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RECRUITING Phase 1

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

NCT05836324 · View on ClinicalTrials.gov ↗

Study Summary

To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid tumors.

Interventions

  • DRUG Cetuximab
  • DRUG FOLFIRI
  • DRUG FOLFOX
  • DRUG bevacizumab
  • DRUG INCA33890

Study Locations (20)

Other

  • Rigshospitalet Uni of Hospital of Copenhagen — Copenhagen
  • Herlev Og Gentofte Hospital — Herlev
  • Odense University Hospital — Odense C
  • Vejle Hospital — Vejle
  • Centre Leon Berard — Lyon
  • Institut Gustave Roussy — Villejuif
  • Fondazione Irccs Istituto Nazionale Dei Tumori — Milan
  • Irccs Istituto Clinico Humanitas — Rozzano
  • Centro Ricerche Cliniche Di Verona — Verona

California

  • The Angeles Clinic and Research Institute — Los Angeles
  • Valkyrie Clinical Trials — Los Angeles

New York

  • Nyu Langone Health - Long Island Hospital — Mineola
  • Laura and Isaac Perlmutter Cancer Center — New York

Texas

  • University of Texas Md Anderson Cancer Center — Houston
  • South Texas Accelerated Research Therapeutics — San Antonio

Massachusetts

  • Dana Farber Cancer Institute — Boston

Michigan

  • Cancer and Hematology Centers of Western Michigan-Start Midwest — Grand Rapids

New Jersey

  • Hackensack University Medical Center — Hackensack

Pennsylvania

  • University of Pennsylvania — Philadelphia

Trial Details

FieldValue
Enrollment Target 408 participants
Start Date 2023-07-24
Est. Completion 2027-01-13
Phase Phase 1

Sponsor

Incyte Corporation

163 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05836324

The ClinicalTrials.gov registry entry for NCT05836324 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 408 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Incyte Corporation, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Advanced Solid Tumors appearing as the primary indexed condition, and to 5 interventions — of which Cetuximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05836324 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05836324 about?

NCT05836324 is a clinical study titled "A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors". To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid tumors.

What is the current status of trial NCT05836324?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 408 participants. The study started on 2023-07-24. Estimated completion is 2027-01-13.

What conditions does trial NCT05836324 study?

This clinical trial studies the following conditions: Advanced Solid Tumors, Solid Tumors, Metastatic Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05836324?

The interventions under investigation include: Cetuximab (DRUG), FOLFIRI (DRUG), FOLFOX (DRUG), bevacizumab (DRUG), INCA33890 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05836324?

This trial is sponsored by Incyte Corporation, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05836324 being conducted?

This trial has 20 study locations across California, Massachusetts, Michigan, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial