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NCT00242255 · ClinicalTrials.gov registry record
Epigenetics in the Aging Process
A clinical trial of Aging, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- Completed
- Registry status
- 90
- Enrollment target
- 4
- Study locations
NCT00242255: Completed study of Aging, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
NCT00242255 is a study of Aging that has completed, run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The registered enrollment target is 90 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (96% lower). The trial reports 4 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00242255, a study of Aging, has completed, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- COMPLETED
- Registry status
- 90 participants
- Enrollment target
- 4
- Study locations
Study Summary
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process. DNA is the primary genetic material, responsible for transmitting information from one cell to the next or from one generation to the next. A second layer of heredity is described by the term "epigenetics." Epigenetic information is reset from one generation to the next. It works in two ways: 1) by modification of the DNA, like balloons stuck at irregular intervals onto the sides of the DNA helix that encodes genes, and 2) through specialized protein shells that wrap around some regions of DNA. As in DNA, these shells can copy themselves and can transmit instructions. Because they are used to turn genes on and off, errors in their settings cause critical misinformation to be transmitted. Aging involves many changes, such as muscle weakening, graying hair, skin wrinkling, and so forth. There are several current theories of aging, including damage to genes by oxidation, shortening of tiny structures at the ends of chromosomes called telomeres, and the ability to stretch lifespan with caloric restrictions. This study will investigate the possible role of epigenetics in aging by examining and comparing the shell-like epigenetic settings in skin cells in young adults and older individuals. Preliminary results from earlier studies show differences in these settings in younger and older people. Women between the ages of 21 and 30 years and 65 and 90 years who are undergoing breast reduction or mastectomy at Suburban Hospital in Bethesda, Maryland, may participate in this study. Tissue removed during surgery for pathological examination will also be used by researchers in this study to validate the preliminary findings noted above and to continue studies into the new area of epigenetics and aging. ...
Primary Outcome
Publication of scholarly articles describing previously unknown modes of postnatal human epigenome change and their consequences for gene expression.
Conditions Studied
Study Locations (4)
Maryland
- Suburban Hospital - Bethesda
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
District of Columbia
- GW University Medical Center - Washington D.C.
Virginia
- Virginia Commonwealth University - Richmond
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 90 participants |
| Start Date | 2008-09-23 |
| Est. Completion | 2021-02-05 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)305 total trials
What the finished NCT00242255 record still lists
NCT00242255 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 90 participants, a relatively small participant target, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 0 interventions.
NCT00242255 reports a single indexed study location in Maryland, District of Columbia, Virginia.
Frequently Asked Questions
What is clinical trial NCT00242255 about?
NCT00242255 is a clinical study titled "Epigenetics in the Aging Process". This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process. DNA is the primary genetic material, responsible for transmitting information from one cell to the next or from one generation to the next. A second ...
What is the current status of trial NCT00242255?
This trial is currently completed. The enrollment target is 90 participants. The study started on 2008-09-23. Estimated completion is 2021-02-05.
What conditions does trial NCT00242255 study?
This clinical trial studies the following conditions: Aging.
Who is sponsoring clinical trial NCT00242255?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00242255 being conducted?
This trial has 4 study locations across District of Columbia, Maryland, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00242255's enrollment target sits among peer trials
90 99th of 262 higher than 159 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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