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NCT04276805 · ClinicalTrials.gov registry record · NA

Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

A NA study of Aging, sponsored by University of Florida.

Active
Registry status
NA
Development phase
7
Enrollment target
2
Study locations

NCT04276805: Active NA study of Aging, sponsored by University of Florida.

NCT04276805 is a NA study of Aging that is active but no longer recruiting, run by University of Florida. The registered enrollment target is 7 participants, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04276805, a NA study of Aging, is active but no longer recruiting, sponsored by University of Florida.

ACTIVE NOT RECRUITING
Registry status
NA
Development phase
7 participants
Enrollment target
2
Study locations

Study Summary

We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it can be delayed, reduced, or even reversed. The present proposal is designed to evaluate the pairing of cognitive training with a non-invasive neurostimulation technology that has shown promise in both increasing neuroplasticity and in enhancing cognitive performance, transcutaneous vagal nerve stimulation (tVNS).

Primary Outcome

The Hopkins Verbal Learning Test (HVLT-R) is a verbal learning and memory task with a 12-item word list learned over 3 trials. The total immediate recall score is the sum of correct words recalled after each of the 3 learning trials, which can range from 0 to 36.

Conditions Studied

Aging

Interventions

  • DEVICE Transcutaneous vagal nerve stimulation (tVNS)
  • BEHAVIORAL cognitive training

Study Locations (2)

Arizona

  • University of Arizona - Tucson

Florida

  • University of Florida - Gainesville

Trial Details

FieldValue
Enrollment Target 7 participants
Start Date 2020-11-17
Est. Completion 2025-10-30
Phase NA
University of Florida

1,106 total trials

What the registry record for NCT04276805 still lists

NCT04276805 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 7 participants, a relatively small participant target, below the 2,195-participant average among 262 other Aging trials with a reported enrollment target (100% lower).

The record links to 1 condition, with Aging appearing as the primary indexed condition, and to 2 interventions - of which Transcutaneous vagal nerve stimulation (tVNS) is the first listed.

NCT04276805 reports a single indexed study location in Arizona, Florida.

Frequently Asked Questions

What is clinical trial NCT04276805 about?

NCT04276805 is a clinical study titled "Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults". We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it can be delayed, reduced, or even reversed. The present proposal is designed to evaluate the pairing of cognitive training with a non-invasive neurostimulation technology that has sho...

What is the current status of trial NCT04276805?

This trial is currently active not recruiting. It is a NA study. The enrollment target is 7 participants. The study started on 2020-11-17. Estimated completion is 2025-10-30.

What conditions does trial NCT04276805 study?

This clinical trial studies the following conditions: Aging.

What interventions are being tested in trial NCT04276805?

The interventions under investigation include: Transcutaneous vagal nerve stimulation (tVNS) (DEVICE), cognitive training (BEHAVIORAL).

Who is sponsoring clinical trial NCT04276805?

This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04276805 being conducted?

This trial has 2 study locations across Arizona, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Aging

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04276805's enrollment target sits among peer trials

7 262nd of 262 higher than 1 of 262 other Aging trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Aging trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT04276805, the US trial registry maintained by the National Library of Medicine. NCT04276805 (small enrollment · single site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.