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ClinicalTrials.gov 134 recruiting now official registry

Cardiovascular Diseases clinical trials

134 of 304 indexed Cardiovascular Diseases trials are currently recruiting.

304 US clinical trials · 134 currently recruiting

Cardiovascular Diseases is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 134 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 10 of these trials.

The research picture

Cardiovascular Diseases has 304 registered US clinical trials, 134 of them open to new participants right now, about 44% of the total.

134
recruiting participants now
44%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
10
top sponsor: Duke University
Phase 110Phase 218Phase 313Phase 413

Active & Recent Trials

304 total, page 3 of 7

RECRUITING Phase 1 60 participants

MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes

Kalie Tommerdahl

NCT05065372

RECRUITING 60 participants

Role of Endothelial Function in SCI CVD Risk

Craig Hospital

NCT06443151

RECRUITING Phase 4 60 participants

Treatment With Aspirin After Preeclampsia: TAP Trial

Malamo Countouris

NCT06281665

RECRUITING NA 60 participants

Adapting and Testing a Novel Digital Health Tool (PREVENT) to Improve Health Behavior Counseling and Cardiovascular Health in Rural Primary Care Clinics

Washington University School of Medicine

NCT06063564

RECRUITING NA 60 participants

Role of Adiposomes in Endothelial Dysfunction

University of Illinois at Chicago

NCT05199454

RECRUITING NA 60 participants

Designing and Assessing a Women Only Cardiac Rehabilitation (CARE) Program

University of Michigan

NCT06784895

RECRUITING NA 60 participants

HIIT Effects on Cardiometabolic Health

Syracuse University

NCT05838950

RECRUITING 60 participants

The Weight of Cardiovascular Disease

Mayo Clinic

NCT06053645

RECRUITING NA 60 participants

ADAPT Micro-Randomized Trial

University of Michigan

NCT06915220

RECRUITING NA 52 participants

The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health

Penn State University

NCT06216678

RECRUITING NA 50 participants

Personalized GI Motility Responses to Diet

University of Illinois at Urbana-Champaign

NCT06386471

RECRUITING NA 50 participants

Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

Northwestern University

NCT05082402

RECRUITING NA 50 participants

Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

Massachusetts General Hospital

NCT06001814

RECRUITING NA 40 participants

Identifying Strategies to Reduce Cardiovascular Risk Among Mothers of Young Children

NYU Langone Health

NCT06796075

RECRUITING NA 40 participants

Ketogenic Diet in Healthy Adults With Differing BMI

Penn State University

NCT06515912

RECRUITING 36 participants

PKP2-ACM Natural History Study

Rocket Pharmaceuticals

NCT06644742

RECRUITING NA 32 participants

Sleep and Circadian Mechanisms in Hypertension

Oregon Health and Science University

NCT05184933

RECRUITING NA 30 participants

Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy

University of Utah

NCT05826925

RECRUITING Phase 4 30 participants

NSAIDs vs. Coxibs in the Presence of Aspirin

Inova Health Care Services

NCT03699293

RECRUITING NA 30 participants

A Pilot Feasibility and Acceptability Study of Remote ExerciSe Training mOdalities (PRESTO)

NYU Langone Health

NCT06931470

RECRUITING NA 30 participants

Remote Vinyasa Yoga Program for Heart Health

West Virginia University

NCT06961981

RECRUITING NA 30 participants

WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time

Arizona State University

NCT06963736

RECRUITING NA 26 participants

Role of Aging and Individual Variation in Exercise Training Responsiveness

Duke University

NCT06471569

RECRUITING NA 25 participants

Evaluating Infrasonic Hemodynography

Scripps Health

NCT04636892

RECRUITING Phase 2 24 participants

Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts

Nationwide Children's Hospital

NCT04467671

RECRUITING Phase 1 23 participants

Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)

University of Kansas Medical Center

NCT04715022

RECRUITING Phase 2 20 participants

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

Pulmovant

NCT07333183

RECRUITING NA 20 participants

Probiotic Effect on Dietary Nitrate to Plasma Nitrite Production ( OPEDNPN )

Wake Forest University

NCT06375694

RECRUITING NA 15 participants

The TRICURE EFS Study

TRiCares

NCT06506942

RECRUITING NA 12 participants

Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)

Kessler Foundation

NCT05731986

RECRUITING NA 10 participants

Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke

Jorge Gonzalez-Martinez

NCT06303869

RECRUITING NA 5 participants

The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

University of California, Davis

NCT06476795

RECRUITING NA 5 participants

The Effect of Transcutaneous Stimulation on Blood Pressure in Spinal Cord Injury (SCI)

Kessler Foundation

NCT05725499

RECRUITING NA 5 participants

Chardonnay Marc and Vascular Response

University of California, Davis

NCT05545865

ACTIVE NOT RECRUITING NA 3,668,428 participants

Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement

Kaiser Permanente

NCT06571747

ACTIVE NOT RECRUITING 11,737 participants

Bogalusa Heart Study

Tulane University

NCT00005129

ACTIVE NOT RECRUITING 6,340 participants

University of North Carolina Alumni Heart Study

Duke University

NCT00005398

ACTIVE NOT RECRUITING 5,888 participants

Cardiovascular Health Study (CHS)

National Heart, Lung, and Blood Institute (NHLBI)

NCT00005133

ACTIVE NOT RECRUITING 5,306 participants

The Jackson Heart Study of Cardiovascular Disease Among African Americans

National Heart, Lung, and Blood Institute (NHLBI)

NCT00005485

ACTIVE NOT RECRUITING Phase 3 2,749 participants

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Eli Lilly and Company

NCT05803421

ACTIVE NOT RECRUITING NA 2,500 participants

Repository of Phase Signals for Pulmonary Hypertension Algorithm Development

Analytics For Life

NCT04031989

ACTIVE NOT RECRUITING 2,314 participants

Mediators of Atherosclerosis in South Asians Living in America

University of California, San Francisco

NCT01207167

ACTIVE NOT RECRUITING NA 2,000 participants

Novel Strategies for Reducing Heart Disease Risk Disparities

University of Pittsburgh

NCT00143923

ACTIVE NOT RECRUITING Phase 3 1,800 participants

A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Eli Lilly and Company

NCT05882045

ACTIVE NOT RECRUITING NA 1,500 participants

CardioSeq: Impact of WGS in Individuals With CVD

Illumina

NCT05656183

ACTIVE NOT RECRUITING NA 1,300 participants

SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN

Medtronic Vascular

NCT05198674

ACTIVE NOT RECRUITING NA 1,000 participants

Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)

Johns Hopkins University

NCT06347484

ACTIVE NOT RECRUITING NA 864 participants

TRISCEND II Pivotal Trial

Edwards Lifesciences

NCT04482062

ACTIVE NOT RECRUITING NA 816 participants

A Tool to Help Patients With Muscle Symptoms After Taking a Statin Medication.

University of Utah

NCT06423365

ACTIVE NOT RECRUITING NA 800 participants

Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular Health

American College of Radiology

NCT06055972

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Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 18
Phase 3 13
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiovascular Diseases Trial Landscape

304 indexed Cardiovascular Diseases studies · 134 recruiting (44%).

Phase mix: 26 late (III/IV) vs 28 early (I/II).

Top sponsor: Duke University (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiovascular Diseases?

PlainTrial tracks 304 US clinical trials for Cardiovascular Diseases, of which 134 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiovascular Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.