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Cardiovascular Diseases clinical trials
134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.
304 US clinical trials · 134 currently recruiting
Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.
The research picture
Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.
- 134
- recruiting participants now
- 44%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 10
- top sponsor: Duke University
Active & Recent Trials
304 total, page 3 of 7
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Kalie Tommerdahl
NCT05065372
Role of Endothelial Function in SCI CVD Risk
Craig Hospital
NCT06443151
Treatment With Aspirin After Preeclampsia: TAP Trial
Malamo Countouris
NCT06281665
Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics
Washington University School of Medicine
NCT06063564
Role of Adiposomes in Endothelial Dysfunction
University of Illinois at Chicago
NCT05199454
Designing and Assessing a Women Only Cardiac Rehabilitation (CARE) Program
University of Michigan
NCT06784895
HIIT Effects on Cardiometabolic Health
Syracuse University
NCT05838950
The Weight of Cardiovascular Disease
Mayo Clinic
NCT06053645
ADAPT Micro-Randomized Trial
University of Michigan
NCT06915220
The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health
Penn State University
NCT06216678
Personalized GI Motility Responses to Diet
University of Illinois at Urbana-Champaign
NCT06386471
Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease
Northwestern University
NCT05082402
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
Massachusetts General Hospital
NCT06001814
Identifying Strategies to Reduce Cardiovascular Risk Among Mothers of Young Children
NYU Langone Health
NCT06796075
Ketogenic Diet in Healthy Adults With Differing BMI
Penn State University
NCT06515912
PKP2-ACM Natural History Study
Rocket Pharmaceuticals
NCT06644742
Sleep and Circadian Mechanisms in Hypertension
Oregon Health and Science University
NCT05184933
Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy
University of Utah
NCT05826925
NSAIDs vs. Coxibs in the Presence of Aspirin
Inova Health Care Services
NCT03699293
A Pilot Feasibility and Acceptability Study of Remote ExerciSe Training mOdalities (PRESTO)
NYU Langone Health
NCT06931470
Remote Vinyasa Yoga Program for Heart Health
West Virginia University
NCT06961981
WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
Arizona State University
NCT06963736
Role of Aging and Individual Variation in Exercise Training Responsiveness
Duke University
NCT06471569
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
Nationwide Children's Hospital
NCT04467671
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
University of Kansas Medical Center
NCT04715022
A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD
Pulmovant
NCT07333183
Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )
Wake Forest University
NCT06375694
The TRICURE EFS Study
TRiCares
NCT06506942
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
Kessler Foundation
NCT05731986
Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke
Jorge Gonzalez-Martinez
NCT06303869
The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health
University of California, Davis
NCT06476795
The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)
Kessler Foundation
NCT05725499
Chardonnay Marc and Vascular Response
University of California, Davis
NCT05545865
Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement
Kaiser Permanente
NCT06571747
Bogalusa Heart Study
Tulane University
NCT00005129
University of North Carolina Alumni Heart Study
Duke University
NCT00005398
Cardiovascular Health Study (CHS)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005133
The Jackson Heart Study of Cardiovascular Disease Among African Americans
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005485
A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
Eli Lilly and Company
NCT05803421
Repository of Phase Signals for Pulmonary Hypertension Algorithm Development
Analytics For Life
NCT04031989
Mediators of Atherosclerosis in South Asians Living in America
University of California, San Francisco
NCT01207167
Novel Strategies for Reducing Heart Disease Risk Disparities
University of Pittsburgh
NCT00143923
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
Eli Lilly and Company
NCT05882045
CardioSeq: Impact of WGS in Individuals With CVD
Illumina
NCT05656183
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
Medtronic Vascular
NCT05198674
Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)
Johns Hopkins University
NCT06347484
TRISCEND II Pivotal Trial
Edwards Lifesciences
NCT04482062
A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.
University of Utah
NCT06423365
Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health
American College of Radiology
NCT06055972
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 18 |
| Phase 3 | 13 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cardiovascular Diseases Trial Landscape
304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).
Phase mix: 26 late (III/IV) vs 28 early (I/II).
Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cardiovascular Diseases?
PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cardiovascular Diseases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.