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ClinicalTrials.gov 70 recruiting now official registry

Advanced Solid Tumors clinical trials

70 of 145 indexed Advanced Solid Tumors trials are currently recruiting.

145 US clinical trials · 70 currently recruiting

Advanced Solid Tumors is the subject of 145 registered US clinical trials on ClinicalTrials.gov, 70 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 144 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Advanced Solid Tumors has 145 registered US clinical trials, 70 of them open to new participants right now, about 48% of the total.

70
recruiting participants now
48%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 1137Phase 27Phase 31

Active & Recent Trials

145 total, page 2 of 3

RECRUITING Phase 1 120 participants

A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer, Extra-Pulmonary Small Cell Neuroendocrine Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors

National Cancer Institute (NCI)

NCT04826341

RECRUITING Phase 1 116 participants

Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT04222413

RECRUITING Phase 2 111 participants

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Bayer

NCT06760819

RECRUITING Phase 1 110 participants

A Clinical Trial to Evaluate the Safety, Tolerability and Clinical Efficacy of M3T01 Monotherapy and in Combination With Pembrolizumab and Other Systemic Therapies

Providence Health & Services

NCT06719362

RECRUITING Phase 1 110 participants

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

Auricula Biosciences

NCT07148128

RECRUITING Phase 1 100 participants

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Tyra Biosciences

NCT06915753

RECRUITING Phase 1 90 participants

First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, in Patients With Advanced or Metastatic Solid Tumors, Including Ovarian Cancer

Accent Therapeutics

NCT06799065

RECRUITING Phase 1 83 participants

A Trial TO Evaluate THE Safety, Tolerability, Pharmacokinetics, AND Efficacy OF Shr-a1904 IN Subjects With Advanced Solid Tumors

Jiangsu HengRui Medicine Co.

NCT05277168

RECRUITING Phase 1 80 participants

A Study of ATG-031 in Advanced Solid Tumors or B-cell Non-Hodgkin Lymphomas

Antengene Biologics Limited

NCT06028373

RECRUITING Phase 1 60 participants

Pan-RAS Inhibitor YL-17231 in Patients With Advanced Solid Tumors Harboring Mutations in KRAS, HRAS, or NRAS

Shanghai YingLi Pharmaceutical Co.

NCT06096974

RECRUITING Phase 1 50 participants

Dose Escalation and Expansion Study Evaluating ODC-IL2 in Adult Patients With Advanced or Metastatic Solid Tumors

Trutino Biosciences

NCT06770764

RECRUITING Phase 1 50 participants

Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TGW101 in Participants With Advanced Solid Tumors

Tagworks Pharmaceuticals

NCT06959706

RECRUITING Phase 1 48 participants

PAS-004 in Patients With Advanced Solid Tumors

Pasithea Therapeutics

NCT06299839

RECRUITING Phase 1 40 participants

A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

AstraZeneca

NCT07161414

RECRUITING Phase 1 40 participants

A Study of PARG Inhibitor FORX-428 in Patients With Advanced Solid Tumors.

FoRx Therapeutics

NCT07356453

RECRUITING Phase 1 30 participants

BTM-3566 in Advanced Solid Tumors

Bantam Pharmaceuticals

NCT07266285

RECRUITING Phase 1 24 participants

Study of FID-022 in Participants With Advanced Solid Tumors

Fulgent Pharma

NCT06694480

RECRUITING Phase 1 24 participants

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

Acrotech Biopharma

NCT07036133

RECRUITING Phase 2 14 participants

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

Amgen

NCT07172919

RECRUITING Phase 1 14 participants

A Study to Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

PMV Pharmaceuticals

NCT07372625

ACTIVE NOT RECRUITING Phase 1 610 participants

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

Amgen

NCT04185883

ACTIVE NOT RECRUITING Phase 1 520 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab

AbbVie

NCT05029882

ACTIVE NOT RECRUITING Phase 1 498 participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

Genentech

NCT04449874

ACTIVE NOT RECRUITING Phase 1 383 participants

A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors

MedImmune

NCT02671435

ACTIVE NOT RECRUITING Phase 1 288 participants

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

AbbVie

NCT05599984

ACTIVE NOT RECRUITING Phase 1 284 participants

A First-in-human Study to Learn How Safe the Study Drug BAY2965501 is, Find the Best Dose (Single Drug & Combination), How it Affects the Body, What Maximum Amount Can be Given, How it Moves Into, Through and Out of the Body, How it Acts on Different Tumors in Participants With Advanced Solid Tumors

Bayer

NCT05614102

ACTIVE NOT RECRUITING Phase 1 237 participants

QTX3544 in Patients With Advanced Solid Tumors With KRAS G12V Mutations

Quanta Therapeutics

NCT06715124

ACTIVE NOT RECRUITING Phase 1 210 participants

A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Advanced Solid Tumors

Hoffmann-La Roche

NCT05593094

ACTIVE NOT RECRUITING Phase 1 150 participants

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

AbbVie

NCT03893955

ACTIVE NOT RECRUITING Phase 1 134 participants

A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations

Atavistik Bio

NCT07038369

ACTIVE NOT RECRUITING Phase 1 129 participants

A Study of MRG002 in Patients with HER2-Positive Advanced Solid Tumors and Locally Advanced or Metastatic Gastric/Gastroesophageal Junction (GEJ) Cancer

Shanghai Miracogen

NCT04492488

ACTIVE NOT RECRUITING Phase 1 129 participants

A First-in-human Study to Learn How Safe the Study Drug BAY3375968, an Anti-CCR8 Antibody, is, When Given Alone or in Combination With Pembrolizumab, How it Affects the Body, How it Moves Into, Through, and Out of the Body, and to Find the Best Dose in Participants With Advanced Solid Tumors

Bayer

NCT05537740

ACTIVE NOT RECRUITING Phase 1 125 participants

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors

Vividion Therapeutics

NCT06188208

ACTIVE NOT RECRUITING Phase 1 120 participants

Rollover Study for Continued Safety and Tolerability in Subjects Treated With Spartalizumab Alone or in Combination With Other Study Treatments

Novartis Pharmaceuticals

NCT04058756

ACTIVE NOT RECRUITING Phase 2 109 participants

A Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects With Advanced Solid Tumors and Subsequent Dose Expansion Cohorts

Promontory Therapeutics

NCT02266745

ACTIVE NOT RECRUITING Phase 1 100 participants

A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors

Bristol-Myers Squibb

NCT05888831

ACTIVE NOT RECRUITING Phase 1 100 participants

A Study to Evaluate Safety and Tolerability of BPT567 in Patients With Advanced Solid Tumors

Bright Peak Therapeutics

NCT06779851

ACTIVE NOT RECRUITING Phase 1 96 participants

A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors Including Merkel Cell Carcinoma

Fujifilm Pharmaceuticals U.S.A.

NCT04047251

ACTIVE NOT RECRUITING Phase 1 90 participants

A Phase 1 Dose-escalation Study of FF-10832 for Treatment of Solid Tumors Including Biliary Tract Cancer

Fujifilm Pharmaceuticals U.S.A.

NCT03440450

ACTIVE NOT RECRUITING Phase 1 77 participants

A Study of AMG 355 Alone and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

Amgen

NCT06131398

ACTIVE NOT RECRUITING Phase 1 66 participants

A Study to Evaluate Safety and Preliminary Anti-tumor Activity of Debio 0123 as Monotherapy in Adult Participants With Advanced Solid Tumors

Debiopharm International

NCT05109975

ACTIVE NOT RECRUITING Phase 1 57 participants

A Study of mRNA-4106 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Solid Tumors

ModernaTX

NCT06880549

ACTIVE NOT RECRUITING Phase 1 9 participants

A Study to Evaluate INCB177054 in Participants With Select Advanced or Metastatic Solid Tumors

Incyte Corporation

NCT06873789

COMPLETED Phase 2 345 participants

Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors

PharmaMar

NCT02454972

COMPLETED Phase 1 313 participants

Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers

Five Prime Therapeutics

NCT02526017

COMPLETED Phase 1 292 participants

Study of DS-8201a in Subjects With Advanced Solid Malignant Tumors

Daiichi Sankyo Co.

NCT02564900

COMPLETED Phase 1 182 participants

A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors

AbbVie

NCT03000257

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED Phase 1 147 participants

A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors

Sumitomo Pharma America

NCT02432326

COMPLETED Phase 1 136 participants

Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies

BioMed Valley Discoveries

NCT01781429

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Phase Distribution

PhaseTrial count
Phase 1 137
Phase 2 7
Phase 3 1

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumors Trial Landscape

145 indexed Advanced Solid Tumors studies · 70 recruiting (48%).

Phase mix: 1 late (III/IV) vs 144 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumors?

PlainTrial tracks 145 US clinical trials for Advanced Solid Tumors, of which 70 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.