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ClinicalTrials.gov 70 recruiting now official registry

Advanced Solid Tumors clinical trials

70 of 145 indexed Advanced Solid Tumors trials are currently recruiting.

145 US clinical trials · 70 currently recruiting

Advanced Solid Tumors is the subject of 145 registered US clinical trials on ClinicalTrials.gov, 70 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 144 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Advanced Solid Tumors has 145 registered US clinical trials, 70 of them open to new participants right now, about 48% of the total.

70
recruiting participants now
48%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 1137Phase 27Phase 31

Active & Recent Trials

145 total, page 1 of 3

RECRUITING Phase 2 4,200 participants

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

American Society of Clinical Oncology

NCT02693535

RECRUITING Phase 1 933 participants

A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

Regeneron Pharmaceuticals

NCT04626635

RECRUITING Phase 1 862 participants

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

DualityBio

NCT05914116

RECRUITING Phase 1 830 participants

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

Merck Sharp & Dohme

NCT05067283

RECRUITING Phase 1 754 participants

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Revolution Medicines

NCT05379985

RECRUITING Phase 1 604 participants

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Revolution Medicines

NCT06040541

RECRUITING Phase 1 594 participants

A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

AskGene Pharma

NCT05867420

RECRUITING Phase 1 574 participants

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Revolution Medicines

NCT07349537

RECRUITING Phase 1 414 participants

A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

NextCure

NCT06792552

RECRUITING Phase 1 413 participants

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT06697197

RECRUITING Phase 1 408 participants

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT05836324

RECRUITING Phase 1 370 participants

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Revolution Medicines

NCT07397338

RECRUITING Phase 1 366 participants

A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together With Either Pembrolizumab, Standard Therapies, or Both, in Adults With Solid Tumors

Astellas Pharma Global Development

NCT05083481

RECRUITING Phase 1 365 participants

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

Marengo Therapeutics

NCT05592626

RECRUITING Phase 1 361 participants

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

ModernaTX

NCT05533697

RECRUITING Phase 1 360 participants

A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors

Bristol-Myers Squibb

NCT06730750

RECRUITING Phase 1 320 participants

SNV4818 in Participants With Advanced Solid Tumors

Pikavation Therapeutics

NCT06736704

RECRUITING Phase 1 310 participants

A Study of BG-C477 in Participants With Advanced Solid Tumors

BeOne Medicines

NCT06596473

RECRUITING Phase 1 300 participants

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

LigaChem Biosciences

NCT05941507

RECRUITING Phase 1 295 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

Vividion Therapeutics

NCT06004245

RECRUITING Phase 1 294 participants

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

Jacobio Pharmaceuticals Co.

NCT06973564

RECRUITING Phase 1 290 participants

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors

Vividion Therapeutics

NCT05954312

RECRUITING Phase 1 270 participants

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

Merck Sharp & Dohme

NCT06818643

RECRUITING Phase 1 254 participants

Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

Gilead Sciences

NCT06167317

RECRUITING Phase 1 252 participants

A Clinical Study of YL205 in Patients With Advanced Solid Tumors

MediLink Therapeutics (Suzhou) Co.

NCT06459973

RECRUITING Phase 1 250 participants

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

Tubulis

NCT06657222

RECRUITING Phase 1 240 participants

An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors

Teva Branded Pharmaceutical Products R&D

NCT06480552

RECRUITING Phase 1 240 participants

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

Regeneron Pharmaceuticals

NCT06413680

RECRUITING Phase 1 233 participants

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

Ensem Therapeutics

NCT06993844

RECRUITING Phase 1 220 participants

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors

Vividion Therapeutics

NCT06804824

RECRUITING Phase 1 213 participants

A Study of BMS-986484 Alone and Combination Therapy in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT06544655

RECRUITING Phase 1 210 participants

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Astellas Pharma Global Development

NCT05719558

RECRUITING Phase 1 200 participants

First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

OnKure

NCT06239467

RECRUITING Phase 1 200 participants

A Study of JNJ-87890387 for Advanced Solid Tumors

Janssen Research & Development

NCT06178614

RECRUITING Phase 1 188 participants

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

Alterome Therapeutics

NCT06835569

RECRUITING Phase 2 178 participants

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

Abion

NCT05541822

RECRUITING Phase 1 178 participants

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

Merck Sharp & Dohme

NCT05853367

RECRUITING Phase 1 177 participants

A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors.

Sun Pharma Advanced Research Company Limited

NCT07042100

RECRUITING Phase 1 171 participants

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

SEED Therapeutics

NCT07197554

RECRUITING Phase 1 170 participants

A Study of OTP-01, a Dual Paratopic PD-1/VEGFR2 Antibody, in Patients With Advanced Solid Tumors

Ottimo Pharma Limited

NCT07266428

RECRUITING Phase 1 165 participants

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pheon Therapeutics

NCT07127874

RECRUITING Phase 1 160 participants

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Eikon Therapeutics

NCT07262619

RECRUITING Phase 1 155 participants

A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

MediLink Therapeutics (Suzhou) Co.

NCT06384352

RECRUITING Phase 1 155 participants

A Study of PHST001 in Advanced Solid Tumors

Pheast Therapeutics

NCT06840886

RECRUITING Phase 1 154 participants

Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

Gilead Sciences

NCT06532565

RECRUITING Phase 1 145 participants

A Study of ZW191 in Participants With Solid Tumors

Zymeworks BC

NCT06555744

RECRUITING Phase 1 138 participants

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

EMD Serono Research & Development Institute

NCT07360314

RECRUITING Phase 1 130 participants

A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.

Eikon Therapeutics

NCT06907043

RECRUITING Phase 1 124 participants

A Study of MGC028 in Participants With Advanced Solid Tumors

MacroGenics

NCT06723236

RECRUITING Phase 1 121 participants

Trial to Evaluate the Safety and Preliminary Efficacy of GEN1079 in Participants With Advanced Solid Tumors

Genmab

NCT07387068

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Phase Distribution

PhaseTrial count
Phase 1 137
Phase 2 7
Phase 3 1

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumors Trial Landscape

145 indexed Advanced Solid Tumors studies · 70 recruiting (48%).

Phase mix: 1 late (III/IV) vs 144 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumors?

PlainTrial tracks 145 US clinical trials for Advanced Solid Tumors, of which 70 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.