Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04088370 · ClinicalTrials.gov registry record
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
A clinical trial of Alcoholic Hepatitis, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT04088370: Recruiting study of Alcoholic Hepatitis, sponsored by The Cleveland Clinic.
NCT04088370 is a study of Alcoholic Hepatitis that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 30 participants, below the 295-participant average among 5 other Alcoholic Hepatitis trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04088370, a study of Alcoholic Hepatitis, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of alcoholic liver disease. In addition to the inflammatory response mitochondrial perturbations exist and redox homeostasis is altered in patients with alcoholic hepatitis. Though this is known there have been very few studies targeting mitochondrial function in Peripheral Blood Mononuclear Cells (PBMCs). We plan to collect 50 milliliters of blood from healthy control patients so that we can compare the data to that of patients with alcoholic hepatitis and those who are heavy drinkers without liver disease. In addition to studying mitochondrial function we will investigate cytokine response, as well as fatty acid metabolism, glucose, and insulin measurements
Primary Outcome
Mitochondrial Respiration will be quantified by using a standard substrate, uncoupler, inhibitor titration protocol using high resolution respirometry
Conditions Studied
Interventions
- OTHER Blood Draw
Study Locations (1)
Ohio
- Cleveland Clinic Foundation - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2019-10-08 |
| Est. Completion | 2026-12 |
What NCT04088370 shows while recruiting
NCT04088370 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 295-participant average among 5 other Alcoholic Hepatitis trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Alcoholic Hepatitis appearing as the primary indexed condition, and to 1 intervention - of which Blood Draw is the first listed.
NCT04088370 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT04088370 about?
NCT04088370 is a clinical study titled "Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis". Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of alcoholic liver disease. In addition to the inflammatory response mitochond...
What is the current status of trial NCT04088370?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2019-10-08. Estimated completion is 2026-12.
What conditions does trial NCT04088370 study?
This clinical trial studies the following conditions: Alcoholic Hepatitis.
What interventions are being tested in trial NCT04088370?
The interventions under investigation include: Blood Draw (OTHER).
Who is sponsoring clinical trial NCT04088370?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04088370 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcoholic Hepatitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Alcohol Treatment Outcomes Following Early vs. Standard Liver Transplant for SAH
RECRUITING · NA
-
Safety Evaluation of Fecal Microbiota Transplantation in Severe Alcoholic Hepatitis
RECRUITING · Phase 1
-
HA35 Moderate Alcoholic Hepatitis (AH) Study
RECRUITING · Early Phase 1
-
Investigating HepQuant DuO Test as a Biomarker in Alcohol-related Liver Disease
RECRUITING
-
Alcoholic Hepatitis Network Observational Study
COMPLETED
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00977977 · 30 participants · Phase 2
Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy
- NCT01459107 · 30 participants · Phase 2
Human Upper Extremity Allotransplantation
- NCT01666080 · 30 participants · NA
Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)
- NCT01720836 · 30 participants · Phase 1
Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI