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ClinicalTrials.gov 65 recruiting now official registry

Hepatocellular Carcinoma clinical trials

65 of 146 indexed Hepatocellular Carcinoma trials are currently recruiting.

146 US clinical trials · 65 currently recruiting

Hepatocellular Carcinoma is the subject of 146 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 8 of these trials.

The research picture

Hepatocellular Carcinoma has 146 registered US clinical trials, 65 of them open to new participants right now, about 45% of the total.

65
recruiting participants now
45%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: AstraZeneca
Phase 147Phase 245Phase 317Phase 43

Active & Recent Trials

146 total, page 1 of 3

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING 1,600 participants

Molecular Basis of Pediatric Liver Cancer

University of Pittsburgh

NCT03959800

RECRUITING Phase 3 1,220 participants

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

AstraZeneca

NCT06921785

RECRUITING 1,200 participants

Multi-analyte Blood Test Clinical Trial

Helio Genomics

NCT05199259

RECRUITING 730 participants

Multilevel Determinants of Socioeconomic Disparities in Geographic Late-Stage Hepatocellular Carcinoma Hotspots

University of Southern California

NCT07312162

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 2 660 participants

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

AbbVie

NCT06109272

RECRUITING NA 600 participants

CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules

University of Texas Southwestern Medical Center

NCT06184152

RECRUITING 500 participants

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

National Cancer Institute (NCI)

NCT04145141

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 3 471 participants

Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis

Can-Fite BioPharma

NCT05201404

RECRUITING 400 participants

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

City of Hope Medical Center

NCT06342414

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING Phase 1 304 participants

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

AstraZeneca

NCT06795022

RECRUITING Phase 2 294 participants

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

AstraZeneca

NCT05775159

RECRUITING Phase 2 200 participants

Liver Cancer Disparities in American Indian and Alaska Native Persons

University of Washington

NCT05304234

RECRUITING Phase 1 178 participants

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

Tvardi Therapeutics, Incorporated

NCT05440708

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 2 126 participants

Adjuvant IP-001 Treatment for HCC Patients Following Surgical Resection and Ablation or Ablation Alone

Robert C. Martin

NCT06526338

RECRUITING Phase 1 117 participants

Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies

Anwaar Saeed

NCT03539822

RECRUITING NA 100 participants

Targeted Navigation in Hepatocellular Carcinoma (HCC)

University of Miami

NCT06260943

RECRUITING Phase 1 100 participants

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Nammi Therapeutics

NCT06582017

RECRUITING Phase 1 100 participants

A Study of ZW251 in Participants With Advanced Solid Tumors

Zymeworks BC

NCT07164313

RECRUITING 100 participants

Impact of "Teaching the Teachers" Concept on Global Education and Application of Hepatocellular Carcinoma Diagnosis Guidelines

M.D. Anderson Cancer Center

NCT05143619

RECRUITING Phase 2 97 participants

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Virogin Biotech Canada

NCT05223816

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 2 72 participants

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Dan Zandberg

NCT04114136

RECRUITING Phase 2 72 participants

A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

Coherus Oncology

NCT06679985

RECRUITING Phase 2 70 participants

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

Massachusetts General Hospital

NCT03482102

RECRUITING Phase 1 70 participants

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

TORL Biotherapeutics

NCT06005740

RECRUITING Phase 1 64 participants

Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

St. Jude Children's Research Hospital

NCT05468359

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING Phase 1 60 participants

A Trial Utilizing 18F-FS PG PET to Guide Therapy in Hepatocellular Carcinoma

M.D. Anderson Cancer Center

NCT07116486

RECRUITING Phase 2 60 participants

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

Replimune

NCT05733598

RECRUITING Phase 2 54 participants

Combination of TATE and PD-1 Inhibitor in Liver Cancer

Teclison

NCT03259867

RECRUITING 50 participants

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Replimune

NCT06887348

RECRUITING NA 50 participants

Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

Massachusetts General Hospital

NCT06541990

RECRUITING Phase 1 45 participants

A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC

University of Alabama at Birmingham

NCT06294548

RECRUITING Phase 2 40 participants

Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)

Anwaar Saeed

NCT06698250

RECRUITING Phase 2 40 participants

Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC

H. Lee Moffitt Cancer Center and Research Institute

NCT06553885

RECRUITING NA 40 participants

HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Montefiore Medical Center

NCT06899152

RECRUITING Phase 4 40 participants

Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant

Icahn School of Medicine at Mount Sinai

NCT07059494

RECRUITING Phase 1 38 participants

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

National Cancer Institute (NCI)

NCT05003895

RECRUITING Phase 1 36 participants

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

M.D. Anderson Cancer Center

NCT05394259

RECRUITING Phase 2 35 participants

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

University of California, Irvine

NCT04472767

RECRUITING Phase 2 32 participants

Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis

The University of Texas Health Science Center at San Antonio

NCT06526104

RECRUITING Phase 2 30 participants

Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular Carcinoma

University of Miami

NCT06902246

RECRUITING Phase 2 30 participants

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

Genentech

NCT06096779

RECRUITING Phase 2 30 participants

Y-90 Treatment Response Using Transarterial Radioembolization

Thomas Jefferson University

NCT07145801

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 45
Phase 3 17
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatocellular Carcinoma Trial Landscape

146 indexed Hepatocellular Carcinoma studies · 65 recruiting (45%).

Phase mix: 20 late (III/IV) vs 92 early (I/II).

Top sponsor: AstraZeneca (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatocellular Carcinoma?

PlainTrial tracks 146 US clinical trials for Hepatocellular Carcinoma, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.