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PreDiabetes clinical trials
Every US clinical trial registered for PreDiabetes — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
58 US clinical trials · 31 currently recruiting
The research picture
PreDiabetes has 58 registered US clinical trials, 31 of them open to new participants right now — about 53% of the total.
- 31
- recruiting participants now
- 53%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 3
- top sponsor: Kaiser Permanente
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Diabetes Clinical Decision Support
Milton S. Hershey Medical Center
NCT05447806
Triage Survey for Cardiovascular, Obesity, and Related Endocrine Trial Eligibility
Brooklyn Clinical Research
NCT06412536
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
Cleerly
NCT06112418
Blood Markers of Early Pancreas Cancer
University of Nebraska
NCT03568630
Strategies for Implementing a Postpartum Lifestyle Intervention in WIC Clinics
Tulane University
NCT06116149
Fresh Takes!: An Evaluation of the Impact of Receiving Fresh Food Boxes
Montefiore Medical Center
NCT06019624
Social Determinants and a Diabetes Prevention Program Tailored for African Americans
University of Missouri, Kansas City
NCT05301413
Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Ohio State University
NCT06055036
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
The University of Texas Health Science Center, Houston
NCT05119179
Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
University of Minnesota
NCT06365723
Food as Medicine for HIV and Diabetes
University of North Carolina, Chapel Hill
NCT05026723
Human Immunodeficiency Virus (HIV) Food Insecurities
Wake Forest University Health Sciences
NCT04943861
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
University of Michigan
NCT06007404
Cleaner Air for Lower Cardiometabolic Risk
NYU Langone Health
NCT05994937
Rural Alliance for Diabetes Prevention
University of Kansas Medical Center
NCT06252038
MEAL TIMING Study: Effect of Time-Restricted Feeding on 24-hour Glycemic Control, Blood Pressure, and Cardiovascular Disease Risk Factors in Adults With Prediabetes
University of Alabama at Birmingham
NCT03504683
Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance
Stanford University
NCT05165706
Post Prandial Individual Responses to Different Foods
Stanford University
NCT06989164
The YMCA Healthy Lifestyle Program for Prediabetes
Young Men's Christian Association of the Blue Water Area
NCT06841796
Effect of Meal Composition and Timing Modification on Glucose Metabolism, Body Temperature and Sleep
Stanford University
NCT05413928
Night Owl Metabolism
Johns Hopkins University
NCT06507722
Mechanisms for Activation of Beige Adipose Tissue in Humans
Philip Kern
NCT04666636
The Role of Islet GLP-1 in the Pathogenesis of Prediabetes
Mayo Clinic
NCT06967558
Insulin and Insulin Pulses During Fasting
Mayo Clinic
NCT06424015
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Mayo Clinic
NCT06424106
Ketogenic Diet and Diabetes Demonstration Project
University of New Mexi
NCT06115265
Dinner Time for Obesity and Prediabetes
Johns Hopkins University
NCT05745441
Glucose Variability and Cognition in Prediabetes
University of Maryland, Baltimore
NCT04201600
Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes
Vanderbilt University
NCT06482944
Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population
Massachusetts General Hospital
NCT05799222
Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center
Cedars-Sinai Medical Center
NCT06897982
Behavioral Nudges for Diabetes Prevention (BEGIN) Trial in Primary Care
Northwestern University
NCT04869917
Evaluation of a Telehealth DPP With Medicare Patients at the University of Mississippi Medical Center
University of Mississippi Medical Center
NCT04822480
Randomized Trial of Exercise Promotion in Primary Care
Kaiser Permanente
NCT04445168
Promoting Successful Weight Loss in Primary Care in Louisiana Using Information Technology
Pennington Biomedical Research Center
NCT05523375
Technology-Supported Treatment of Sleep Apnea in Prediabetes
University of Chicago
NCT04225507
The Inspiring Action to Prevent Diabetes Intervention
University of Michigan
NCT06001801
Mastering Diabetes Study
Ohio University
NCT04454957
An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer
St. Jude Children's Research Hospital
NCT04742751
The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African Americans
Ohio State University
NCT03938389
Examining the Effects of Vivo on Physical Function and Glycemic Level in Sedentary Older With Prediabetes.
Impactiv
NCT06458530
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
Ohio State University
NCT05318183
Use of Empagliflozin to Treat Prediabetes
Oregon State University
NCT05426525
Recreational Basketball to Increase Participation in Diabetes Prevention
Kaiser Permanente
NCT05066542
Monounsaturated Fatty Acid Supplementation for Overweight and Obese Individuals With Prediabetes
Brigham and Women's Hospital
NCT05560971
Is the Degree of Perceived Effort During Resistance Exercise Important for Improvements in Blood Glucose
University of New Mexi
NCT06208189
Comparison of Outreach Methods to Encourage Enrollment in Diabetes Prevention and Weight Management Programs
Kaiser Permanente
NCT03200535
Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance
University of Michigan
NCT05055219
Patient-centered Goal Setting in the National Diabetes Prevention Program
Denver Health and Hospital Authority
NCT05559515
T-UP: Engaging Vulnerable Students in Diabetes Prevention
University of California, Los Angeles
NCT06385015
Diabetes Risk Education and Communication Trial
Northwestern University
NCT03283657
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
Mary Ellen Vajravelu, MD
NCT05404711
CGM Plus GEM in Prediabetes
University of Colorado, Denver
NCT05580978
Family Diabetes Prevention Program Pilot Study
Johns Hopkins University
NCT05358444
Women's Lifestyle Balance Study
University of California, San Francis
NCT03184337
Maternal Health Diabetes Prevention Study
Tulane University
NCT05343494
WorkWell: Work-based Activity and Metabolic Health
Arizona State University
NCT04269070
Morning Light Treatment to Improve Glucose Metabolism
Northwestern University
NCT03188263
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 4 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the PreDiabetes Trial Landscape
ClinicalTrials.gov lists 58 US studies indexed under PreDiabetes, and 31 of those are currently open to recruitment — roughly 53% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for PreDiabetes shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 4 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for PreDiabetes is led by Kaiser Permanente with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 58 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for PreDiabetes?
PlainTrial tracks 58 US clinical trials for PreDiabetes, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for PreDiabetes?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.