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RECRUITING Phase 1

Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)

NCT05853367 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to assess the efficacy, safety, and tolerability of MK-0472 administered as monotherapy and in combination with pembrolizumab (MK-3475) or MK-1084 in participants with histologically or cytologically confirmed diagnosis of advanced/metastatic solid tumors.

Interventions

  • BIOLOGICAL Pembrolizumab
  • DRUG MK-1084
  • DRUG MK-0472

Study Locations (20)

Other

  • Rambam Health Care Campus ( Site 0304) — Haifa
  • Shaare Zedek Medical Center ( Site 0303) — Jerusalem
  • Rabin Medical Center ( Site 0301) — Petah Tikva
  • Sheba Medical Center ( Site 0300) — Ramat Gan
  • Sourasky Medical Center ( Site 0302) — Tel Aviv

Region M. de Santiago

  • Centro de Estudios Clínicos SAGA ( Site 0701) — Santiago
  • Fundacion Arturo Lopez Perez ( Site 0700) — Santiago
  • Centro de Investigacion Clinicadela Universidad Catolica ( Site 0703) — Santiago
  • Bradfordhill ( Site 0702) — Santiago

New Jersey

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0001) — Hackensack
  • Rutgers Cancer Institute of New Jersey ( Site 0005) — New Brunswick

Quebec

  • Centre Hospitalier de l'Université de Montréal-Unit for Innovative Therapies ( Site 0100) — Montreal
  • Jewish General Hospital ( Site 0104) — Montreal

Illinois

  • Northwestern Memorial Hospital ( Site 0002) — Chicago

Kentucky

  • The University of Louisville, James Graham Brown Cancer Center ( Site 0004) — Louisville

Ontario

  • Princess Margaret Cancer Centre ( Site 0101) — Toronto

Masovian Voivodeship

  • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0401) — Warsaw

Trial Details

FieldValue
Enrollment Target 178 participants
Start Date 2023-07-06
Est. Completion 2028-02-12
Phase Phase 1

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05853367

The ClinicalTrials.gov registry entry for NCT05853367 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 178 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Advanced Solid Tumors appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05853367 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Other, Region M. de Santiago, New Jersey. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05853367 about?

NCT05853367 is a clinical study titled "Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)". The purpose of this study is to assess the efficacy, safety, and tolerability of MK-0472 administered as monotherapy and in combination with pembrolizumab (MK-3475) or MK-1084 in participants with histologically or cytologically confirmed diagnosis of advanced/metastatic solid tumors.

What is the current status of trial NCT05853367?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 178 participants. The study started on 2023-07-06. Estimated completion is 2028-02-12.

What conditions does trial NCT05853367 study?

This clinical trial studies the following conditions: Advanced Solid Tumors, Metastatic Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05853367?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), MK-1084 (DRUG), MK-0472 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05853367?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05853367 being conducted?

This trial has 20 study locations across Illinois, Kentucky, New Jersey, Ontario, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial