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ClinicalTrials.gov 16 recruiting now official registry

Cutaneous Melanoma clinical trials

Every US clinical trial registered for Cutaneous Melanoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

31 US clinical trials · 16 currently recruiting

The research picture

Cutaneous Melanoma has 31 registered US clinical trials, 16 of them open to new participants right now — about 52% of the total.

16
recruiting participants now
52%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
2
top sponsor: H. Lee Moffitt Cancer Center and Research Institute

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 5,000 participants

Quality of Life, Lifestyle, and Psychosocial Factors in Patients With Melanoma

M.D. Anderson Cancer Center

NCT04778449

RECRUITING 2,020 participants

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Guardant Health

NCT05059444

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING Phase 1 365 participants

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

GV20 Therapeutics

NCT05669430

RECRUITING Phase 1 358 participants

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

GI Innovation

NCT05824975

RECRUITING Phase 1 336 participants

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

IDEAYA Biosciences

NCT03947385

RECRUITING 300 participants

Symptoms of Immune Checkpoint Inhibitor Therapy in Cutaneous Melanoma

University of California, San Francis

NCT07148245

RECRUITING Phase 1 240 participants

A Study Assessing KB707 for the Treatment of Locally Advanced or Metastatic Solid Tumors

Krystal Biotech

NCT05970497

RECRUITING Phase 1 168 participants

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

OncoResponse

NCT06090266

RECRUITING Phase 1 159 participants

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

Aulos Bioscience

NCT05267626

RECRUITING Phase 2 135 participants

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

Linnaeus Therapeutics

NCT06624644

RECRUITING Phase 2 100 participants

EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers

Ohio State University Comprehensive Cancer Center

NCT06223659

RECRUITING Phase 1 33 participants

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

University of Utah

NCT06194929

RECRUITING Phase 2 28 participants

Neoadjuvant Combination Immunotherapy for Stage III Melanoma

University of Louisville

NCT03842943

RECRUITING NA 20 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

AdventHealth Translational Research Institute

NCT06008977

RECRUITING Phase 1 15 participants

ACTengine® IMA203 Combined With mRNA-4203

Immatics US

NCT06946225

ACTIVE NOT RECRUITING Phase 2 340 participants

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Replimune

NCT03767348

ACTIVE NOT RECRUITING Phase 1 230 participants

A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Ascentage Pharma Group

NCT03611868

ACTIVE NOT RECRUITING Phase 1 126 participants

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Novartis Pharmaceuticals

NCT05544929

ACTIVE NOT RECRUITING NA 100 participants

MoleMapper, Visiomed, and Confocal Microscopy in Screening Participants for Melanoma

OHSU Knight Cancer Institute

NCT03699995

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 1 41 participants

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05571839

ACTIVE NOT RECRUITING Early Phase 1 22 participants

Exercise to Boost Response to Checkpoint Blockade Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05358938

ACTIVE NOT RECRUITING Phase 1 20 participants

Neoadjuvant Atezolizumab in Cutaneous Melanoma

The Methodist Hospital Research Institute

NCT04020809

ACTIVE NOT RECRUITING Phase 1 17 participants

Proof of Concept of TBio-4101, Lymphodepleting Chemo, IL-2 for Relapsed/Refractory Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT05628883

ACTIVE NOT RECRUITING Phase 1 11 participants

Neoantigen Vaccine Plus Locally Administered Ipilimumab and Systemic Nivolumab in Advanced Melanoma

Dana-Farber Cancer Institute

NCT03929029

ACTIVE NOT RECRUITING Phase 2 1 participants

Study of the Effectiveness and Safety of Acasunlimab Alone and With Pembrolizumab to Treat Advanced Melanoma of the Skin That Has Returned After Treatment With an Approved Checkpoint Inhibitor Therapy (ABBIL1TY MELANOMA-07)

Genmab

NCT06984328

COMPLETED Phase 1 164 participants

A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors

Eli Lilly and Company

NCT02791334

COMPLETED 38 participants

A Study To See Why Patients Agree To or Decline To Have Treatment After Surgery

Memorial Sloan Kettering Cancer Center

NCT03843593

COMPLETED Phase 2 36 participants

Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma

Ludwig Institute for Cancer Research

NCT00679289

COMPLETED Phase 1 20 participants

A Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positive Melanomas

Hoffmann-La Roche

NCT04551352

Phase Distribution

PhaseTrial count
Phase 1 18
Phase 2 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cutaneous Melanoma Trial Landscape

ClinicalTrials.gov lists 31 US studies indexed under Cutaneous Melanoma, and 16 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cutaneous Melanoma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cutaneous Melanoma is led by H. Lee Moffitt Cancer Center and Research Institute with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 31 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cutaneous Melanoma?

PlainTrial tracks 31 US clinical trials for Cutaneous Melanoma, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cutaneous Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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