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ClinicalTrials.gov 21 recruiting now official registry

Pulmonary Arterial Hypertension clinical trials

21 of 64 indexed Pulmonary Arterial Hypertension trials are currently recruiting.

64 US clinical trials · 21 currently recruiting

Pulmonary Arterial Hypertension is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 21 of them currently open to new participants. 18 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is Actelion, running 7 of these trials.

The research picture

Pulmonary Arterial Hypertension has 64 registered US clinical trials, 21 of them open to new participants right now, about 33% of the total.

21
recruiting participants now
33%
of trials open to enrollment
18
in Phase 3–4 (later-stage)
7
top sponsor: Actelion
Phase 16Phase 216Phase 37Phase 411

Active & Recent Trials

64 total, page 1 of 2

RECRUITING 10,000 participants

Rutgers University Study of the Genetics of Pulmonary Hypertension

Rutgers, The State University of New Jersey

NCT07217522

RECRUITING 5,000 participants

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Duke University

NCT04278404

RECRUITING 3,000 participants

Pulmonary Hypertension Association Registry

Pulmonary Hypertension Association

NCT04071327

RECRUITING 2,500 participants

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

New York Medical College

NCT02249923

RECRUITING Phase 3 815 participants

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

Merck Sharp & Dohme

NCT07218029

RECRUITING 300 participants

Pulmonary Hypertension Biorepository and Registry

University of Kansas Medical Center

NCT04808596

RECRUITING NA 100 participants

The MObile Health InterVEntion in Pulmonary Arterial Hypertension (MOVE PAH) Study

Vanderbilt University Medical Center

NCT05464095

RECRUITING Early Phase 1 71 participants

PET Image in PAH Patients

Stephen Y. Chan

NCT05452889

RECRUITING Phase 2 70 participants

Spironolactone for Pulmonary Arterial Hypertension

National Institutes of Health Clinical Center (CC)

NCT01712620

RECRUITING Phase 2 60 participants

Xenon MRI Pulm Hypertension

Bastiaan Driehuys

NCT04991454

RECRUITING Phase 2 60 participants

Repurposing Valsartan May Protect Against Pulmonary Hypertension

University of Washington

NCT06053580

RECRUITING NA 50 participants

Mobile Health Intervention to Improve Exercise in Pediatric PH

Vanderbilt University Medical Center

NCT06549452

RECRUITING NA 45 participants

A Study of Pulmonary Hypertension Peripheral Limitations

Mayo Clinic

NCT05968859

RECRUITING Phase 2 42 participants

Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

Merck Sharp & Dohme

NCT05587712

RECRUITING NA 30 participants

Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

Aria CV

NCT04555161

RECRUITING Phase 2 30 participants

Pulmonary Hypertension SOLAR

Bastiaan Driehuys

NCT04778046

RECRUITING Phase 1 24 participants

A Placebo-controlled, Randomized Clinical Trial to Assess the Safety, Feasibility, and Pharmacokinetics of Microbiota Transplant Therapy With Antibiotic Preconditioning and Fiber Supplementation in Patients With Pulmonary Arterial Hypertension

University of Minnesota

NCT06481852

RECRUITING Phase 3 20 participants

Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH

University of Arizona

NCT04062565

RECRUITING Phase 2 20 participants

129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

Bastiaan Driehuys

NCT06104228

RECRUITING NA 20 participants

Reducing Right Ventricular Failure in Pulmonary Arterial Hypertension (RELIEVE-PAH)

V-Wave

NCT03838445

RECRUITING Phase 2 14 participants

129 Xenon Imaging in Patients Treated With Sotatercept

Bastiaan Driehuys

NCT06351345

ACTIVE NOT RECRUITING 1,195 participants

Pulmonary Vascular Disease Phenomics Program PVDOMICS

The Cleveland Clinic

NCT02980887

ACTIVE NOT RECRUITING Phase 3 935 participants

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Actelion

NCT04273945

ACTIVE NOT RECRUITING Phase 3 316 participants

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

GB002

NCT06274801

ACTIVE NOT RECRUITING 300 participants

ADAPT - A Patient Registry of the Real-world Use of Orenitram®

United Therapeutics

NCT03045029

ACTIVE NOT RECRUITING Phase 2 130 participants

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-031/LIGHTRAY EXTENSION)

Merck Sharp & Dohme

NCT06925750

ACTIVE NOT RECRUITING Phase 1 96 participants

A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension

Pfizer

NCT06137742

ACTIVE NOT RECRUITING Phase 2 91 participants

An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Arterial Hypertension (PAH)

Insmed Incorporated

NCT05649748

ACTIVE NOT RECRUITING Phase 2 74 participants

Open-label Extension Study of GB002 in Adult Subjects With Pulmonary Arterial Hypertension (PAH)

GB002, Inc., a wholly owned subsidiary of Gossamer Bio

NCT04816604

ACTIVE NOT RECRUITING NA 64 participants

DelIVery for Pulmonary Arterial Hypertension (PAH) & Continued Support Study

Medtronic Cardiac Rhythm and Heart Failure

NCT01321073

ACTIVE NOT RECRUITING NA 63 participants

Utility of At-home Monitoring of Exercise Capacity by App-based 6-minute Walk Test

Stanford University

NCT03893500

ACTIVE NOT RECRUITING Phase 2 63 participants

A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

Actelion

NCT03492177

ACTIVE NOT RECRUITING Phase 4 52 participants

A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension

United Therapeutics

NCT05203510

ACTIVE NOT RECRUITING NA 34 participants

Pulmonary Arterial Hypertension Improvement With Nutrition and Exercise (PHINE)

The Cleveland Clinic

NCT03288025

ACTIVE NOT RECRUITING Phase 4 30 participants

Sotatercept on Central Cardiopulmonary Performance and Peripheral Oxygen Transport During Exercise in Pulmonary Arterial Hypertension

Mayo Clinic

NCT06409026

ACTIVE NOT RECRUITING Phase 3 28 participants

A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD

Liquidia Technologies

NCT04691154

ACTIVE NOT RECRUITING NA 20 participants

Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension

University of Pennsylvania

NCT06543745

ACTIVE NOT RECRUITING 10 participants

Developing Hyperpolarized 129Xe MRI Biomarkers for Evaluation of Pulmonary Arterial Hypertension

University of Kansas Medical Center

NCT05339386

ACTIVE NOT RECRUITING 7 participants

The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI

Prisma Health-Upstate

NCT06907693

COMPLETED 1,333 participants

Study of Incidence of Respiratory Tract AEs in Patients Treated With Tyvaso® Compared to Other FDA Approved PAH Therapies

United Therapeutics

NCT01266265

COMPLETED 800 participants

A Registry for Patients Taking Uptravi

Actelion

NCT03278002

COMPLETED Phase 3 247 participants

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Actelion

NCT02558231

COMPLETED Phase 2 164 participants

A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) (MK-7962-024)

Merck Sharp & Dohme

NCT06664801

COMPLETED 156 participants

Novel Screening Strategies for Scleroderma PAH

University of Michigan

NCT01959815

COMPLETED Phase 4 108 participants

Effect of Selexipag on Daily Life Physical Activity of Patients With Pulmonary Arterial Hypertension.

Actelion

NCT03078907

COMPLETED Phase 4 105 participants

Assess the Efficacy and Safety of Sildenafil When Added to Bosentan in the Treatment of Pulmonary Arterial Hypertension

Pfizer's Upjohn has merged with Mylan to form Viatris

NCT00323297

COMPLETED NA 75 participants

Biomarkers in the Diagnosis and Assessment of Pulmonary Arterial Hypertension (PAH)

Northwell Health

NCT00566423

COMPLETED Phase 4 38 participants

Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1)

Gilead Sciences

NCT00617305

COMPLETED Phase 2 36 participants

Dose-response Study of the Safety and Efficacy of Beraprost Sodium Modified Release (BPS-MR) in Patients With Pulmonary Arterial Hypertension (PAH)

Lung Biotechnology PBC

NCT00989963

COMPLETED Phase 4 36 participants

EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension

United Therapeutics

NCT03497689

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Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 16
Phase 3 7
Phase 4 11

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Pulmonary Arterial Hypertension Trial Landscape

64 indexed Pulmonary Arterial Hypertension studies · 21 recruiting (33%).

Phase mix: 18 late (III/IV) vs 22 early (I/II).

Top sponsor: Actelion (7 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Pulmonary Arterial Hypertension?

PlainTrial tracks 64 US clinical trials for Pulmonary Arterial Hypertension, of which 21 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Pulmonary Arterial Hypertension?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.