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ClinicalTrials.gov 65 recruiting now official registry

Hepatocellular Carcinoma clinical trials

Every US clinical trial registered for Hepatocellular Carcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

146 US clinical trials · 65 currently recruiting

The research picture

Hepatocellular Carcinoma has 146 registered US clinical trials, 65 of them open to new participants right now — about 45% of the total.

65
recruiting participants now
45%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
8
top sponsor: AstraZeneca

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 1,650 participants

A Multicenter Cancer Biospecimen Collection Study

Cofactor Genomics

NCT04510129

RECRUITING 1,600 participants

Molecular Basis of Pediatric Liver Cancer

University of Pittsburgh

NCT03959800

RECRUITING Phase 3 1,220 participants

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

AstraZeneca

NCT06921785

RECRUITING 1,200 participants

Multi-analyte Blood Test Clinical Trial

Helio Genomics

NCT05199259

RECRUITING 730 participants

Multilevel Determinants of Socioeconomic Disparities in Geographic Late-Stage Hepatocellular Carcinoma Hotspots

University of Southern California

NCT07312162

RECRUITING Phase 1 714 participants

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05208762

RECRUITING Phase 2 660 participants

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

AbbVie

NCT06109272

RECRUITING NA 600 participants

CEUS vs. AMRI for HCC Detection in Patients With Indeterminate Liver Nodules

University of Texas Southwestern Medical Center

NCT06184152

RECRUITING 500 participants

National Translational Science Network of Precision-based Immunotherapy for Primary Liver Cancer

National Cancer Institute (NCI)

NCT04145141

RECRUITING 500 participants

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Mohamed Abdel-Rahman

NCT04792463

RECRUITING Phase 2 480 participants

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Diwakar Davar

NCT07223424

RECRUITING Phase 3 471 participants

Namodenoson in the Treatment of Advanced Hepatocellular Carcinoma in Patients With Child-Pugh Class B7 Cirrhosis

Can-Fite BioPharma

NCT05201404

RECRUITING 400 participants

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

City of Hope Medical Center

NCT06342414

RECRUITING Phase 2 320 participants

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

National Cancer Institute (NCI)

NCT06503146

RECRUITING Phase 1 304 participants

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

AstraZeneca

NCT06795022

RECRUITING Phase 2 294 participants

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

AstraZeneca

NCT05775159

RECRUITING Phase 2 200 participants

Liver Cancer Disparities in American Indian and Alaska Native Persons

University of Washington

NCT05304234

RECRUITING Phase 1 178 participants

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

Tvardi Therapeutics, Incorporated

NCT05440708

RECRUITING Phase 1 126 participants

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

7 Hills Pharma

NCT06362369

RECRUITING Phase 2 126 participants

Adjuvant IP-001 Treatment for HCC Patients Following Surgical Resection and Ablation or Ablation Alone

Robert C. Martin

NCT06526338

RECRUITING Phase 1 117 participants

Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies

Anwaar Saeed

NCT03539822

RECRUITING NA 100 participants

Targeted Navigation in Hepatocellular Carcinoma (HCC)

University of Miami

NCT06260943

RECRUITING Phase 1 100 participants

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Nammi Therapeutics

NCT06582017

RECRUITING Phase 1 100 participants

A Study of ZW251 in Participants With Advanced Solid Tumors

Zymeworks BC

NCT07164313

RECRUITING 100 participants

Impact of "Teaching the Teachers" Concept on Global Education and Application of Hepatocellular Carcinoma Diagnosis Guidelines

M.D. Anderson Cancer Center

NCT05143619

RECRUITING Phase 2 97 participants

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Virogin Biotech Canada

NCT05223816

RECRUITING Phase 1 78 participants

IDOV-Immune for Advanced Solid Tumors

ViroMissile

NCT06910657

RECRUITING Phase 2 72 participants

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Dan Zandberg

NCT04114136

RECRUITING Phase 2 72 participants

A Trial of Casdozokitug in Combination With Toripalimab Plus Bevacizumab in Participants With Unresectable and/or Locally Advanced or Metastatic Hepatocellular Carcinoma

Coherus Oncology

NCT06679985

RECRUITING Phase 2 70 participants

Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer

Massachusetts General Hospital

NCT03482102

RECRUITING Phase 1 70 participants

A Phase 1, First in Human Study of TORL-4-500 in Patients With Advanced Cancer

TORL Biotherapeutics

NCT06005740

RECRUITING Phase 1 64 participants

Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

St. Jude Children's Research Hospital

NCT05468359

RECRUITING Phase 1 60 participants

Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies

BioEclipse Therapeutics

NCT04282044

RECRUITING Phase 1 60 participants

A Trial Utilizing 18F-FS PG PET to Guide Therapy in Hepatocellular Carcinoma

M.D. Anderson Cancer Center

NCT07116486

RECRUITING Phase 2 60 participants

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

Replimune

NCT05733598

RECRUITING Phase 2 54 participants

Combination of TATE and PD-1 Inhibitor in Liver Cancer

Teclison

NCT03259867

RECRUITING 50 participants

A Study to Assess the Long-term Safety Outcomes in Patients Previously Treated With RP1, RP2, or RP3

Replimune

NCT06887348

RECRUITING NA 50 participants

Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

Massachusetts General Hospital

NCT06541990

RECRUITING Phase 1 45 participants

A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC

University of Alabama at Birmingham

NCT06294548

RECRUITING Phase 2 40 participants

Zanzalintinib (XL-092) Plus Durvalumab and Tremelimumab in Unresectable Hepatocellular Carcinoma (ZENOBIA)

Anwaar Saeed

NCT06698250

RECRUITING Phase 2 40 participants

Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC

H. Lee Moffitt Cancer Center and Research Institute

NCT06553885

RECRUITING NA 40 participants

HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer

Montefiore Medical Center

NCT06899152

RECRUITING Phase 4 40 participants

Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant

Icahn School of Medicine at Mount Sinai

NCT07059494

RECRUITING Phase 1 38 participants

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

National Cancer Institute (NCI)

NCT05003895

RECRUITING Phase 1 36 participants

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

M.D. Anderson Cancer Center

NCT05394259

RECRUITING Phase 2 35 participants

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

University of California, Irvine

NCT04472767

RECRUITING Phase 2 32 participants

Study of Tremelimumab and Durvalumab (MEDI4736) (T300+D) in Advanced Hepatocellular Carcinomas With Child-Pugh-B Cirrhosis

The University of Texas Health Science Center at San Antonio

NCT06526104

RECRUITING Phase 2 30 participants

Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular Carcinoma

University of Miami

NCT06902246

RECRUITING Phase 2 30 participants

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

Genentech

NCT06096779

RECRUITING Phase 2 30 participants

Y-90 Treatment Response Using Transarterial Radioembolization

Thomas Jefferson University

NCT07145801

RECRUITING Phase 1 25 participants

Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

Teclison

NCT02174549

RECRUITING Phase 4 24 participants

Atezolizumab and Bevacizumab Pre-Liver Transplantation for Patients With Hepatocellular Carcinoma Beyond Milan Criteria

The Methodist Hospital Research Institute

NCT05185505

RECRUITING Phase 1 21 participants

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

Baylor College of Medicine

NCT06198296

RECRUITING Phase 1 21 participants

Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells

Seattle Children's Hospital

NCT07148050

RECRUITING NA 20 participants

Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment

University of Tennessee

NCT03686709

RECRUITING Phase 1 20 participants

Cryoablation and Arterial Infusion of SD-101 in Combination with Durvalumab and Tremelimumab

University of California, San Diego

NCT06710223

RECRUITING Phase 1 20 participants

T-Cell Therapy (ECT204) in Adults With Advanced HCC

Eureka Therapeutics

NCT04864054

RECRUITING Phase 1 20 participants

SIRT With Tremelimumab and Durvalumab for Resectable HCC

Jiping Wang, MD, PhD

NCT05701488

RECRUITING Phase 3 20 participants

Evaluating Novel Therapies in ctDNA Positive GI Cancers

Georgetown University

NCT05482516

RECRUITING Phase 2 20 participants

A Pilot Study of Liver Protection Using Prednisone for Patients Receiving Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

University of Michigan Rogel Cancer Center

NCT05901519

RECRUITING Phase 2 19 participants

The Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma (HCC)

Inova Health Care Services

NCT06789757

RECRUITING Phase 1 18 participants

SBRT With Atezo/Bev for HCC

Abramson Cancer Center at Penn Medicine

NCT05488522

RECRUITING NA 15 participants

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

University of California, Irvine

NCT05497531

RECRUITING Phase 2 12 participants

A Prospective Study of Memantine in Patients With Cirrhosis and Liver Cancer

Inova Health Care Services

NCT06007846

RECRUITING Phase 2 12 participants

AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

University of Florida

NCT05669339

ACTIVE NOT RECRUITING 2,990 participants

ALTUS: Performance of a Multi- Target Hepatocellular Carcinoma (HCC) Test in Subjects With Increased Risk

Exact Sciences Corporation

NCT05064553

ACTIVE NOT RECRUITING 1,810 participants

Extracellular RNA Markers of Liver Disease and Cancer

Mayo Clinic

NCT02908048

ACTIVE NOT RECRUITING Phase 3 1,324 participants

Study of Durvalumab and Tremelimumab as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma

AstraZeneca

NCT03298451

ACTIVE NOT RECRUITING 1,000 participants

Registry 17-009: Multi-Institutional Study Examining Patients With HCC Undergoing Liver Transplantation

Federico Aucejo

NCT06018857

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 3 908 participants

Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

AstraZeneca

NCT03847428

ACTIVE NOT RECRUITING Phase 3 837 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Sorafenib in Participants With Advanced Hepatocellular Carcinoma (HCC) Who Have Not Received Previous Systemic Anticancer Therapy

Exelixis

NCT03755791

ACTIVE NOT RECRUITING Phase 3 760 participants

Evaluate Durvalumab and Tremelimumab +/- Lenvatinib in Combination With TACE in Patients With Locoregional HCC

AstraZeneca

NCT05301842

ACTIVE NOT RECRUITING Phase 3 732 participants

A Study of Nivolumab in Combination With Ipilimumab in Participants With Advanced Hepatocellular Carcinoma

Bristol-Myers Squibb

NCT04039607

ACTIVE NOT RECRUITING Phase 3 724 participants

A Global Study to Evaluate Transarterial Chemoembolization (TACE) in Combination With Durvalumab and Bevacizumab Therapy in Patients With Locoregional Hepatocellular Carcinoma

AstraZeneca

NCT03778957

ACTIVE NOT RECRUITING Phase 3 687 participants

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

Hoffmann-La Roche

NCT05904886

ACTIVE NOT RECRUITING Phase 3 545 participants

A Study of Nivolumab in Participants With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation

Bristol-Myers Squibb

NCT03383458

ACTIVE NOT RECRUITING Phase 3 534 participants

A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma

CStone Pharmaceuticals

NCT04194775

ACTIVE NOT RECRUITING Phase 2 433 participants

A Study of Durvalumab or Tremelimumab Monotherapy, or Durvalumab in Combination With Tremelimumab or Bevacizumab in Advanced Hepatocellular Carcinoma

MedImmune

NCT02519348

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 2 184 participants

Study of an Immunotherapeutic, DPX-Survivac, in Combination With Low Dose Cyclophosphamide & Pembrolizumab, in Subjects With Selected Advanced & Recurrent Solid Tumors

ImmunoVaccine Technologies, Inc. (IMV Inc.)

NCT03836352

ACTIVE NOT RECRUITING Phase 2 130 participants

Study to Evaluate Adverse Events, and Change in Disease Activity, When Intravenously (IV) Infused With Livmoniplimab in Combination With IV Infused Budigalimab in Adult Participants With Hepatocellular Carcinoma (HCC)

AbbVie

NCT05822752

ACTIVE NOT RECRUITING NA 120 participants

Radioembolization Trial Utilizing Eye90 Microspheres™ for the Treatment of Hepatocellular Carcinoma (HCC)

ABK Biomedical

NCT05953337

ACTIVE NOT RECRUITING Phase 2 109 participants

Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors

National Cancer Institute (NCI)

NCT02867592

ACTIVE NOT RECRUITING Phase 2 100 participants

TheraSphere With Durvalumab and Tremelimumab for HCC

Boston Scientific Corporation

NCT05063565

ACTIVE NOT RECRUITING NA 100 participants

Contrast-enhanced MRI in Detecting Benign and Malignant Liver Lesions

M.D. Anderson Cancer Center

NCT02156739

ACTIVE NOT RECRUITING Phase 1 94 participants

A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma

AstraZeneca

NCT06084884

ACTIVE NOT RECRUITING Phase 2 65 participants

Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients

Regeneron Pharmaceuticals

NCT03916627

ACTIVE NOT RECRUITING Phase 2 58 participants

Domvanalimab and Zimberelimab in Advanced Liver Cancers

University of Texas Southwestern Medical Center

NCT05724563

ACTIVE NOT RECRUITING Phase 2 52 participants

Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis

National Cancer Institute (NCI)

NCT02968810

ACTIVE NOT RECRUITING Phase 2 48 participants

Neoadjuvant Nivolumab with CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC)

Icahn School of Medicine at Mount Sinai

NCT04123379

ACTIVE NOT RECRUITING NA 47 participants

The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy

HistoSonics

NCT04572633

ACTIVE NOT RECRUITING Phase 2 45 participants

Role of Lisinopril in Preventing the Progression of Non-Alcoholic Fatty Liver Disease, RELIEF-NAFLD Study

Northwestern University

NCT04550481

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING NA 40 participants

TACE With or Without SBRT as Bridging Therapy for Pre-transplant HCC Patients

Abramson Cancer Center at Penn Medicine

NCT01918683

ACTIVE NOT RECRUITING Phase 1 36 participants

Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function

M.D. Anderson Cancer Center

NCT02626312

ACTIVE NOT RECRUITING Phase 2 35 participants

A Study of Pembrolizumab and Bavituximab in Patients With Advanced Hepatocellular Carcinoma

David Hsieh

NCT03519997

ACTIVE NOT RECRUITING Phase 1 33 participants

DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection

National Cancer Institute (NCI)

NCT02772003

ACTIVE NOT RECRUITING Phase 1 31 participants

Feasibility and Efficacy of Perioperative Nivolumab With or Without Relatlimab for Patients With Potentially Resectable Hepatocellular Carcinoma (HCC)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04658147

ACTIVE NOT RECRUITING Phase 2 30 participants

Durvalumab (MEDI4736) and Tremelimumab for Hepatocellular Carcinoma in Patients Listed for a Liver Transplant

Davendra Sohal

NCT05027425

Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 45
Phase 3 17
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hepatocellular Carcinoma Trial Landscape

ClinicalTrials.gov lists 146 US studies indexed under Hepatocellular Carcinoma, and 65 of those are currently open to recruitment — roughly 45% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Hepatocellular Carcinoma shows 20 late-stage studies (Phase 3 and Phase 4 combined) alongside 92 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Hepatocellular Carcinoma is led by AstraZeneca with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hepatocellular Carcinoma?

PlainTrial tracks 146 US clinical trials for Hepatocellular Carcinoma, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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