Children's Hospital of Philadelphia

492 total trials 412 currently recruiting 63 completed

Trial Pipeline

RECRUITING Phase 1

Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

NCT07084129

RECRUITING Phase 2

CEUS Evaluation of Hydrocephalus in Neonates and Infants

NCT06693752

RECRUITING NA

Urinary Titin Biomarker in DMD

NCT07332013

RECRUITING NA

Sleep Promotion and Pediatric Hypertension

NCT06642246

RECRUITING NA

Supraglottic Airway for Resuscitation Trial

NCT07150923

RECRUITING Early Phase 1

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

NCT05555550

RECRUITING Phase 2

Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial

NCT07123961

RECRUITING NA

Optimal Ventilation for Cardiac Arrest

NCT07114510

RECRUITING NA

Physical Activity in CKD

NCT06624358

RECRUITING NA

Examining the Efficacy of the PRAISE With Coaching Program

NCT07191782

RECRUITING NA

Motivation for Daily Living Skills

NCT07159308

RECRUITING NA

SMART Implementation-Effectiveness Trial 1

NCT07137923

RECRUITING NA

SMART Implementation-Effectiveness Trial 2

NCT07138027

RECRUITING NA

Re-Engaging AYA Survivors in Cancer-Related Healthcare

NCT07138040

RECRUITING NA

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

NCT06534359

RECRUITING NA

Fontan Fitness Trial

NCT06918795

RECRUITING NA

Vancomycin Reduction Practices (VRP) in the NICU

NCT06772675

RECRUITING Phase 1

CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

NCT06839976

RECRUITING Phase 1

ALS20-101 Lentiviral Gene Therapy for Beta Thalassemia

NCT06364774

RECRUITING Phase 1

Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT

NCT06839456

RECRUITING NA

Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)

NCT07020572

RECRUITING

Neurometabolic Profile of Individuals With Primary Mitochondrial Disease

NCT06890520

RECRUITING NA

Massage Impact on Sleep in Pediatric Oncology

NCT06892158

RECRUITING Phase 1

Validation of Nanosensor Oxygen Measurement

NCT06819683

RECRUITING NA

The Collaborative Care PrTNER Study

NCT06585631

RECRUITING Phase 1

Calculating Wall Shear Stress in Infant Pulmonary Veins

NCT06440408

RECRUITING NA

Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

NCT06582693

RECRUITING NA

Driver Education Research Study

NCT06413927

RECRUITING Early Phase 1

18F-Fluciclovine PET-MRI in High-grade Glioma

NCT05553041

RECRUITING Phase 2

Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)

NCT06458036

RECRUITING NA

iTONE Trial (exercIse Training in pulmONary hypertEnsion) Exercise Program for Pediatric PH

NCT05442671

RECRUITING

Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy

NCT06389994

RECRUITING NA

Facilitating Access to Specialty Treatment

NCT05741411

RECRUITING Phase 2

Larotrectinib to Enhance RAI Avidity in Differentiated Thyroid Cancer

NCT05783323

RECRUITING

Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

NCT06475976

RECRUITING Phase 1

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

NCT06156410

RECRUITING

Neurophysiologic Biomarkers in Rett Syndrome

NCT05932589

RECRUITING NA

Smart Checklist Implementation for Pediatric Tracheal Intubations in the ICU- Multicenter Study

NCT06085326

RECRUITING NA

Optimizing a Mobile Health Platform for Sleep Promotion and Obesity Prevention in Children

NCT05703347

RECRUITING

STXBP1 and SYNGAP1 Related Disorders Natural History Study

NCT06555965

RECRUITING NA

Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis

NCT05975671

RECRUITING

Diet and Motility in IBS

NCT07283341

RECRUITING Phase 1

Lurbinectedin in FET-Fused Tumors

NCT05918640

RECRUITING NA

Virtual Patient Navigation During a Pandemic

NCT06208852

RECRUITING

Synovial Sarcoma Registry / Biospecimen Repository

NCT05910307

RECRUITING NA

Optimizing Tracheal Intubation Outcomes and Neonatal Safety

NCT05838690

RECRUITING

Utilizing Electronic Clinical Decision Support to Enhance mTBI Care at the Primary Care Point of Entry

NCT06693778

RECRUITING NA

Home Apnea Testing in CHildren Trial

NCT05382754

RECRUITING Phase 1

Applying pGz in Mitochondrial Disease

NCT05569122

RECRUITING Phase 2

Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

NCT05194397

RECRUITING Phase 1

Validation of Oxygen Nanosensor in Mitochondrial Myopathy

NCT04086329

RECRUITING

International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery

NCT05673499

RECRUITING NA

HOPS Study: A Conceptual Replication

NCT04465708

RECRUITING

BSGM to Evaluate Patients With GI Symptoms

NCT05880199

RECRUITING

Targeted Therapy to Increase RAI Uptake in Metastatic DTC

NCT05024929

RECRUITING Phase 1

Fibrosis and the Fontan

NCT04901975

RECRUITING NA

Sleep and Glycemic Control in Type 2 Diabetes Adolescents

NCT04213547

RECRUITING Phase 1

RH Genotype Matched RBC Transfusions

NCT04156893

RECRUITING

Autosomal Dominant Polycystic Kidney Disease (ADPKD) Study

NCT04338048

RECRUITING Early Phase 1

Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients

NCT04293042

RECRUITING NA

Positive Parenting Program in Foster Care

NCT03910491

RECRUITING NA

CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

NCT03810196

RECRUITING Phase 2

Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria

NCT03301038

RECRUITING Phase 4

CEUS for Blunt Abdominal Trauma in Children

NCT03490929

RECRUITING Early Phase 1

Pencil Beam Scanning in Patients With Renal Tumors

NCT03810651

RECRUITING Early Phase 1

Intraoperative Contrast-Enhanced Ultrasound Evaluation of Blood Flow at the Time of Surgical Hip Reduction for DDH

NCT03107520

RECRUITING

Natural History Study of Mitochondrial Myopathy

NCT05250375

RECRUITING

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

NCT03419260

RECRUITING

The Myelin Disorders Biorepository Project

NCT03047369

RECRUITING

Quality of Pediatric Resuscitation in a Multicenter Collaborative

NCT02708134

RECRUITING

Evaluation of Outcome Metrics in Alexander Disease

NCT02714764

RECRUITING Early Phase 1

Fludarabine Based RIC for Bone Marrow Failure Syndromes

NCT02928991

RECRUITING Early Phase 1

Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

NCT02356653

RECRUITING

Genetics of Insulin and Incretins in Cystic Fibrosis

NCT01852448

RECRUITING

ARPKD Database Study

NCT01401998

RECRUITING

Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

NCT02493478

ACTIVE NOT RECRUITING

Reducing Antibiotic Use by Implementation of Stewardship in Primary and Urgent Care

NCT07217002

ACTIVE NOT RECRUITING NA

Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain

NCT05834725

ACTIVE NOT RECRUITING NA

BrighT STAR LIBRA: Leveraging Implementation Science for Blood Culture Reduction Approaches

NCT06187662

ACTIVE NOT RECRUITING NA

Fiber Food Introduction in Pediatric Short Bowel Syndrome

NCT05432648

ACTIVE NOT RECRUITING

Gastric Ultrasound in Pediatric Trauma Patients

NCT05330351

ACTIVE NOT RECRUITING NA

Eliminating Monitor Overuse Trial (EMO Trial)

NCT05132322

ACTIVE NOT RECRUITING NA

Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis

NCT04891640

ACTIVE NOT RECRUITING NA

Discharge Stewardship in Children's Hospitals

NCT05826873

ACTIVE NOT RECRUITING NA

Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes

NCT04238949

ACTIVE NOT RECRUITING NA

Reducing Disparities in Behavioral Health Treatment for Children in Primary Care

NCT04082234

ACTIVE NOT RECRUITING Phase 4

Effectiveness of Contrast-Enhanced Ultrasound

NCT03473249

ACTIVE NOT RECRUITING

VIRTUUS Children's Study

NCT03719339

ACTIVE NOT RECRUITING NA

Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF

NCT03047746

ACTIVE NOT RECRUITING Phase 2

Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

NCT02990819

ACTIVE NOT RECRUITING NA

Fetoscopic Endoluminal Tracheal Occlusion in Severe Left Congenital Diaphragmatic Hernia

NCT02549820

ACTIVE NOT RECRUITING Phase 2

Allogeneic Stem Cell Transplant With Alpha/Beta T AND B Cell Depletion for Hematologic Malignancies

NCT02323867

ACTIVE NOT RECRUITING Phase 2

Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders

NCT01050855

COMPLETED NA

Caregiver Implementation Strategies Field Pre-Test

NCT06770036

COMPLETED NA

Helping Educate and Advance Learning Through Healthy Bite-Sized Eating Strategies

NCT06082830

COMPLETED Phase 4

Xofluza-Wearables Feasibility-Study

NCT06161454

COMPLETED Phase 1

Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).

NCT06051448

COMPLETED

Preserving Kidney Function in Children With Chronic Kidney Disease

NCT05169411

COMPLETED NA

Social Media-Based Parenting Program for Women With Postpartum Depressive Symptoms: Impact on Child Development

NCT05400161

COMPLETED NA

Efficacy of Clinical Decision Support and Sleep Navigation (Sleep PASS)

NCT05353998

What the Pipeline for Children's Hospital of Philadelphia Shows

According to the ClinicalTrials.gov registry, Children's Hospital of Philadelphia is linked to 492 US clinical trials across every stage of research activity. Of those, 412 studies are currently recruiting — about 84% of the sponsor's indexed portfolio — and 63 are already marked complete, representing roughly 13% of the total. Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

The phase mix for Children's Hospital of Philadelphia reports 12 late-stage studies (Phase 3 and Phase 4 combined) and 172 earlier-phase studies (Phase 1 and Phase 2). A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work — safety, dosing, and early signal detection — and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

The top therapeutic focus area indexed for Children's Hospital of Philadelphia is Pediatric Cancer with 5 linked trials, and 9 other condition areas appear in the top list above. That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice — verify current details directly with ClinicalTrials.gov before relying on any figure here.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial