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To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation
NCT05541822 · View on ClinicalTrials.gov ↗
Study Summary
ABN401-003 is a Phase 2 clinical study to assess efficacy, safety, tolerability and pharmacokinetic profile of ABN401 (vabametkib) in specific populations of advance solid tumors with c-MET alterations as monotherapy.
Conditions Studied
Interventions
- DRUG Lazertinib
- DRUG Vabametkib
Study Locations (20)
Other
- Chungbuk National University Hospital — Cheongju-si
- Gachon University Gil Medical Center — Incheon
- Gyeongsang National University Hospital — Jinju
- Seoul National University Bundang Hospital — Seongnam-si
- Kangbuk Samsung Hospital — Seoul
- Asan Medical Center — Seoul
- Samsung Medical Center — Seoul
- The Catholic University of Korea, Seoul St Mary's Hospitals — Seoul
- The Catholic University of Korea St Vincents Hospital — Suwon
- China Medical University Hospital — Taichung
- National Cheng Kung University Hospital — Tainan
Seoul
- Boramae Medical Center — Dongjak
- Korea University Anam Hospital — Seoul
- Severance Hospital — Sinchon-dong
Florida
- Cancer Care of North Florida, PA (Lake City Cancer Care, LLC) - Medical Oncology — Lake City
- Mid Florida Center — Orange City
Gyeonggi-do
- National Cancer Center — Goyang-si
- Ajou University Hospital — Suwon
Michigan
- The Henry Ford Cancer Institute — Detroit
Texas
- The University of Texas MD Anderson Cancer Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2023-01-17 |
| Est. Completion | 2029-02 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05541822
The ClinicalTrials.gov registry entry for NCT05541822 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 178 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Abion, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumors appearing as the primary indexed condition, and to 2 interventions — of which Lazertinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05541822 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Other, Seoul, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05541822 about?
NCT05541822 is a clinical study titled "To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation". ABN401-003 is a Phase 2 clinical study to assess efficacy, safety, tolerability and pharmacokinetic profile of ABN401 (vabametkib) in specific populations of advance solid tumors with c-MET alterations as monotherapy.
What is the current status of trial NCT05541822?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 178 participants. The study started on 2023-01-17. Estimated completion is 2029-02.
What conditions does trial NCT05541822 study?
This clinical trial studies the following conditions: Advanced Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05541822?
The interventions under investigation include: Lazertinib (DRUG), Vabametkib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05541822?
This trial is sponsored by Abion, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05541822 being conducted?
This trial has 20 study locations across Florida, Michigan, Texas, Gyeonggi-do, Seoul. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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