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RECRUITING Phase 2

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

NCT02693535 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers). \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* Results in publication or poster presentation format are posted as they become available for individual cohorts at www.tapur.org/news. The results may be accessed at any time. All results will be made available on clinicaltrials.gov at the end of the study. Indexing of available results on PubMed is in progress. \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*

Interventions

  • DRUG Sunitinib
  • DRUG Palbociclib
  • DRUG Temsirolimus
  • DRUG Trastuzumab and Pertuzumab
  • DRUG Vemurafenib and Cobimetinib

Study Locations (20)

California

  • Sutter Auburn — Auburn
  • Sutter Alta Bates — Berkeley
  • The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate — Los Angeles
  • Kaiser Permanente - Oakland Medical Center — Oakland
  • Sutter Palo Alto Medical Foundation: Palo Alto — Palo Alto
  • Kaiser Permanente - Roseville Medical Center — Roseville
  • Sutter Roseville — Roseville
  • Kaiser Permanente - Sacramento Medical Center — Sacramento
  • Sutter Sacramento — Sacramento
  • Kaiser Permanente - South San Francisco Medical Center — San Francisco
  • California Pacific Medical Center Research Institute — San Francisco
  • Kaiser Permanente - San Francisco Medical Center — San Francisco
  • Sutter Cancer Research Consortium — San Francisco
  • Kaiser Permanente - San Jose Medical Center — San Jose
  • Kaiser Permanente - San Leandro Medical Center — San Leandro
  • Kaiser Permanente - Santa Clara Medical Center — Santa Clara
  • Sutter Palo Alto Medical Foundation: Santa Cruz — Santa Cruz
  • Sutter Palo Alto Medical Foundation: Fremont — Santa Cruz

Alabama

  • University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham

Arizona

  • Cancer Treatment Centers of America-Phoenix — Phoenix

Trial Details

FieldValue
Enrollment Target 4,200 participants
Start Date 2016-03-14
Est. Completion 2028-12-31
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02693535

The ClinicalTrials.gov registry entry for NCT02693535 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 4,200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is American Society of Clinical Oncology, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Sunitinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02693535 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02693535 about?

NCT02693535 is a clinical study titled "TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer". The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE: Due to character limits, the arms section does NOT include ...

What is the current status of trial NCT02693535?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 4,200 participants. The study started on 2016-03-14. Estimated completion is 2028-12-31.

What conditions does trial NCT02693535 study?

This clinical trial studies the following conditions: Multiple Myeloma, Advanced Solid Tumors, Lymphoma, Non-Hodgkin. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02693535?

The interventions under investigation include: Sunitinib (DRUG), Palbociclib (DRUG), Temsirolimus (DRUG), Trastuzumab and Pertuzumab (DRUG), Vemurafenib and Cobimetinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02693535?

This trial is sponsored by American Society of Clinical Oncology, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02693535 being conducted?

This trial has 20 study locations across Alabama, Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial