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NCT05541822 · ClinicalTrials.gov registry record · Phase 2
To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation
A Phase 2 study of Advanced Solid Tumors, sponsored by Abion.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 178
- Enrollment target
- 20
- Study locations
NCT05541822: Recruiting Phase 2 study of Advanced Solid Tumors, sponsored by Abion.
NCT05541822 is a Phase 2 study of Advanced Solid Tumors that is actively recruiting participants, run by Abion. The registered enrollment target is 178 participants, below the 197-participant average among 144 other Advanced Solid Tumors trials with a reported enrollment target (10% lower). The trial reports 20 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05541822, a Phase 2 study of Advanced Solid Tumors, is actively recruiting participants, sponsored by Abion.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 178 participants
- Enrollment target
- 20
- Study locations
Study Summary
ABN401-003 is a Phase 2 clinical study to assess efficacy, safety, tolerability and pharmacokinetic profile of ABN401 (vabametkib) in specific populations of advance solid tumors with c-MET alterations as monotherapy.
Primary Outcome
ORR is defined as the proportion of patients who experience a complete response (CR) or partial response (PR) as measured by RECIST 1.1
Conditions Studied
Interventions
- DRUG Lazertinib
- DRUG Vabametkib
Study Locations (20)
Other
- Chungbuk National University Hospital - Cheongju-si
- Gachon University Gil Medical Center - Incheon
- Gyeongsang National University Hospital - Jinju
- Seoul National University Bundang Hospital - Seongnam-si
- Kangbuk Samsung Hospital - Seoul
- Asan Medical Center - Seoul
- Samsung Medical Center - Seoul
- The Catholic University of Korea, Seoul St Mary's Hospitals - Seoul
- The Catholic University of Korea St Vincents Hospital - Suwon
- China Medical University Hospital - Taichung
- National Cheng Kung University Hospital - Tainan
Seoul
- Boramae Medical Center - Dongjak
- Korea University Anam Hospital - Seoul
- Severance Hospital - Sinchon-dong
Florida
- Cancer Care of North Florida, PA (Lake City Cancer Care, LLC) - Medical Oncology - Lake City
- Mid Florida Center - Orange City
Gyeonggi-do
- National Cancer Center - Goyang-si
- Ajou University Hospital - Suwon
Michigan
- The Henry Ford Cancer Institute - Detroit
Texas
- The University of Texas MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2023-01-17 |
| Est. Completion | 2029-02 |
| Phase | Phase 2 |
What NCT05541822 shows while recruiting
NCT05541822 is an interventional study that assigns participants to a tested intervention. The registered 178 participants enrollment target is mid-sized for trials with a published cap, below the 197-participant average among 144 other Advanced Solid Tumors trials with a reported enrollment target (10% lower).
The record links to 1 condition, with Advanced Solid Tumors appearing as the primary indexed condition, and to 2 interventions - of which Lazertinib is the first listed.
NCT05541822 names 20 study sites across 6 states, led by Other, Seoul, Florida.
Frequently Asked Questions
What is clinical trial NCT05541822 about?
NCT05541822 is a clinical study titled "To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation". ABN401-003 is a Phase 2 clinical study to assess efficacy, safety, tolerability and pharmacokinetic profile of ABN401 (vabametkib) in specific populations of advance solid tumors with c-MET alterations as monotherapy.
What is the current status of trial NCT05541822?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 178 participants. The study started on 2023-01-17. Estimated completion is 2029-02.
What conditions does trial NCT05541822 study?
This clinical trial studies the following conditions: Advanced Solid Tumors.
What interventions are being tested in trial NCT05541822?
The interventions under investigation include: Lazertinib (DRUG), Vabametkib (DRUG).
Who is sponsoring clinical trial NCT05541822?
This trial is sponsored by Abion, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05541822 being conducted?
This trial has 20 study locations across Florida, Michigan, Texas, Gyeonggi-do, Seoul. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumors
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05541822's enrollment target sits among peer trials
178 48th of 144 higher than 96 of 144 other Advanced Solid Tumors trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumors trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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