Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Suicide

Open-data reference.

93 US clinical trials · 41 currently recruiting

Active & Recent Trials

RECRUITING NA 12,838 participants

e-Connect: A Service System Intervention for Justice Youth at Risk for Suicide

Columbia University

NCT03586895

RECRUITING NA 4,000 participants

Reaching Out to Distressed Medical Residents, Fellows and Faculty

Oregon Health and Science University

NCT02010866

RECRUITING NA 4,000 participants

Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

Massachusetts General Hospital

NCT05671133

RECRUITING Phase 2 1,600 participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

University of California, Los Angeles

NCT05304065

RECRUITING NA 1,485 participants

Preventing Suicide Among Sexual and Gender Diverse Young Adults in Primary Care

Elizabeth Arnold

NCT05869552

RECRUITING NA 1,000 participants

Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings

Johns Hopkins University

NCT06151158

RECRUITING 500 participants

Natural History of Depression, Bipolar Disorder and Suicide Risk

National Institute of Mental Health (NIMH)

NCT06462196

RECRUITING Phase 2 472 participants

Computerized Cognitive Behavioral Therapies for Suicide Prevention and Depression

VA Eastern Colorado Health Care System

NCT06375083

RECRUITING NA 468 participants

Mental Health in Primary Care

University of Miami

NCT05426057

RECRUITING NA 420 participants

Text-based Support for Parents of Adolescents Following an Emergency Department Visits

University of Michigan

NCT06660199

RECRUITING NA 300 participants

Piloting a Culturally Adapted Suicide Prevention for Black Students in Chicago

University of Chicago

NCT07125144

RECRUITING NA 240 participants

Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents

University of Alabama at Birmingham

NCT05437588

RECRUITING NA 213 participants

Intensive Crisis Intervention

Jennifer Hughes

NCT06476886

RECRUITING NA 200 participants

Real-time Examination of Skills and Coping Use in Teen's Everyday Lives

University of Utah

NCT06720753

RECRUITING NA 185 participants

Just-in-time Interventions for Reducing Short-term Suicide Risk

Massachusetts General Hospital

NCT05793541

RECRUITING NA 180 participants

Caring Connections Youth Suicide Detection and Intervention Study

University of North Carolina, Chapel Hill

NCT06353711

RECRUITING NA 170 participants

Suicide Prevention for Sexual and Gender Minority Youth (Randomized Controlled Trial)

San Diego State University

NCT05669976

RECRUITING NA 169 participants

Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

University of Pittsburgh

NCT06191484

RECRUITING 144 participants

Proximal Risk for Suicide in Adolescents

Oregon Health and Science University

NCT06400810

RECRUITING Phase 2 136 participants

Suicide Risk Interventions

VA Office of Research and Development

NCT05931289

RECRUITING NA 100 participants

Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD

Texas Tech University

NCT06055322

RECRUITING Phase 3 100 participants

Study About Group and Phone Follow-Up After a Crisis

University of Rochester

NCT05637203

RECRUITING NA 90 participants

Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

University of Pittsburgh

NCT06963463

RECRUITING NA 80 participants

Functional Connectivity Alterations in Suicidal Patients Among Opioid Users

Baylor College of Medicine

NCT05489042

RECRUITING NA 80 participants

Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

Massachusetts General Hospital

NCT04130958

RECRUITING NA 78 participants

A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide

Ksana Health

NCT05920252

RECRUITING NA 68 participants

Targeting Emotion Dysregulation to Reduce Suicide in People With Psychosis

University of Maryland, Baltimore

NCT05440214

RECRUITING NA 60 participants

Youth Empowerment and Safety Intervention

Case Western Reserve University

NCT07214233

RECRUITING NA 60 participants

Brief Cognitive Behavioral Therapy for People With Physical Disabilities

Ohio State University

NCT05695430

RECRUITING Phase 1 57 participants

Army-SPRING Army-Suicide Prevention Research

University of Pennsylvania

NCT06547008

RECRUITING NA 57 participants

Development of a Recovery Oriented Treatment for Post-Acute Suicidal Episode (PASE) Veterans

VA Office of Research and Development

NCT04731519

RECRUITING NA 50 participants

Randomized Clinical Trial of Supplementing Brief Psychotherapy With a Mobile App

Rutgers, The State University of New Jersey

NCT06555094

RECRUITING NA 50 participants

The Use of Voice-Based AI in 988 Crisis Counseling

Lyssn.io

NCT06299384

RECRUITING Phase 1 50 participants

Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department

Lindsay Maguire, MD

NCT06085937

RECRUITING Phase 2 50 participants

Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

National Institute of Mental Health (NIMH)

NCT06511908

RECRUITING NA 50 participants

Mobile Intervention for Suicidal Thoughts

VA Office of Research and Development

NCT06593379

RECRUITING NA 30 participants

NIMH Clinical Pathway in Rural Appalachian School-based Health Clinics

West Virginia University

NCT06808503

RECRUITING NA 26 participants

Co-Designing a Virtual Reality Intervention to Enhance Skill Development

University of North Carolina, Chapel Hill

NCT07186543

RECRUITING Phase 2 24 participants

Ketamine & Crisis Response Plan for Suicidal Ideation in the ED

The University of Texas Health Science Center at San Antonio

NCT05696691

RECRUITING NA 15 participants

Suicide Specific Rumination in Veterans

VA Office of Research and Development

NCT06481033

RECRUITING NA 10 participants

Feasibility, Acceptability, and Preliminary Efficacy of a Novel Personalized Mobile Intervention for Suicide - Open Trial (2)

Butler Hospital

NCT05180344

ACTIVE NOT RECRUITING NA 52,323 participants

The Community Youth Development Study: A Test of Communities That Care

University of Washington

NCT01088542

ACTIVE NOT RECRUITING NA 3,629 participants

Scaling up e-Connect in Juvenile Probation Settings

New York State Psychiatric Institute

NCT05541926

ACTIVE NOT RECRUITING NA 1,491 participants

Promoting Community Conversations About Research to End Native Youth Suicide in Rural Alaska

University of Michigan

NCT03661255

ACTIVE NOT RECRUITING NA 854 participants

Comparing Suicide Prevention Interventions to Guide Follow-up Care: The SPRING Trial

St. Luke's Health System, Boise, Idaho

NCT06128239

ACTIVE NOT RECRUITING NA 850 participants

Veterans Coordinated Community Care (3C) Study

Brown University

NCT05272176

ACTIVE NOT RECRUITING NA 512 participants

Preventing Suicide in African American Adolescents

DePaul University

NCT04253002

ACTIVE NOT RECRUITING NA 300 participants

Adaptive Intervention for Adolescents Following Inpatient Psychiatric Care

University of Michigan

NCT05282225

ACTIVE NOT RECRUITING 250 participants

Wearable Suicidal Early Warning System for Adolescents

Oregon Health and Science University

NCT03030924

ACTIVE NOT RECRUITING NA 191 participants

Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy

Ohio State University

NCT05275101

ACTIVE NOT RECRUITING NA 104 participants

Treatment for Relationships and Safety Together

VA Office of Research and Development

NCT04816149

ACTIVE NOT RECRUITING NA 86 participants

Family Safety Net - Aim 3: Randomized Control Trial

University of Michigan

NCT05657119

ACTIVE NOT RECRUITING NA 70 participants

Youth Nominated Support Team

University of California, Irvine

NCT05558332

ACTIVE NOT RECRUITING NA 20 participants

Optimizing a Just-in-time Adaptive Intervention for Suicide Safety Planning in Adolescents

Ksana Health

NCT06665620

COMPLETED NA 493,756 participants

A System of Safety (SOS)

University of Massachusetts, Worcester

NCT03104504

COMPLETED Phase 2 50,000 participants

Evaluation of a School-Based Training Program for Suicide Prevention

University of Rochester

NCT00118443

COMPLETED NA 2,055 participants

Peer to Peer Programs for Military Suicide Prevention

University of Utah

NCT04021758

COMPLETED NA 1,000 participants

Systems Aligning for Equity (SAFE) Spaces

New York University

NCT05658068

COMPLETED NA 939 participants

Social Ecology and the Prevention of Suicide and Aggression in African American Youth

DePaul University

NCT03954457

COMPLETED NA 906 participants

Preventing Addiction Related Suicide (PARS)

University of Washington

NCT03166709

COMPLETED NA 800 participants

Suicide Prevention Intervention for At-Risk Individuals in Transition

Michigan State University

NCT02759172

COMPLETED NA 488 participants

Facilitating Use of the National Suicide Prevention Lifeline in Alcohol Patients (Reach Out)

University of Michigan

NCT04488055

COMPLETED NA 266 participants

Improving Firearm Storage in Alaska Native Villages

University of Washington

NCT00643812

COMPLETED NA 233 participants

Building Stronger Allies

Florida State University

NCT03571750

COMPLETED NA 200 participants

Now Matters Now: An Online Suicide Prevention Program

Kaiser Permanente

NCT01924936

COMPLETED NA 143 participants

Family-based Crisis Intervention With Suicidal Adolescents in the ED

Boston Children's Hospital

NCT02610309

COMPLETED NA 135 participants

Mindfulness-Based Cognitive Therapy for Suicide Prevention

VA Office of Research and Development

NCT01872338

COMPLETED NA 124 participants

Wakȟáŋyeža (Little Holy One)

Johns Hopkins University

NCT04201184

COMPLETED NA 120 participants

TMS for Suicidal Crisis in Active Duty SMs

Eisenhower Army Medical Center

NCT03014362

COMPLETED NA 115 participants

Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0

HealthPartners Institute

NCT04939727

COMPLETED NA 103 participants

Promoting Safety Plan and Coping Strategy Use Among Adults With Suicidal Thoughts

Massachusetts General Hospital

NCT05791643

COMPLETED NA 102 participants

A Brief Intervention to Reduce Suicide Risk in Military Service Members and Veterans - Study 2 (SAFEMIL)

Henry M. Jackson Foundation for the Advancement of Military Medicine

NCT01360736

COMPLETED Phase 2 99 participants

Treatment of Suicidal Women With Borderline Personality Disorder

University of Washington

NCT00183651

COMPLETED 80 participants

Biomarkers as Predictors of Suicidal Risk in Adolescents

The Cleveland Clinic

NCT03014518

COMPLETED NA 74 participants

Computerized Anxiety Treatment for Suicide

Florida State University

NCT01990131

COMPLETED Phase 1 72 participants

Effectiveness of a Family-Based Intervention for Adolescent Suicide Attempters (The SAFETY Study)

University of California, Los Angeles

NCT00692302

COMPLETED Phase 3 66 participants

Preventing Youth Suicide in Primary Care: A Family Model

Children's Hospital of Philadelphia

NCT00604097

COMPLETED NA 65 participants

Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms

Yale University

NCT05317481

COMPLETED NA 64 participants

Suicide Prevention Intervention for Vulnerable Emerging Adult Sexual Minorities

University of Pennsylvania

NCT05018143

COMPLETED Phase 2 61 participants

Developing an Intervention to Promote Lethal Means Safety in Suicidal Adolescents

University of Texas Southwestern Medical Center

NCT05423483

COMPLETED NA 60 participants

Suicide Prevention for Patients With Chronic Pain

Veterans BioMedical Research Institute

NCT04490265

COMPLETED NA 54 participants

Practice Experiences for School Reintegration

University of North Carolina, Chapel Hill

NCT05934396

COMPLETED NA 49 participants

Assisting in Decisions in Emergency Departments: (ED-AID) Study

University of Colorado, Denver

NCT03478501

COMPLETED NA 46 participants

Latino/a Adolescents With Suicidal Behavior

Brown University

NCT02820636

COMPLETED NA 40 participants

Pilot RCT of a Video-based Intervention for Suicide Prevention

Butler Hospital

NCT05127330

COMPLETED NA 31 participants

Suicide Prevention for Sexual and Gender Minority Youth (Open Trial)

San Diego State University

NCT05087966

COMPLETED NA 27 participants

Pilot of Training on 988 and Narcan

RAND

NCT07072819

COMPLETED NA 26 participants

CAMS-RAS: for Suicide Prevention

Evidence-Based Practice Institute, Seattle, WA

NCT03072875

COMPLETED NA 24 participants

Concurrent Treatment for Depressed Parents and DepressedAdolescents

Brown University

NCT00951821

COMPLETED NA 21 participants

Efficacy of a Brief Nightmare Treatment for Veterans

University of Tul

NCT01220401

COMPLETED NA 14 participants

Effects of Neuromodulation and Cognitive Training for Suicide in Veterans (ENACTS)

VA Office of Research and Development

NCT05231213

COMPLETED Phase 2 12 participants

Ketamine for Depression and Suicide Risk

Mayo Clinic

NCT02094898

COMPLETED NA 10 participants

Feasibility, Acceptability, and Preliminary Efficacy of a Novel Personalized Mobile Intervention for Suicide - Open Trial

Butler Hospital

NCT05180331

Phase Distribution

PhaseTrial count
Early Phase 1 3
Phase 2 9
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Suicide Trial Landscape

ClinicalTrials.gov lists 93 US studies indexed under Suicide, and 41 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Suicide shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 12 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Suicide is led by VA Office of Research and Development with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 93 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Suicide?

PlainTrial tracks 93 US clinical trials for Suicide, of which 41 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Suicide?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →