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NCT00243776 · ClinicalTrials.gov registry record

Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

A clinical trial of Congenital Heart Disease and Tetralogy of Fallot, sponsored by Emory University.

Recruiting
Registry status
600
Enrollment target
1
Study location

NCT00243776: Recruiting study of Congenital Heart Disease and Tetralogy of Fallot, sponsored by Emory University.

NCT00243776 is a study of Congenital Heart Disease and Tetralogy of Fallot that is actively recruiting participants, run by Emory University. The registered enrollment target is 600 participants, above the 464-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (29% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00243776, a study of Congenital Heart Disease and Tetralogy of Fallot, is actively recruiting participants, sponsored by Emory University.

RECRUITING
Registry status
600 participants
Enrollment target
1
Study location

Study Summary

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigators hypothesize that infant hearts have different regulation of calcium entry than adult hearts. The study team also wants to study combinations of 3D cardiac spheres with multiple environmental cues that can improve functional and metabolic maturation of Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) and generate a more clinically relevant cell model.

Primary Outcome

Calcium currents including transients and modulation of calcium handling by activation of different pathways in isolated cells from waste tissue obtained at the time of surgical repair for Congenital Heart Disease will be measured for the duration of the study.

Conditions Studied

Congenital Heart Disease Tetralogy of Fallot

Study Locations (1)

Georgia

  • Emory University School of Medicine - Atlanta

Trial Details

FieldValue
Enrollment Target 600 participants
Start Date 2005-04
Est. Completion 2025-12-31
Emory University

1,208 total trials

What NCT00243776 shows while recruiting

NCT00243776 is an observational study that tracks outcomes without assigning an intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap, above the 464-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (29% higher).

The record links to 2 conditions, with Congenital Heart Disease appearing as the primary indexed condition, and to 0 interventions.

NCT00243776 reports a single indexed study location in Georgia.

Frequently Asked Questions

What is clinical trial NCT00243776 about?

NCT00243776 is a clinical study titled "Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development". The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the he...

What is the current status of trial NCT00243776?

This trial is currently recruiting. The enrollment target is 600 participants. The study started on 2005-04. Estimated completion is 2025-12-31.

What conditions does trial NCT00243776 study?

This clinical trial studies the following conditions: Congenital Heart Disease, Tetralogy of Fallot.

Who is sponsoring clinical trial NCT00243776?

This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00243776 being conducted?

This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Congenital Heart Disease

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00243776's enrollment target sits among peer trials

600 7th of 63 higher than 57 of 63 other Congenital Heart Disease trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Congenital Heart Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT00243776

Source: ClinicalTrials.gov NCT00243776, the US trial registry maintained by the National Library of Medicine. NCT00243776 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.