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NCT06833320 · ClinicalTrials.gov registry record · Phase 1
Propranolol Treatment for Postoperative Chylothorax
A Phase 1 study of Congenital Heart Disease and Open Heart Surgery, sponsored by June Wu.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06833320: Recruiting Phase 1 study of Congenital Heart Disease and Open Heart Surgery, sponsored by June Wu.
NCT06833320 is a Phase 1 study of Congenital Heart Disease and Open Heart Surgery that is actively recruiting participants, run by June Wu. The registered enrollment target is 50 participants, below the 473-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06833320, a Phase 1 study of Congenital Heart Disease and Open Heart Surgery, is actively recruiting participants, sponsored by June Wu.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD). While it was thought to be mechanical injury to the thoracic duct, recent research demonstrated that there are intrinsically abnormal lung lymphatics in CHD patients, and after open heart surgery, the fluid shifts that occur overwhelms these abnormal lung lymphatics. As a result, postoperative chylothorax occurs. Propranolol has been found to be helpful in resolving postoperative chylothorax very quickly (9 days) in a subset of postoperative chylothorax patients (60%). However, it is not known why some patients respond and some do not. The investigators hypothesize that propranolol is safe to use in this patient population, and that certain clinical factors will predict propranolol response, but more importantly, some clinical factors can be optimize to allow more patients with postoperative chylothorax to respond to and benefit from propranolol. In order to improve the understanding of how propranolol works and to maximize benefit to patients, the investigators propose to perform a prospective, randomized, double-blind clinical trial to learn how to best use propranolol in patients with postoperative chylothorax.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Propranolol Hydrochloride
Study Locations (1)
New York
- Columbia University Irving Medical Center/NewYork-Presbyterian - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-09-09 |
| Est. Completion | 2031-01-01 |
| Phase | Phase 1 |
What NCT06833320 shows while recruiting
NCT06833320 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 473-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (89% lower).
The record links to 4 conditions, with Congenital Heart Disease appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06833320 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT06833320 about?
NCT06833320 is a clinical study titled "Propranolol Treatment for Postoperative Chylothorax". Postoperative chylothorax is a serious complication after open heart surgery for pediatric patients with congenital heart disease (CHD). While it was thought to be mechanical injury to the thoracic duct, recent research demonstrated that there are intrinsically abnormal lung lymphatics in CHD patien...
What is the current status of trial NCT06833320?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 50 participants. The study started on 2025-09-09. Estimated completion is 2031-01-01.
What conditions does trial NCT06833320 study?
This clinical trial studies the following conditions: Congenital Heart Disease, Open Heart Surgery, Postoperative Chylothorax, Chylothorax.
What interventions are being tested in trial NCT06833320?
The interventions under investigation include: Placebo (DRUG), Propranolol Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT06833320?
This trial is sponsored by June Wu, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06833320 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06833320's enrollment target sits among peer trials
50 41st of 63 higher than 18 of 63 other Congenital Heart Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Heart Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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