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ClinicalTrials.gov 134 recruiting now official registry

Cardiovascular Diseases clinical trials

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

304 US clinical trials · 134 currently recruiting

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

The research picture

Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.

134
recruiting participants now
44%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
10
top sponsor: Duke University
Phase 110Phase 218Phase 313Phase 413

Active & Recent Trials

304 total, page 2 of 7

RECRUITING NA 400 participants

SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation

The Miriam Hospital

NCT06886789

RECRUITING 400 participants

Structural Conditions and Health After Release From Prison

Kaiser Permanente

NCT05989282

RECRUITING 400 participants

Biopsy Collection and Repository Database

Kenneth S. Campbell

NCT05521503

RECRUITING 350 participants

TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

Brigham and Women's Hospital

NCT00985049

RECRUITING NA 340 participants

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

Ohio State University

NCT06055036

RECRUITING NA 340 participants

The PulsePoint Study

Dr. Steven Brooks

NCT04806958

RECRUITING NA 300 participants

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR

Cardiac Dimensions

NCT03142152

RECRUITING 300 participants

Gut Microbiota in Metabolic Surgery

Vanderbilt University Medical Center

NCT05000996

RECRUITING 300 participants

BLOOM: Biological Legacy of Origin in Mother-Infant Dyads

University of Miami

NCT02000895

RECRUITING NA 260 participants

Text Education About Cardiovascular Health and HIV (TEACH-HIV)

University of California, San Francisco

NCT05642858

RECRUITING NA 260 participants

Patient Care Outreach, Navigation, Technology and Support 2.0

University of California, San Francisco

NCT06648278

RECRUITING NA 250 participants

Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

VA Office of Research and Development

NCT06244199

RECRUITING Phase 2 250 participants

Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT

Vanderbilt University Medical Center

NCT05288790

RECRUITING NA 200 participants

Effects of Whole vs. Nonfat Milk Consumption on Body Composition in Children

Boston Children's Hospital

NCT05464186

RECRUITING Phase 2 200 participants

NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals

University of Alabama at Birmingham

NCT04055428

RECRUITING NA 200 participants

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

University of Alabama at Birmingham

NCT05216042

RECRUITING NA 200 participants

Wellness Intervention for Smoking and HIV

University of Arizona

NCT04725617

RECRUITING NA 200 participants

Cardiovascular Risk Reduction for Adults With Food Insecurity Using Structured Incentives

State University of New York at Buffalo

NCT06818669

RECRUITING NA 200 participants

Techquity by FAITH!

Mayo Clinic

NCT06187077

RECRUITING Phase 2 200 participants

Omega-3D: Omega-3 for Diet-Driven Health Disparities

University of Arizona

NCT07078344

RECRUITING 189 participants

PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

Aventusoft

NCT06567795

RECRUITING NA 180 participants

CV CARE: CardioVascular Care in PC Patients

Dana-Farber Cancer Institute

NCT06202820

RECRUITING NA 177 participants

Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs

C5 Biomedical

NCT06674980

RECRUITING NA 175 participants

SPYRAL GEMINI Pilot Study

Medtronic Vascular

NCT06907147

RECRUITING NA 167 participants

Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder

University of California, Los Angeles

NCT05516277

RECRUITING Phase 2 160 participants

PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis

University of Alabama at Birmingham

NCT04971720

RECRUITING NA 150 participants

Groceries for Residents of Southeastern USA to Stop Hypertension

Beth Israel Deaconess Medical Center

NCT06891911

RECRUITING 150 participants

CV Imaging of Metabolic Interventions

The Cleveland Clinic

NCT05650307

RECRUITING Phase 2 150 participants

Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation Among Veterans

VA Office of Research and Development

NCT05423158

RECRUITING Phase 3 132 participants

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

VA Office of Research and Development

NCT04877197

RECRUITING Phase 2 130 participants

Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial

Wake Forest University Health Sciences

NCT06488105

RECRUITING NA 125 participants

NightWare and Cardiovascular Health in Veterans With PTSD

VA Office of Research and Development

NCT06419959

RECRUITING NA 125 participants

CLEANer Aspiration for Pulmonary Embolism

Argon Medical Devices

NCT06189313

RECRUITING Phase 2 121 participants

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

Priscilla Hsue, MD

NCT05488431

RECRUITING 120 participants

VicorderCS NIBP Validation Study to Review The Ability to Capture Blood Pressure Measurements

80 Beats Medical

NCT06560034

RECRUITING NA 120 participants

Exercise Activity Intervention With Sensor-Based Engagement in Patients With Atrial Fibrillation

Icahn School of Medicine at Mount Sinai

NCT06938412

RECRUITING 100 participants

EVOC - EVs in Obesity and Cardiometabolic Disease

Massachusetts General Hospital

NCT06408961

RECRUITING NA 100 participants

Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics

Washington University School of Medicine

NCT06397729

RECRUITING NA 100 participants

Home-Based Cardiac Rehabilitation for Patients With Heart Failure

Vanderbilt University Medical Center

NCT06479876

RECRUITING Phase 4 100 participants

Secondhand Tobacco Smoke and Cardiovascular Disease

University of California, San Francisco

NCT04715568

RECRUITING NA 96 participants

The Cooking for Health Optimization and Disease Prevention (CHOP) Trial

Tulane University

NCT07011459

RECRUITING NA 95 participants

Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population

Boston University Charles River Campus

NCT04895995

RECRUITING NA 90 participants

Inspire HER: Inspiring the Heart and Emotions for Radical Health

University of Alabama at Birmingham

NCT06966258

RECRUITING Phase 1 81 participants

A Study to Evaluate the Safety, PK/PD of (OriCAR-017) in Subjects With RR/MM - RIGEL Study

OriCell Therapeutics Co.

NCT06271252

RECRUITING Early Phase 1 80 participants

Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure

University of Minnesota

NCT06507657

RECRUITING 80 participants

Black Women's Life Experience On Cardiovascular Health Via Ongoing Monitoring

The University of Texas at Arlington

NCT06150989

RECRUITING NA 80 participants

Feasibility of Reducing Cardiovascular Disease Risk Factors in Hispanics Through a Family-Based Community Intervention

Poudre Valley Health System

NCT05322876

RECRUITING NA 76 participants

Brain Connections for Arm Movement After Stroke

VA Office of Research and Development

NCT04286516

RECRUITING Phase 3 65 participants

Cardiovascular Effects of a Healthy Dietary Pattern Containing Eggs

Penn State University

NCT06120400

RECRUITING Phase 1 64 participants

Prevention of Progression of Prediabetes, Obesity and CV Risk

The University of Texas Health Science Center at San Antonio

NCT06446531

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Diseases Trial Landscape

304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).

Phase mix: 26 late (III/IV) vs 28 early (I/II).

Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Diseases?

PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.