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NCT06624137 · ClinicalTrials.gov registry record
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
A clinical trial of PTSD and Healthy Volunteer, sponsored by Yale University.
- Recruiting
- Registry status
- 200
- Enrollment target
- 2
- Study locations
NCT06624137 is a study of PTSD and Healthy Volunteer that is actively recruiting participants, run by Yale University. The registered enrollment target is 200 participants, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (34% lower). The trial reports 2 study locations across 1 state.
The verdict
NCT06624137, a study of PTSD and Healthy Volunteer, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 2
- Study locations
Study Summary
The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving serotonergic psychedelics through any clinical trial at Yale University. The main questions it aims to answer are: 1. Do serotonergic psychedelics cause the brain to rely on new information more than previously learned information while under the influence? What about 1 day, 5-14 days, and 4-6 weeks after use? 2. Do serotonergic psychedelics cause long-lasting side-effects in how people perceive (see, hear, feel, etc.) the world and how easily people change their beliefs? 3. How does the brain's electrical activity change after using serotonergic psychedelics? How does the balance between excitation and inhibition change while under their effect? 4. Can changes in how the brain uses information predict who will benefit from a psychedelic and who will have side effects from psychedelics? Researchers will compare with people given placebos to see what changes in brain processing are unique to serotonergic psychedelics. Participants will have the opportunity to do some combination of the following: 1. Online computer assessments consisting of games and questionnaires that probe how participants think. 2. Magnetoencephalography (MEG) or electroencephalography (EEG) with eyes closed and with repeated clicks, images, or sensations delivered. 3. A magnetic resonance imaging (MRI) scan. 4. Semi-structured qualitative interviews about their experience after taking a serotonergic psychedelic recorded via Zoom.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Serotonergic Psychedelic
Study Locations (2)
Connecticut
- Connecticut Mental Health Center - Hamden
- West Haven VA Medical Center - West Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-12-12 |
| Est. Completion | 2028-05 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06624137
The ClinicalTrials.gov registry entry for NCT06624137 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (34% lower). The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with PTSD appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06624137 reports 2 study locations spanning 1 distinct geographic area - top geographies include Connecticut.
Frequently Asked Questions
What is clinical trial NCT06624137 about?
NCT06624137 is a clinical study titled "Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics". The goal of this observational study is to learn how the brain's information processing changes during and following administration of serotonergic psychedelics (psilocybin, N,N-Dimethyltryptamine/DMT, Lystergic Acid Diethylamide/LSD, etc.) for people with and without mental illness receiving seroto...
What is the current status of trial NCT06624137?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2024-12-12. Estimated completion is 2028-05.
What conditions does trial NCT06624137 study?
This clinical trial studies the following conditions: PTSD, Healthy Volunteer, Migraine, Tobacco Use Disorder, Alcohol Use Disorder (AUD).
What interventions are being tested in trial NCT06624137?
The interventions under investigation include: Placebo (DRUG), Serotonergic Psychedelic (DRUG).
Who is sponsoring clinical trial NCT06624137?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06624137 being conducted?
This trial has 2 study locations across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.