Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 47 recruiting now official registry

PreDiabetes clinical trials

47 of 90 indexed PreDiabetes trials are currently recruiting.

90 US clinical trials · 47 currently recruiting

PreDiabetes is the subject of 90 registered US clinical trials on ClinicalTrials.gov, 47 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Ohio State University, running 5 of these trials.

The research picture

PreDiabetes has 90 registered US clinical trials, 47 of them open to new participants right now, about 52% of the total.

47
recruiting participants now
52%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
5
top sponsor: Ohio State University
Phase 11Phase 24Phase 43

Active & Recent Trials

90 total, page 1 of 2

RECRUITING NA 15,732 participants

Diabetes Clinical Decision Support

Milton S. Hershey Medical Center

NCT05447806

RECRUITING 10,000 participants

Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility

Brooklyn Clinical Research

NCT06412536

RECRUITING NA 7,500 participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Cleerly

NCT06112418

RECRUITING 7,000 participants

Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.

Clindove Research

NCT07106879

RECRUITING 1,250 participants

Blood Markers of Early Pancreas Cancer

University of Nebraska

NCT03568630

RECRUITING NA 722 participants

Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics

Tulane University

NCT06116149

RECRUITING NA 400 participants

Fresh Takes!: An Evaluation of the Impact of Receiving Fresh Food Boxes

Montefiore Medical Center

NCT06019624

RECRUITING Phase 2 360 participants

Social Determinants and a Diabetes Prevention Program Tailored for African Americans

University of Missouri, Kansas City

NCT05301413

RECRUITING NA 340 participants

Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention

Ohio State University

NCT06055036

RECRUITING Phase 4 300 participants

Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes

The University of Texas Health Science Center, Houston

NCT05119179

RECRUITING NA 216 participants

Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial

University of Minnesota

NCT06365723

RECRUITING NA 200 participants

Food as Medicine for HIV and Diabetes

University of North Carolina, Chapel Hill

NCT05026723

RECRUITING NA 200 participants

Human Immunodeficiency Virus (HIV) Food Insecurities

Wake Forest University Health Sciences

NCT04943861

RECRUITING 175 participants

Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents

University of Michigan

NCT06007404

RECRUITING NA 160 participants

Cleaner Air for Lower Cardiometabolic Risk

NYU Langone Health

NCT05994937

RECRUITING NA 160 participants

Rural Alliance for Diabetes Prevention

University of Kansas Medical Center

NCT06252038

RECRUITING NA 144 participants

MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes

University of Alabama at Birmingham

NCT03504683

RECRUITING NA 110 participants

Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance

Stanford University

NCT05165706

RECRUITING NA 100 participants

Post Prandial Individual Responses to Different Foods

Stanford University

NCT06989164

RECRUITING NA 84 participants

The YMCA Healthy Lifestyle Program for Prediabetes

Young Men's Christian Association of the Blue Water Area

NCT06841796

RECRUITING NA 80 participants

Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes

Baylor College of Medicine

NCT06782906

RECRUITING NA 80 participants

New T-UP: Engaging Vulnerable Students in Diabetes Prevention

University of California, Los Angeles

NCT07225218

RECRUITING NA 75 participants

Effect of Meal Composition and Timing Modification on Glucose Metabolism, Body Temperature and Sleep

Stanford University

NCT05413928

RECRUITING NA 72 participants

Peanuts for Cardiometabolic, Brain, and Intestinal Health

Georgia State University

NCT06867198

RECRUITING NA 70 participants

Night Owl Metabolism

Johns Hopkins University

NCT06507722

RECRUITING NA 70 participants

CGM Dynamic Index for Predicting Prediabetes in Cystic Fibrosis

Indiana University

NCT06642610

RECRUITING Phase 2 65 participants

Mechanisms for Activation of Beige Adipose Tissue in Humans

Philip Kern

NCT04666636

RECRUITING Phase 2 60 participants

The Role of Islet GLP-1 in the Pathogenesis of Prediabetes

Mayo Clinic

NCT06967558

RECRUITING NA 60 participants

Insulin and Insulin Pulses During Fasting

Mayo Clinic

NCT06424015

RECRUITING NA 60 participants

Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes

Mayo Clinic

NCT06424106

RECRUITING NA 60 participants

How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes

University of Nevada, Las Vegas

NCT06817252

RECRUITING NA 54 participants

Effects of Dihydroberberine (DHB) on GLP-1, Glycemic Control, Appetite, and Mood in Adults With Pre-Diabetes

Nanjing Nutrabuilding Bio-tech Co.

NCT07210684

RECRUITING NA 50 participants

Continuous Glucose Monitoring (CGM) in Prediabetes With Health Education Videos: Cohort 3

David S Black, PhD

NCT07477249

RECRUITING NA 40 participants

Ketogenic Diet and Diabetes Demonstration Project

University of New Mexi

NCT06115265

RECRUITING NA 40 participants

Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans

University of Delaware

NCT07450118

RECRUITING NA 40 participants

Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes

University of Hawaii

NCT07120334

RECRUITING NA 32 participants

Dinner Time for Obesity and Prediabetes

Johns Hopkins University

NCT05745441

RECRUITING 30 participants

Glucose Variability and Cognition in Prediabetes

University of Maryland, Baltimore

NCT04201600

RECRUITING NA 30 participants

Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes

Vanderbilt University

NCT06482944

RECRUITING NA 30 participants

Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes

University of California, San Diego

NCT07478263

RECRUITING NA 30 participants

WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time

Arizona State University

NCT06963736

RECRUITING NA 30 participants

Development of an Inclusive Adaptive Treatment Strategy for Weight Loss in People With Prediabetes Using a Sequential Multiple Assignment Randomized Trial

University of Alabama at Birmingham

NCT06976307

RECRUITING 20 participants

Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population

Massachusetts General Hospital

NCT05799222

RECRUITING NA 20 participants

Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center

Cedars-Sinai Medical Center

NCT06897982

RECRUITING NA 20 participants

Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

Cambridge Health Alliance

NCT06988462

RECRUITING NA 20 participants

Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic Adults

University of Arkansas

NCT06025292

RECRUITING NA 15 participants

CGM and Lifestyle Changes in Patients With Impaired Glucose Tolerance

Nemours Children's Clinic

NCT05387551

ACTIVE NOT RECRUITING NA 960 participants

Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care

Northwestern University

NCT04869917

ACTIVE NOT RECRUITING 500 participants

Evaluation of a Telehealth DPP With Medicare Patients at the University of Mississippi Medical Center

University of Mississippi Medical Center

NCT04822480

ACTIVE NOT RECRUITING NA 451 participants

Randomized Trial of Exercise Promotion in Primary Care

Kaiser Permanente

NCT04445168

Page 1 of 2 Next →

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 4
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the PreDiabetes Trial Landscape

90 indexed PreDiabetes studies · 47 recruiting (52%).

Phase mix: 3 late (III/IV) vs 5 early (I/II).

Top sponsor: Ohio State University (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for PreDiabetes?

PlainTrial tracks 90 US clinical trials for PreDiabetes, of which 47 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for PreDiabetes?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.