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ClinicalTrials.gov 77 recruiting now official registry

PTSD clinical trials

77 of 155 indexed PTSD trials are currently recruiting.

155 US clinical trials · 77 currently recruiting

PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.

The research picture

PTSD has 155 registered US clinical trials, 77 of them open to new participants right now, about 50% of the total.

77
recruiting participants now
50%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
28
top sponsor: VA Office of Research and Development
Phase 17Phase 222Phase 35Phase 45

Active & Recent Trials

155 total, page 1 of 4

RECRUITING NA 17,000 participants

Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

University of Chicago

NCT06479447

RECRUITING NA 3,090 participants

The ED-AWARENESS-2 Trial

Washington University School of Medicine

NCT05534243

RECRUITING NA 1,000 participants

REstoring Mental Health Through COmmUnity-based Psychological Services in New York City

George Washington University

NCT04913766

RECRUITING NA 900 participants

PTSD Treatment for Incarcerated Men and Women: AV

University of Wisconsin, Madison

NCT07283757

RECRUITING NA 804 participants

PTSD Screening in Pregnant Black Women

Emory University

NCT06522022

RECRUITING 500 participants

AIMS Medical Outcomes Study

Advanced Integrative Medical Science Institute

NCT04512755

RECRUITING NA 430 participants

Testing Adaptive Interventions to Improve Posttraumatic Stress Disorder Treatment Outcomes in Federally Qualified Health Centers

University of Michigan

NCT05457985

RECRUITING NA 424 participants

A Deployment Focused Pragmatic Trial of Optimal Stepped Care Intervention Targeting PTSD and Comorbidity for Acutely Hospitalized Injury Survivors Treated in US Trauma Care Systems

University of Washington

NCT05632770

RECRUITING NA 400 participants

Treatments for Insomnia in Veterans With PTSD

VA Office of Research and Development

NCT05194930

RECRUITING NA 400 participants

A Comparative Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations

Stanford University

NCT06367764

RECRUITING NA 348 participants

Improving Behavioral Health for Caregivers and Children After Pediatric Injury

Medical University of South Carolina

NCT06856057

RECRUITING NA 345 participants

Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

Rush University Medical Center

NCT05700279

RECRUITING NA 302 participants

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)

The University of Texas Health Science Center at San Antonio

NCT07176273

RECRUITING NA 300 participants

Trauma BPE Prolonged Exposure Therapy for Injured Individuals Admitted to a Level I Trauma Center

Baylor Research Institute

NCT06210711

RECRUITING NA 250 participants

Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans

The University of Texas Health Science Center, Houston

NCT05368987

RECRUITING 250 participants

Evaluation of the H.O.O.V.E.S. Healing Intensives Program

VA Salt Lake City Health Care System

NCT06300255

RECRUITING NA 248 participants

COPEWeb Training for Providers

VA Office of Research and Development

NCT05812131

RECRUITING NA 240 participants

Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study

Boston University

NCT05486793

RECRUITING NA 208 participants

A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel

Weill Medical College of Cornell University

NCT03803332

RECRUITING NA 200 participants

Multiphase Optimization Strategy (MOST) for Treating Pediatric Post-traumatic Stress Disorder (PTSD)

University of Rochester

NCT06956781

RECRUITING 200 participants

Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics

Yale University

NCT06624137

RECRUITING NA 182 participants

Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial

VA Office of Research and Development

NCT07010757

RECRUITING Phase 2 180 participants

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

Medical University of South Carolina

NCT04523922

RECRUITING NA 180 participants

Neural Connectivity During Therapy for Adolescent PTSD

The University of Texas Health Science Center at San Antonio

NCT05423444

RECRUITING Phase 2 180 participants

Safety and Efficacy of Cannabidiol (CBD) for Symptoms of PTSD in Adults

University of Nebraska

NCT05269459

RECRUITING NA 168 participants

Project Safe Guard-Trauma

University of Colorado, Denver

NCT06876740

RECRUITING NA 160 participants

Safe Mothers, Safe Children Initiative

New York University

NCT04752618

RECRUITING NA 158 participants

Non-Inferiority Trial of TrIGR for PTSD

VA Office of Research and Development

NCT05789329

RECRUITING NA 150 participants

Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot

Medical University of South Carolina

NCT07390786

RECRUITING NA 150 participants

Behavioral Health Collaborative Care Model in an ICU Recovery Clinic

Medical University of South Carolina

NCT07372586

RECRUITING NA 144 participants

Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma

University of Massachusetts, Worcester

NCT06278922

RECRUITING NA 120 participants

Parenting STAIR: Adapting a Trauma-Focused Parenting Intervention for Military-Connected Mothers and Their Children

New York University

NCT06262178

RECRUITING NA 120 participants

A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans

VA Office of Research and Development

NCT05995678

RECRUITING NA 120 participants

Psychotherapy Effects on Reward Processing in PTSD

University of Texas at Austin

NCT06096740

RECRUITING NA 120 participants

Cognitive Control Training for Extinction in PTSD

VA Office of Research and Development

NCT06629064

RECRUITING NA 120 participants

The Influence of Aerobic Exercise on Consolidation of Fear Extinction Learning in PTSD

University of Alabama, Tuscaloo

NCT06144203

RECRUITING NA 100 participants

Treatments in Women Veterans With Insomnia and PTSD

VA Office of Research and Development

NCT05683132

RECRUITING NA 100 participants

Cognitive Processing Therapy (CPT) Memory Support (MS) Study

Boston University

NCT05310097

RECRUITING NA 100 participants

Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

Ohio State University

NCT06285708

RECRUITING NA 100 participants

Exercise and Emotional Learning in Posttraumatic Stress Disorder

Christal L Badour

NCT06127342

RECRUITING NA 100 participants

Vagal Nerve Stimulation in mTBI

VA Office of Research and Development

NCT04437498

RECRUITING Phase 2 92 participants

Glecaprevir/Pibrentasvir for Post-traumatic Stress Disorder

White River Junction Veterans Affairs Medical Center

NCT05637879

RECRUITING NA 80 participants

Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building

University of Rhode Island

NCT07217795

RECRUITING NA 80 participants

Enhancing Rehabilitation for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT06586164

RECRUITING NA 80 participants

Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans

Duke University

NCT05120635

RECRUITING 75 participants

Integrative Bilateral Cervical Sympathetic Blocks for Trauma-Related Symptoms in Special Operations Veterans: A Prospective Case Series

Reset Medical and Wellness Center

NCT07473505

RECRUITING NA 75 participants

Determining the Right Acupuncture for Good Recovery Over Neuropsychiatric Trauma

Paul Crawford

NCT05516862

RECRUITING NA 75 participants

Post-Traumatic Stress Disorder Focused Psychodynamic Psychotherapy

Montefiore Medical Center

NCT03755401

RECRUITING NA 74 participants

Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

University of Illinois at Chicago

NCT06261463

RECRUITING NA 63 participants

Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD

VA Office of Research and Development

NCT05380050

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 22
Phase 3 5
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the PTSD Trial Landscape

155 indexed PTSD studies · 77 recruiting (50%).

Phase mix: 10 late (III/IV) vs 29 early (I/II).

Top sponsor: VA Office of Research and Development (28 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for PTSD?

PlainTrial tracks 155 US clinical trials for PTSD, of which 77 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for PTSD?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.