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NCT03803904 · ClinicalTrials.gov registry record · NA
Aerobic Exercise and Cerebrovascular Function
A NA study of Aging, sponsored by VA Office of Research and Development.
- Active
- Registry status
- NA
- Development phase
- 37
- Enrollment target
- 1
- Study location
NCT03803904: Active NA study of Aging, sponsored by VA Office of Research and Development.
NCT03803904 is a NA study of Aging that is active but no longer recruiting, run by VA Office of Research and Development. The registered enrollment target is 37 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03803904, a NA study of Aging, is active but no longer recruiting, sponsored by VA Office of Research and Development.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 37 participants
- Enrollment target
- 1
- Study location
Study Summary
This proposal will evaluate two brain health measures, cerebrovascular perfusion and cerebrovascular reactivity (CVR), before and after a proven, interval-based, aerobic exercise intervention in older Veterans. The hypothesis is that the 12-week aerobic exercise intervention (Spin) will increase perfusion and improve CVR in brain regions susceptible to age-related decline. This information will inform the impact of exercise on cerebrovascular health which is known to be negatively impacted in aging and implicated in the development of neurodegenerative disease. This information will also aid the investigators' continued efforts of clinical implementation of evidence-based exercise interventions in the local Atlanta VA and surround region.
Primary Outcome
CVR will be assessed using 5% CO2 challenge while continuously acquiring MR images. This method has been extensively used and is the most suitable vasoactive stimulus. Briefly, the CO2 air (5% CO2, 21% O2 and 74% N2) will be administered via an air bag with a valve to switch between room air and CO2 air in the bag. A mouth piece and a nose clip will be used to achieve mouth-only breathing. A research staff member will be inside the magnet room throughout the experiment to switch the valve and to
Conditions Studied
Interventions
- OTHER Spin
Study Locations (1)
Georgia
- Atlanta VA Medical and Rehab Center, Decatur, GA - Decatur
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2019-04-01 |
| Est. Completion | 2026-05-01 |
| Phase | NA |
What the registry record for NCT03803904 still lists
NCT03803904 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 1 intervention - of which Spin is the first listed.
NCT03803904 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT03803904 about?
NCT03803904 is a clinical study titled "Aerobic Exercise and Cerebrovascular Function". This proposal will evaluate two brain health measures, cerebrovascular perfusion and cerebrovascular reactivity (CVR), before and after a proven, interval-based, aerobic exercise intervention in older Veterans. The hypothesis is that the 12-week aerobic exercise intervention (Spin) will increase per...
What is the current status of trial NCT03803904?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 37 participants. The study started on 2019-04-01. Estimated completion is 2026-05-01.
What conditions does trial NCT03803904 study?
This clinical trial studies the following conditions: Aging.
What interventions are being tested in trial NCT03803904?
The interventions under investigation include: Spin (OTHER).
Who is sponsoring clinical trial NCT03803904?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03803904 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aging
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03803904's enrollment target sits among peer trials
37 180th of 262 higher than 83 of 262 other Aging trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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