Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 33 recruiting now official registry

Congenital Heart Disease clinical trials

33 of 64 indexed Congenital Heart Disease trials are currently recruiting.

64 US clinical trials · 33 currently recruiting

Congenital Heart Disease is the subject of 64 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Boston Children's Hospital, running 9 of these trials.

The research picture

Congenital Heart Disease has 64 registered US clinical trials, 33 of them open to new participants right now, about 52% of the total.

33
recruiting participants now
52%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
9
top sponsor: Boston Children's Hospital
Phase 13Phase 21Phase 33

Active & Recent Trials

64 total, page 2 of 2

COMPLETED NA 65 participants

Improving Motor Skill Development in Infants After Cardiac Surgery

University of Michigan

NCT02700646

COMPLETED 64 participants

Splanchnic and Renal Tissue Oxygenation During Enteral Feedings in Neonates With Patent Ductus Arteriosus

University of Utah

NCT03551600

COMPLETED Phase 3 63 participants

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

University of California, Los Angeles

NCT05049590

COMPLETED 53 participants

Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children

University of Colorado, Denver

NCT02728128

COMPLETED NA 51 participants

Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements

University of California, Davis

NCT05637814

COMPLETED 40 participants

Does Modified Ultrafiltration Affect Thromboelastography Results?

Wake Forest University Health Sciences

NCT03214120

COMPLETED 40 participants

Determination of the Minimal Concentration of Antifibrinolytics Required to Inhibit t-PA-activated Fibrinolysis

Boston Children's Hospital

NCT02352675

COMPLETED NA 30 participants

Acetaminophen for Oxidative Stress After Cardiopulmonary Bypass

Vanderbilt University Medical Center

NCT01228305

COMPLETED 28 participants

Neurodevelopmental Outcomes in Hypoplastic Left Heart Syndrome

Emory University

NCT00399555

COMPLETED NA 25 participants

MyHeartBaby: An Initial Evaluation of the MyHeartBaby Psychosocial Telemedicine Program

Emory University

NCT02895334

COMPLETED NA 23 participants

Enhanced External Counterpulsation in Patients With Fontan Circulation

Boston Children's Hospital

NCT04956952

COMPLETED NA 21 participants

Angiotensin Converting Enzyme Inhibitors During Cardiopulmonary Bypass in Infants and Children

Vanderbilt University Medical Center

NCT00848250

COMPLETED NA 12 participants

Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle Training

Boston Children's Hospital

NCT01977222

COMPLETED Phase 1 10 participants

Phase I Safety and Feasibility Study of Intracoronary Delivery of Autologous Bone Marrow Derived Mononuclear Cells

Timothy J Nelson, MD, PhD

NCT02549625

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 1
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Congenital Heart Disease Trial Landscape

64 indexed Congenital Heart Disease studies · 33 recruiting (52%).

Phase mix: 3 late (III/IV) vs 4 early (I/II).

Top sponsor: Boston Children's Hospital (9 trials), 9 others listed. 14 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Congenital Heart Disease?

PlainTrial tracks 64 US clinical trials for Congenital Heart Disease, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Congenital Heart Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.