other Congenital Heart Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Heart Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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