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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
NCT06040541 · View on ClinicalTrials.gov ↗
Study Summary
This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.
Conditions Studied
Interventions
- DRUG RMC-6236
- DRUG RMC-9805
Study Locations (17)
Texas
- Sarah Cannon Research Institute at Mary Crowley — Dallas
- University of Texas, MD Anderson Cancer Center — Houston
- START — San Antonio
Florida
- Florida Cancer Specialists — Sarasota
- Lee Moffitt Cancer Center — Tampa
Massachusetts
- Massachusetts General Hospital — Boston
- Dana-Farber Cancer Institute — Boston
New York
- NYU Langone — New York
- Memorial Sloan Kettering Cancer Center — New York
North Carolina
- Duke Cancer Center — Durham
- Carolina BioOncology Institute — Huntersville
California
- University of California, Davis Comprehensive Cancer Center — Sacramento
Connecticut
- Smilow Cancer Hospital (Yale University) — New Haven
Maryland
- Johns Hopkins University — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 604 participants |
| Start Date | 2023-09-07 |
| Est. Completion | 2027-04-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06040541
The ClinicalTrials.gov registry entry for NCT06040541 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 604 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Revolution Medicines, which has 66 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Advanced Solid Tumors appearing as the primary indexed condition, and to 2 interventions — of which RMC-6236 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06040541 reports 17 study locations spanning 11 distinct geographic areas — top geographies include Texas, Florida, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06040541 about?
NCT06040541 is a clinical study titled "Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors". This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.
What is the current status of trial NCT06040541?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 604 participants. The study started on 2023-09-07. Estimated completion is 2027-04-30.
What conditions does trial NCT06040541 study?
This clinical trial studies the following conditions: Advanced Solid Tumors, Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06040541?
The interventions under investigation include: RMC-6236 (DRUG), RMC-9805 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06040541?
This trial is sponsored by Revolution Medicines, which has 66 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06040541 being conducted?
This trial has 17 study locations across California, Connecticut, Florida, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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