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NCT06408961 · ClinicalTrials.gov registry record
EVOC - EVs in Obesity and Cardiometabolic Disease
A clinical trial of Cardiovascular Diseases, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 100
- Enrollment target
- 1
- Study location
NCT06408961: Recruiting study of Cardiovascular Diseases, sponsored by Massachusetts General Hospital.
NCT06408961 is a study of Cardiovascular Diseases that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 100 participants, below the 26,974-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06408961, a study of Cardiovascular Diseases, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, the focus is on the content and function of Extracellular Vesicles (EVs), small sacs released from a cell's surface that contain important molecular cargo. The main questions it aims to answer are: 1. What molecular cargo do adipose-tissue EVs carry? 2. How do these cargo impact cardiac and hepatic function? 3. Are changes in EV content related to cardiac function and adiposity with weight loss? Tissue samples from fat tissue and blood samples will be collected from patients receiving bariatric weight loss surgery.
Primary Outcome
The study staff aim to obtain EVs from fat samples obtained at the time of bariatric weight loss surgery. The activity of genes within the cargo of the collected EVs are assessed using RNA sequencing and protein contents analysis. A statistical analysis performed utilizing computer technology will provide us with differentially expressed cargo that may be a step in the molecular communication pathway to the heart and liver tissues.
Conditions Studied
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2019-02-02 |
| Est. Completion | 2026-05-30 |
What NCT06408961 shows while recruiting
NCT06408961 is an observational study that tracks outcomes without assigning an intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 26,974-participant average among 300 other Cardiovascular Diseases trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Cardiovascular Diseases appearing as the primary indexed condition, and to 0 interventions.
NCT06408961 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06408961 about?
NCT06408961 is a clinical study titled "EVOC - EVs in Obesity and Cardiometabolic Disease". The goal of this observational study is to research the impact of molecular signals from the heart, liver and fat tissue on cardiovascular disease risk, and the presentation of Type II Diabetes and diseases that affect the heart, blood vessels and metabolism (Cardiometabolic Disease). Specifically, ...
What is the current status of trial NCT06408961?
This trial is currently recruiting. The enrollment target is 100 participants. The study started on 2019-02-02. Estimated completion is 2026-05-30.
What conditions does trial NCT06408961 study?
This clinical trial studies the following conditions: Cardiovascular Diseases.
Who is sponsoring clinical trial NCT06408961?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06408961 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cardiovascular Diseases
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06408961's enrollment target sits among peer trials
100 194th of 300 higher than 101 of 300 other Cardiovascular Diseases trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cardiovascular Diseases trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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