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NCT04088370 · ClinicalTrials.gov registry record
Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis
A clinical trial of Alcoholic Hepatitis, sponsored by The Cleveland Clinic.
- Recruiting
- Registry status
- 30
- Enrollment target
- 1
- Study location
NCT04088370 is a study of Alcoholic Hepatitis that is actively recruiting participants, run by The Cleveland Clinic. The registered enrollment target is 30 participants, below the 295-participant average among 5 other Alcoholic Hepatitis trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04088370, a study of Alcoholic Hepatitis, is actively recruiting participants, sponsored by The Cleveland Clinic.
- RECRUITING
- Registry status
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of alcoholic liver disease. In addition to the inflammatory response mitochondrial perturbations exist and redox homeostasis is altered in patients with alcoholic hepatitis. Though this is known there have been very few studies targeting mitochondrial function in Peripheral Blood Mononuclear Cells (PBMCs). We plan to collect 50 milliliters of blood from healthy control patients so that we can compare the data to that of patients with alcoholic hepatitis and those who are heavy drinkers without liver disease. In addition to studying mitochondrial function we will investigate cytokine response, as well as fatty acid metabolism, glucose, and insulin measurements
Conditions Studied
Interventions
- OTHER Blood Draw
Study Locations (1)
Ohio
- Cleveland Clinic Foundation - Cleveland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2019-10-08 |
| Est. Completion | 2026-12 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04088370
The ClinicalTrials.gov registry entry for NCT04088370 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 295-participant average among 5 other Alcoholic Hepatitis trials with a reported enrollment target (90% lower). The listed sponsor is The Cleveland Clinic, which has 688 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Alcoholic Hepatitis appearing as the primary indexed condition, and to 1 intervention - of which Blood Draw is the first listed.
NCT04088370 reports 1 study location spanning 1 distinct geographic area - top geographies include Ohio.
Frequently Asked Questions
What is clinical trial NCT04088370 about?
NCT04088370 is a clinical study titled "Peripheral Blood Mononuclear Cells Response In Healthy Controls, Heavy Drinkers, and Patients With Alcoholic Hepatitis". Inflammatory responses in response to alcohol have been identified as contributing to the development of alcoholic hepatitis. The inflammatory response including that to LippoPolySaccharide is known to lead to progression of alcoholic liver disease. In addition to the inflammatory response mitochond...
What is the current status of trial NCT04088370?
This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2019-10-08. Estimated completion is 2026-12.
What conditions does trial NCT04088370 study?
This clinical trial studies the following conditions: Alcoholic Hepatitis.
What interventions are being tested in trial NCT04088370?
The interventions under investigation include: Blood Draw (OTHER).
Who is sponsoring clinical trial NCT04088370?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04088370 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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