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NCT04284553 · ClinicalTrials.gov registry record · NA

Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults

A NA study of Aging and Adverse Drug Event, sponsored by Brigham and Women's Hospital.

Completed
Registry status
NA
Development phase
216
Enrollment target
1
Study location

NCT04284553: Completed NA study of Aging and Adverse Drug Event, sponsored by Brigham and Women's Hospital.

NCT04284553 is a NA study of Aging and Adverse Drug Event that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 216 participants, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04284553, a NA study of Aging and Adverse Drug Event, has completed, sponsored by Brigham and Women's Hospital.

COMPLETED
Registry status
NA
Development phase
216 participants
Enrollment target
1
Study location

Study Summary

Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable older adults, such as confusion or sedation, leading to hospitalizations, falls, and fractures. Fortunately, most of these consequences are preventable. Physicians' lack of awareness of alternatives, ambiguous practice guidelines, and perceived pressure from patients or caregivers are among the reasons why these drugs are used more than might be optimal. Reducing inappropriate use of these drugs may be achieved through decision support tools for providers that are embedded in electronic health record (EHR) systems. While EHR strategies are widely used to support the informational needs of providers, these tools have demonstrated only modest effectiveness at improving prescribing. The effectiveness of these tools could be enhanced by leveraging principles of behavioral economics and related sciences.

Primary Outcome

This outcome is measured as a composite of 1) discontinuation of study high-risk medications (i.e., active discontinuation or lack of an order during follow-up) or 2) ordering a dose taper (for benzodiazepine or sedative hypnotics) using EHR data by the primary care provider included in the study arm. If any of these actions occurred by the primary care provider, then the patient was considered to have had a change in prescribing (i.e., a reduction in inappropriate prescribing). This outcome was

Interventions

  • OTHER Order Entry
  • OTHER Open Encounter
  • OTHER Follow-up booster Alert
  • OTHER Cold State outreach
  • OTHER Simplified

Study Locations (1)

Massachusetts

  • Atrius Health - Braintree

Trial Details

FieldValue
Enrollment Target 216 participants
Start Date 2020-10-13
Est. Completion 2022-08-31
Phase NA
Brigham and Women's Hospital

937 total trials

What the finished NCT04284553 record still lists

NCT04284553 is an interventional study that assigns participants to a tested intervention. The registered 216 participants enrollment target is mid-sized for trials with a published cap, below the 2,194-participant average among 262 other Aging trials with a reported enrollment target (90% lower).

The record links to 4 conditions, with Aging appearing as the primary indexed condition, and to 5 interventions - of which Order Entry is the first listed.

NCT04284553 reports a single indexed study location in Massachusetts.

Frequently Asked Questions

What is clinical trial NCT04284553 about?

NCT04284553 is a clinical study titled "Optimizing Electronic Health Record Prompts With Behavioral Economics to Improve Prescribing for Older Adults". Prescribing of potentially unsafe medications for older adults is extremely common; benzodiazepines and sedative hypnotics are, for example, key drug classes frequently implicated in adverse health consequences for vulnerable older adults, such as confusion or sedation, leading to hospitalizations, ...

What is the current status of trial NCT04284553?

This trial is currently completed. It is a NA study. The enrollment target is 216 participants. The study started on 2020-10-13. Estimated completion is 2022-08-31.

What conditions does trial NCT04284553 study?

This clinical trial studies the following conditions: Aging, Adverse Drug Event, Benzodiazepine Sedative Adverse Reaction, Anticholinergic Adverse Reaction.

What interventions are being tested in trial NCT04284553?

The interventions under investigation include: Order Entry (OTHER), Open Encounter (OTHER), Follow-up booster Alert (OTHER), Cold State outreach (OTHER), Simplified (OTHER).

Who is sponsoring clinical trial NCT04284553?

This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04284553 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Aging

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04284553's enrollment target sits among peer trials

216 46th of 262 higher than 217 of 262 other Aging trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT04284553, the US trial registry maintained by the National Library of Medicine. NCT04284553 (mid enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.