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NCT01192048 · ClinicalTrials.gov registry record
Genetics of Congenital Heart Disease
A clinical trial of Congenital Heart Disease, sponsored by Nationwide Children's Hospital.
- Recruiting
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT01192048: Recruiting study of Congenital Heart Disease, sponsored by Nationwide Children's Hospital.
NCT01192048 is a study of Congenital Heart Disease that is actively recruiting participants, run by Nationwide Children's Hospital. The registered enrollment target is 1,000 participants, above the 458-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (118% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01192048, a study of Congenital Heart Disease, is actively recruiting participants, sponsored by Nationwide Children's Hospital.
- RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown. Numerous epidemiologic studies have demonstrated evidence that genetic factors likely play a contributory, if not causative, role in CHD. While numerous genes have been identified by us and other investigators using traditional genetic approaches, these genes account for a minority of the non-syndromic CHDs. Therefore, we are now utilizing whole genome sequencing (WGS), with the addition of more traditional genetic techniques such as chromosomal microarray or traditional linkage analysis, to identify genetic causes of familial and isolated CHD. With WGS we are able to sequence all of the genetic material of an individual and apply different data analysis techniques based on whether we are analyzing a multiplex family or a cohort of trios (mother, father and child with CHD) with a specific isolated CHD. Therefore, WGS is a robust method for identification of novel genetic causes of CHD which will have important diagnostic and therapeutic consequences for these children.
Primary Outcome
Novel genetic abnormalities that are found to be associated with congenital heart defects in humans
Conditions Studied
Interventions
- OTHER Blood Sample Collection
Study Locations (1)
Ohio
- Nationwide Children's Hospital - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2009-12 |
| Est. Completion | 2025-12 |
What NCT01192048 shows while recruiting
NCT01192048 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, above the 458-participant average among 63 other Congenital Heart Disease trials with a reported enrollment target (118% higher).
The record links to 1 condition, with Congenital Heart Disease appearing as the primary indexed condition, and to 1 intervention - of which Blood Sample Collection is the first listed.
NCT01192048 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT01192048 about?
NCT01192048 is a clinical study titled "Genetics of Congenital Heart Disease". Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown. Numerous epidemiologic studies have demonstrated evidence that genetic factors likely play a contributory, if not causative, role in CHD. While numerous gen...
What is the current status of trial NCT01192048?
This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2009-12. Estimated completion is 2025-12.
What conditions does trial NCT01192048 study?
This clinical trial studies the following conditions: Congenital Heart Disease.
What interventions are being tested in trial NCT01192048?
The interventions under investigation include: Blood Sample Collection (OTHER).
Who is sponsoring clinical trial NCT01192048?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01192048 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congenital Heart Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01192048's enrollment target sits among peer trials
1,000 4th of 63 higher than 58 of 63 other Congenital Heart Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Heart Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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