Children's Hospital of Philadelphia
Trial Pipeline
Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention
NCT07084129
CEUS Evaluation of Hydrocephalus in Neonates and Infants
NCT06693752
Urinary Titin Biomarker in DMD
NCT07332013
Sleep Promotion and Pediatric Hypertension
NCT06642246
Supraglottic Airway for Resuscitation Trial
NCT07150923
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG
NCT05555550
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
NCT07123961
Optimal Ventilation for Cardiac Arrest
NCT07114510
Physical Activity in CKD
NCT06624358
Examining the Efficacy of the PRAISE With Coaching Program
NCT07191782
Motivation for Daily Living Skills
NCT07159308
SMART Implementation-Effectiveness Trial 1
NCT07137923
SMART Implementation-Effectiveness Trial 2
NCT07138027
Re-Engaging AYA Survivors in Cancer-Related Healthcare
NCT07138040
Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia
NCT06534359
Fontan Fitness Trial
NCT06918795
Vancomycin Reduction Practices (VRP) in the NICU
NCT06772675
CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus
NCT06839976
ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia
NCT06364774
Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT
NCT06839456
Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
NCT07020572
Neurometabolic Profile of Individuals With Primary Mitochondrial Disease
NCT06890520
Massage Impact on Sleep in Pediatric Oncology
NCT06892158
Validation of Nanosensor Oxygen Measurement
NCT06819683
The Collaborative Care PrTNER Study
NCT06585631
Calculating Wall Shear Stress in Infant Pulmonary Veins
NCT06440408
Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network
NCT06582693
Driver Education Research Study
NCT06413927
18F-Fluciclovine PET-MRI in High-grade Glioma
NCT05553041
Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)
NCT06458036
iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH
NCT05442671
Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy
NCT06389994
Facilitating Access to Specialty Treatment
NCT05741411
Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer
NCT05783323
Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia
NCT06475976
Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas
NCT06156410
Neurophysiologic Biomarkers in Rett Syndrome
NCT05932589
Smart Checklist Implementation for Pediatric Tracheal Intubations in the ICU- Multicenter Study
NCT06085326
Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children
NCT05703347
STXBP1 and SYNGAP1 Related Disorders Natural History Study
NCT06555965
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
NCT05975671
Diet and Motility in IBS
NCT07283341
Lurbinectedin in FET-Fused Tumors
NCT05918640
Virtual Patient Navigation During a Pandemic
NCT06208852
Synovial Sarcoma Registry / Biospecimen Repository
NCT05910307
Optimizing Tracheal Intubation Outcomes and Neonatal Safety
NCT05838690
Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry
NCT06693778
Home Apnea Testing in CHildren Trial
NCT05382754
Applying pGz in Mitochondrial Disease
NCT05569122
Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors
NCT05194397
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
NCT04086329
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
NCT05673499
HOPS Study: A Conceptual Replication
NCT04465708
BSGM to Evaluate Patients With GI Symptoms
NCT05880199
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
NCT05024929
Fibrosis and the Fontan
NCT04901975
Sleep and Glycemic Control in Type 2 Diabetes Adolescents
NCT04213547
RH Genotype Matched RBC Transfusions
NCT04156893
Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study
NCT04338048
Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients
NCT04293042
Positive Parenting Program in Foster Care
NCT03910491
CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT
NCT03810196
Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria
NCT03301038
CEUS for Blunt Abdominal Trauma in Children
NCT03490929
Pencil Beam Scanning in Patients With Renal Tumors
NCT03810651
Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH
NCT03107520
Natural History Study of Mitochondrial Myopathy
NCT05250375
Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
NCT03419260
The Myelin Disorders Biorepository Project
NCT03047369
Quality of Pediatric Resuscitation in a Multicenter Collaborative
NCT02708134
Evaluation of Outcome Metrics in Alexander Disease
NCT02714764
Fludarabine Based RIC for Bone Marrow Failure Syndromes
NCT02928991
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
NCT02356653
Genetics of Insulin and Incretins in Cystic Fibrosis
NCT01852448
ARPKD Database Study
NCT01401998
Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs
NCT02493478
Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care
NCT07217002
Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain
NCT05834725
BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches
NCT06187662
Fiber Food Introduction in Pediatric Short Bowel Syndrome
NCT05432648
Gastric Ultrasound in Pediatric Trauma Patients
NCT05330351
Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis
NCT04891640
Discharge Stewardship in Children's Hospitals
NCT05826873
Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes
NCT04238949
Reducing Disparities in Behavioral Health Treatment for Children in Primary Care
NCT04082234
Effectiveness of Contrast-Enhanced Ultrasound
NCT03473249
VIRTUUS Children's Study
NCT03719339
Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF
NCT03047746
Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies
NCT02990819
Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia
NCT02549820
Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies
NCT02323867
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders
NCT01050855
Caregiver Implementation Strategies Field Pre-Test
NCT06770036
Helping Educate and Advance Learning Through Healthy Bite-Sized Eating Strategies
NCT06082830
Xofluza-Wearables Feasibility-Study
NCT06161454
Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).
NCT06051448
Preserving Kidney Function in Children With Chronic Kidney Disease
NCT05169411
Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms: Impact on Child Development
NCT05400161
Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)
NCT05353998
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 160 |
| Phase 2 | 12 |
| Phase 3 | 6 |
| Phase 4 | 6 |
What the Pipeline for Children's Hospital of Philadelphia Shows
According to the ClinicalTrials.gov registry, Children's Hospital of Philadelphia is linked to 492 US clinical trials across every stage of research activity. Of those, 412 studies are currently recruiting — about 84% of the sponsor's indexed portfolio — and 63 are already marked complete, representing roughly 13% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
The phase mix for Children's Hospital of Philadelphia reports 12 late-stage studies (Phase 3 and Phase 4 combined) and 172 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
The top therapeutic focus area indexed for Children's Hospital of Philadelphia is Pediatric Cancer with 5 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology — how this data is sourced, computed, and verified.