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ClinicalTrials.gov 126 recruiting now official registry

Aging clinical trials

126 of 263 indexed Aging trials are currently recruiting.

263 US clinical trials · 126 currently recruiting

Aging is the subject of 263 registered US clinical trials on ClinicalTrials.gov, 126 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is University of Florida, running 14 of these trials.

The research picture

Aging has 263 registered US clinical trials, 126 of them open to new participants right now, about 48% of the total.

126
recruiting participants now
48%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
14
top sponsor: University of Florida
Phase 129Phase 219Phase 36Phase 48

Active & Recent Trials

263 total, page 5 of 6

COMPLETED NA 66 participants

Effect of Music and Other Audio Recordings for Chronic Pain in Aging Adults

Baylor University

NCT04785963

COMPLETED Phase 2 64 participants

Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age

Gladwin, Mark, MD

NCT04405180

COMPLETED NA 61 participants

The Short-term Effects of Noninvasive Electrical Brain Stimulation on Dual Tasking in Older Adults

Hebrew SeniorLife

NCT03191812

COMPLETED NA 61 participants

The Effect of Long Duration Exercise on the Diastolic Function of the Heart

University of Texas Southwestern Medical Center

NCT02039154

COMPLETED NA 60 participants

Mindfulness Training in Healthy Older Veterans

VA Office of Research and Development

NCT02816723

COMPLETED 58 participants

Variability of Physical Assessments in an Older Population That is Overweight or Obese

Versanis Bio

NCT05174923

COMPLETED NA 58 participants

Effect of Resvida, a Comparison With Calorie Restriction Regimen

Washington University School of Medicine

NCT00823381

COMPLETED NA 56 participants

Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans

National Institute on Aging (NIA)

NCT00099697

COMPLETED NA 56 participants

Program for African American Cognition & Exercise

Pennington Biomedical Research Center

NCT03474302

COMPLETED NA 53 participants

E-training of Inmate Peer Caregivers for Enhancing Geriatric and End-of-life Care in Prisons

Klein Buendel

NCT05017129

COMPLETED Phase 2 53 participants

The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial

University of Southern California

NCT00605072

COMPLETED NA 50 participants

The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age

Big Bold Health, PBC

NCT05234203

COMPLETED NA 50 participants

Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV

Massachusetts General Hospital

NCT05434741

COMPLETED NA 46 participants

Breathing Room Intervention to Achieve Better Lung Health in Older Adults

University of Wisconsin, Milwaukee

NCT05330780

COMPLETED NA 46 participants

Emotion Study/Substudy: Flexible Brain Study

University of Florida

NCT03872414

COMPLETED NA 46 participants

The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

South Dakota State University

NCT04127240

COMPLETED NA 46 participants

Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise

Northern Arizona University

NCT03419988

COMPLETED NA 46 participants

NanoSilk Cosmo: Evaluation of a Novel Silk Complex on Biophysical Parameters Related to Skin Aging

University of Colorado, Denver

NCT04630418

COMPLETED NA 44 participants

The Effects of Added Sugar Intake on Brain Blood Flow and Hippocampal Function in Midlife Adults

University of Delaware

NCT05211726

COMPLETED Phase 1 44 participants

CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

National Institute on Aging (NIA)

NCT00099099

COMPLETED NA 43 participants

Cognitive Effects of Transcranial Direct Current Stimulation in Older Adults

Johns Hopkins University

NCT01611103

COMPLETED NA 41 participants

Role of Centrum® Silver® in Improving Micronutrient Status in Older Men

Oregon State University

NCT03004807

COMPLETED NA 41 participants

The Influence of Regular Beef Consumption and Protein Density of the Diet on Training-induced Gains in Muscle Strength and Performance in Healthy Adults

University of Illinois at Urbana-Champaign

NCT03029975

COMPLETED Phase 2 40 participants

Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty

TNF Pharmaceuticals

NCT05283486

COMPLETED NA 40 participants

Daily Activity Study of Health: Increasing Physical Activity in Aging

Northeastern University

NCT04315363

COMPLETED Early Phase 1 40 participants

Mindfulness Meditation in Older Adults

University of California, Los Angeles

NCT01532596

COMPLETED NA 34 participants

HOMEStudy: Development of a Home-based Self-delivered Prehabilitation Intervention to Proactively Reduce Fall Risk in Older Adults

University of Florida

NCT05583578

COMPLETED NA 33 participants

SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults

University of Florida

NCT05377411

COMPLETED NA 32 participants

Efficacy of Pre-sleep or Post-exercise Protein During 12 Weeks of Resistance Exercise Training

Florida State University

NCT05922475

COMPLETED NA 30 participants

Interval Training, Inflammation and Immune Function

Duke University

NCT02441205

COMPLETED NA 30 participants

Buck Institute Ketone Ester RCT

Buck Institute for Research on Aging

NCT05585762

COMPLETED NA 29 participants

Nitrate and Exercise Performance in Middle to Older Aged Adults

Wake Forest University

NCT03371966

COMPLETED NA 29 participants

Optimizing tDCS to Improve Dual Task Gait and Balance

Hebrew SeniorLife

NCT04295798

COMPLETED NA 28 participants

Inspiratory Muscle Training in Postmenopausal Women

Indiana University

NCT06459674

COMPLETED 28 participants

Innovative Imaging of Cerebrum and Muscle (iCAM) Repeatability Study

Ohio University

NCT03548168

COMPLETED NA 28 participants

Developing a Trauma-focused Intervention for Older Adults Living With HIV

University of South Carolina

NCT05287230

COMPLETED NA 28 participants

Exercise Effects on Word Learning

VA Office of Research and Development

NCT03370471

COMPLETED NA 26 participants

SimpleC Wellness Platform With Social Robot Interaction

SimpleC

NCT05296239

COMPLETED NA 26 participants

The Effects of Exercise on Sleep and Brain Health

Massachusetts General Hospital

NCT04210882

COMPLETED NA 24 participants

Effects of Aronia Berries on Vascular Endothelial Function and the Gut Microbiota in Middle-Aged/Older Adults

Colorado State University

NCT03824041

COMPLETED 24 participants

Novel Methodology to Measure Protein Accumulation

Mayo Clinic

NCT01505621

COMPLETED Phase 1 23 participants

The Physiologic Effects of Intranasal Oxytocin on Sarcopenic Obesity

Sara Espinoza

NCT03119610

COMPLETED NA 23 participants

Role of Mitochondrial-derived Oxidative Stress to Promote Vascular Endothelial Dysfunction in Non-exercisers With Aging

Ball State University

NCT05872139

COMPLETED Early Phase 1 22 participants

Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock

The University of Texas Health Science Center at San Antonio

NCT04608448

COMPLETED NA 22 participants

Aging and Gastrointestinal Barrier Function

University of Texas Southwestern Medical Center

NCT05816551

COMPLETED NA 22 participants

Coconut Sugar Lowers Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults

Ball State University

NCT05645991

COMPLETED NA 20 participants

Brain Changes With Game Training in Aging

University of Wisconsin, Madison

NCT02490137

COMPLETED NA 20 participants

Sex Differences in Vascular Responses to Exercise

University of Florida

NCT04128215

COMPLETED NA 20 participants

Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population

Leryn Reynolds

NCT04812392

COMPLETED NA 20 participants

Aerobic Exercise to Improve Executive Language Function In Older Adults

US Department of Veterans Affairs

NCT00979069

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Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 19
Phase 3 6
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Aging Trial Landscape

263 indexed Aging studies · 126 recruiting (48%).

Phase mix: 14 late (III/IV) vs 48 early (I/II).

Top sponsor: University of Florida (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Aging?

PlainTrial tracks 263 US clinical trials for Aging, of which 126 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Aging?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.