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PTSD clinical trials
77 of 155 indexed PTSD trials are currently recruiting.
155 US clinical trials · 77 currently recruiting
PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.
The research picture
PTSD has 155 registered US clinical trials, 77 of them open to new participants right now, about 50% of the total.
- 77
- recruiting participants now
- 50%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 28
- top sponsor: VA Office of Research and Development
Active & Recent Trials
155 total, page 1 of 4
Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder
University of Chicago
NCT06479447
The ED-AWARENESS-2 Trial
Washington University School of Medicine
NCT05534243
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
George Washington University
NCT04913766
PTSD Treatment for Incarcerated Men and Women: AV
University of Wisconsin, Madison
NCT07283757
PTSD Screening in Pregnant Black Women
Emory University
NCT06522022
AIMS Medical Outcomes Study
Advanced Integrative Medical Science Institute
NCT04512755
Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers
University of Michigan
NCT05457985
A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems
University of Washington
NCT05632770
Treatments for Insomnia in Veterans With PTSD
VA Office of Research and Development
NCT05194930
A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
Stanford University
NCT06367764
Improving Behavioral Health for Caregivers and Children After Pediatric Injury
Medical University of South Carolina
NCT06856057
Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset
Rush University Medical Center
NCT05700279
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
The University of Texas Health Science Center at San Antonio
NCT07176273
Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center
Baylor Research Institute
NCT06210711
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
The University of Texas Health Science Center, Houston
NCT05368987
Evaluation of the H.O.O.V.E.S. Healing Intensives Program
VA Salt Lake City Health Care System
NCT06300255
COPEWeb Training for Providers
VA Office of Research and Development
NCT05812131
Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
Boston University
NCT05486793
A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel
Weill Medical College of Cornell University
NCT03803332
Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)
University of Rochester
NCT06956781
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
NCT06624137
Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial
VA Office of Research and Development
NCT07010757
Oxytocin to Enhance Integrated Treatment for AUD and PTSD
Medical University of South Carolina
NCT04523922
Neural Connectivity During Therapy for Adolescent PTSD
The University of Texas Health Science Center at San Antonio
NCT05423444
Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults
University of Nebraska
NCT05269459
Project Safe Guard-Trauma
University of Colorado, Denver
NCT06876740
Safe Mothers, Safe Children Initiative
New York University
NCT04752618
Non-Inferiority Trial of TrIGR for PTSD
VA Office of Research and Development
NCT05789329
Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot
Medical University of South Carolina
NCT07390786
Behavioral Health Collaborative Care Model in an ICU Recovery Clinic
Medical University of South Carolina
NCT07372586
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
University of Massachusetts, Worcester
NCT06278922
Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children
New York University
NCT06262178
A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans
VA Office of Research and Development
NCT05995678
Psychotherapy Effects on Reward Processing in PTSD
University of Texas at Austin
NCT06096740
Cognitive Control Training for Extinction in PTSD
VA Office of Research and Development
NCT06629064
The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD
University of Alabama, Tuscaloo
NCT06144203
Treatments in Women Veterans With Insomnia and PTSD
VA Office of Research and Development
NCT05683132
Cognitive Processing Therapy (CPT) Memory Support (MS) Study
Boston University
NCT05310097
Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD
Ohio State University
NCT06285708
Exercise and Emotional Learning in Posttraumatic Stress Disorder
Christal L Badour
NCT06127342
Vagal Nerve Stimulation in mTBI
VA Office of Research and Development
NCT04437498
Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder
White River Junction Veterans Affairs Medical Center
NCT05637879
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
University of Rhode Island
NCT07217795
Enhancing Rehabilitation for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT06586164
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Duke University
NCT05120635
Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series
Reset Medical and Wellness Center
NCT07473505
Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma
Paul Crawford
NCT05516862
Post-Traumatic Stress Disorder Focused Psychodynamic Psychotherapy
Montefiore Medical Center
NCT03755401
Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families
University of Illinois at Chicago
NCT06261463
Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD
VA Office of Research and Development
NCT05380050
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 22 |
| Phase 3 | 5 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the PTSD Trial Landscape
155 indexed PTSD studies · 77 recruiting (50%).
Phase mix: 10 late (III/IV) vs 29 early (I/II).
Top sponsor: VA Office of Research and Development (28 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for PTSD?
PlainTrial tracks 155 US clinical trials for PTSD, of which 77 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for PTSD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.