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NCT04715568 · ClinicalTrials.gov registry record · Phase 4
Secondhand Tobacco Smoke and Cardiovascular Disease
A Phase 4 study of Hypertension and Cardiovascular Diseases, sponsored by University of California, San Francisco.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT04715568: Recruiting Phase 4 study of Hypertension and Cardiovascular Diseases, sponsored by University of California, San Francisco.
NCT04715568 is a Phase 4 study of Hypertension and Cardiovascular Diseases that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 100 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04715568, a Phase 4 study of Hypertension and Cardiovascular Diseases, is actively recruiting participants, sponsored by University of California, San Francisco.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secondhand tobacco smoke.
Primary Outcome
LVEF will be measured using Magnetic Resonance Imaging (MRI) using General Electric 1.5 Tesla MRI system without gadolinium contrast. In accordance with the American College of Cardiology (ACC), results will be reported quantitatively and qualitatively as follows: Hyperdynamic = LVEF greater than 70%, Normal = LVEF 50% to 70% (midpoint 60%), Mild dysfunction = LVEF 40% to 49% (midpoint 45%), Moderate dysfunction = LVEF 30% to 39% (midpoint 35%), Severe dysfunction = LVEF less than 30%.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Losartan
Study Locations (1)
California
- San Francisco Veterans' Affairs Medical Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-03-30 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 4 |
What NCT04715568 shows while recruiting
NCT04715568 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04715568 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04715568 about?
NCT04715568 is a clinical study titled "Secondhand Tobacco Smoke and Cardiovascular Disease". This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to second...
What is the current status of trial NCT04715568?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 100 participants. The study started on 2021-03-30. Estimated completion is 2026-12-31.
What conditions does trial NCT04715568 study?
This clinical trial studies the following conditions: Hypertension, Cardiovascular Diseases.
What interventions are being tested in trial NCT04715568?
The interventions under investigation include: Placebo (DRUG), Losartan (DRUG).
Who is sponsoring clinical trial NCT04715568?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04715568 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04715568's enrollment target sits among peer trials
100 292nd of 470 higher than 170 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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