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NCT05654272 · ClinicalTrials.gov registry record
Development of CIRC Technologies
A clinical trial of Heart Failure and Cardiovascular Diseases, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT05654272: Recruiting study of Heart Failure and Cardiovascular Diseases, sponsored by The Cleveland Clinic.
NCT05654272 is a study of Heart Failure and Cardiovascular Diseases that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 1,000 participants, below the 2,047-participant average among 397 other Heart Failure trials with a reported enrollment target (51% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05654272, a study of Heart Failure and Cardiovascular Diseases, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow us the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. Our team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.
Primary Outcome
The primary clinical objective of the clinical study is to determine and compare cardiac microstructural phenotypes by cardiac MRI in patients and healthy controls
Conditions Studied
Interventions
- DIAGNOSTIC_TEST MRI
Study Locations (1)
Ohio
- Cardiovascular Innovation Research Center - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2022-09-09 |
| Est. Completion | 2042-09-09 |
What NCT05654272 shows while recruiting
NCT05654272 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, below the 2,047-participant average among 397 other Heart Failure trials with a reported enrollment target (51% lower).
The record links to 10 conditions, with Heart Failure appearing as the primary indexed condition, and to 1 intervention - of which MRI is the first listed.
NCT05654272 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT05654272 about?
NCT05654272 is a clinical study titled "Development of CIRC Technologies". Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing rad...
What is the current status of trial NCT05654272?
This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2022-09-09. Estimated completion is 2042-09-09.
What conditions does trial NCT05654272 study?
This clinical trial studies the following conditions: Heart Failure, Cardiovascular Diseases, Atrial Fibrillation, Congenital Heart Disease, Ischemic Heart Disease.
What interventions are being tested in trial NCT05654272?
The interventions under investigation include: MRI (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05654272?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05654272 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05654272's enrollment target sits among peer trials
1,000 67th of 397 higher than 325 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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