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NCT04299828 · ClinicalTrials.gov registry record
Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
A clinical trial of Congenital Heart Disease and Coagulation, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT04299828: Recruiting study of Congenital Heart Disease and Coagulation, sponsored by Boston Children's Hospital.
NCT04299828 is a study of Congenital Heart Disease and Coagulation that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 100 participants, below the 472-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04299828, a study of Congenital Heart Disease and Coagulation, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.
Primary Outcome
characterization of monocyte activation status at baseline before surgery and throughout the course of CPB including post-operatively.
Conditions Studied
Interventions
- OTHER Discarded blood samples
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2022-05-31 |
| Est. Completion | 2026-12 |
What NCT04299828 shows while recruiting
NCT04299828 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 472-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (79% lower).
The record links to 2 conditions, with Congenital Heart Disease appearing as the primary indexed condition, and to 1 intervention - of which Discarded blood samples is the first listed.
NCT04299828 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04299828 about?
NCT04299828 is a clinical study titled "Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery". The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to: 1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and s...
What is the current status of trial NCT04299828?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2022-05-31. Estimated completion is 2026-12.
What conditions does trial NCT04299828 study?
This clinical trial studies the following conditions: Congenital Heart Disease, Coagulation.
What interventions are being tested in trial NCT04299828?
The interventions under investigation include: Discarded blood samples (OTHER).
Who is sponsoring clinical trial NCT04299828?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04299828 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congenital Heart Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04299828's enrollment target sits among peer trials
100 29th of 63 higher than 33 of 63 other Congenital Heart Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Heart Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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