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ClinicalTrials.gov 77 recruiting now official registry

PTSD clinical trials

77 of 155 indexed PTSD trials are currently recruiting.

155 US clinical trials · 77 currently recruiting

PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.

The research picture

PTSD has 155 registered US clinical trials, 77 of them open to new participants right now, about 50% of the total.

77
recruiting participants now
50%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
28
top sponsor: VA Office of Research and Development
Phase 17Phase 222Phase 35Phase 45

Active & Recent Trials

155 total, page 2 of 4

RECRUITING NA 62 participants

Adolescent Stress and Substance Intervention Subsequent to Trauma

Rhode Island Hospital

NCT07197476

RECRUITING NA 60 participants

Self-Management Interventions After an ICD Shock

University of Washington

NCT06037785

RECRUITING Phase 1 50 participants

Open-Label Psilocybin Study in Transdiagnostic Population

Yale University

NCT06442423

RECRUITING NA 50 participants

Biomarkers in the Retina for Prognosticating Mental Health Treatments

VA Puget Sound Health Care System

NCT06363968

RECRUITING NA 45 participants

Positive Processes and Transition to Health - Single-Session (PATH-SS)

Case Western Reserve University

NCT06900712

RECRUITING Phase 2 42 participants

Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

Stanford University

NCT06577636

RECRUITING Phase 2 40 participants

Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)

Nathan Brashares Sackett

NCT06853912

RECRUITING NA 40 participants

Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms

Walter Reed National Military Medical Center

NCT05414708

RECRUITING Phase 2 40 participants

Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)

VA Office of Research and Development

NCT04452500

RECRUITING Phase 2 40 participants

Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms

Oui Therapeutics

NCT07316088

RECRUITING NA 40 participants

Functional Outcomes of Cannabis Use (FOCUS) in Veterans With Posttraumatic Stress Disorder

VA Office of Research and Development

NCT04565028

RECRUITING NA 40 participants

Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder

Wayne State University

NCT06740487

RECRUITING Phase 3 32 participants

Repurposing Low-Dose Clonidine for PTSD in Veterans

Wake Forest University Health Sciences

NCT04877093

RECRUITING NA 30 participants

Targeting the Default Mode Network: A TMS-fMRI Study

Allyson Rosen

NCT05646732

RECRUITING Phase 4 30 participants

The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

Margaux M. Salas, PhD

NCT06414356

RECRUITING Phase 2 30 participants

MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder

Patricia Suppes

NCT05837845

RECRUITING NA 30 participants

The BEAR Program for Women With Trauma Who Have Suicidal Thoughts

Stanford University

NCT07346638

RECRUITING NA 30 participants

Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI

The University of Texas Health Science Center at San Antonio

NCT07351305

RECRUITING NA 30 participants

Microbiome Modulation With Prebiotics in PTSD and Cirrhosis

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT06464952

RECRUITING NA 30 participants

Breathwork Intervention for Posttraumatic Stress

Florida State University

NCT07129278

RECRUITING Phase 1 24 participants

Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD

Suzanne "Sue" Sisley MD

NCT07275970

RECRUITING NA 24 participants

Cervical Plexus Hydrodissection With D5W for PTSD

Dr. Dean Reeves Clinic

NCT04421573

RECRUITING NA 20 participants

Integrated PTSD and Chronic Pain Treatment

Weill Medical College of Cornell University

NCT07225049

RECRUITING NA 20 participants

Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App

The University of Texas Health Science Center, Houston

NCT06494319

RECRUITING Phase 2 20 participants

Intranasal Insulin for Posttraumatic Stress Disorder

VA Connecticut Healthcare System

NCT04044534

RECRUITING Phase 2 15 participants

State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma

Baylor College of Medicine

NCT06888128

RECRUITING NA 10 participants

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

Massachusetts General Hospital

NCT07260032

ACTIVE NOT RECRUITING NA 720 participants

Building Experience for Treating Trauma and Enhancing Resilience (BETTER)

RAND

NCT05330442

ACTIVE NOT RECRUITING NA 212 participants

Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

Medical University of South Carolina

NCT05384223

ACTIVE NOT RECRUITING NA 141 participants

The Group Risk Reduction Intervention Therapy (GRRIT) Project

University of North Carolina, Charlotte

NCT05401838

ACTIVE NOT RECRUITING NA 140 participants

Exploring Mechanisms of Massed Cognitive Processing Therapy

Rush University Medical Center

NCT05265039

ACTIVE NOT RECRUITING 120 participants

The BEAR Therapeutic Program for Women

Stanford University

NCT04418778

ACTIVE NOT RECRUITING NA 117 participants

PTSD Treatment for Incarcerated Men and Women: WPP

University of Wisconsin, Madison

NCT05432817

ACTIVE NOT RECRUITING NA 87 participants

Non-invasive Nerve Stimulation and Sleep

VA Office of Research and Development

NCT04021537

ACTIVE NOT RECRUITING NA 80 participants

Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy

VA Office of Research and Development

NCT05797441

ACTIVE NOT RECRUITING NA 60 participants

Early Intervention Following Sexual Assault

Medical University of South Carolina

NCT04582695

ACTIVE NOT RECRUITING NA 52 participants

Circadian Influence on Prolonged Exposure Therapy for PTSD

Massachusetts General Hospital

NCT05453162

ACTIVE NOT RECRUITING NA 50 participants

TCI-Massage Clinical Trial

The Center for Victims of Torture, United States

NCT07482358

ACTIVE NOT RECRUITING Phase 1 25 participants

Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder

Yale University

NCT05223829

ACTIVE NOT RECRUITING NA 20 participants

Focused Ultrasound Amygdala Neuromodulation

University of Texas at Austin

NCT05228964

ACTIVE NOT RECRUITING Phase 2 15 participants

Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder

Ohio State University

NCT05554094

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Testing a Transdiagnostic TMS Treatment Target

Brigham and Women's Hospital

NCT06282146

COMPLETED 6,894 participants

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Pregistry

NCT04385238

COMPLETED NA 730 participants

Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)

VA Office of Research and Development

NCT03593772

COMPLETED 338 participants

Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD

Senseye

NCT05717439

COMPLETED Phase 3 304 participants

Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD

VA Office of Research and Development

NCT00532493

COMPLETED NA 206 participants

The Family of Heroes: an Evaluation of an Online Educational Tool

Department of Veterans Affairs, New Jersey

NCT01554839

COMPLETED Phase 2 201 participants

PTSD Prevention Using Oral Hydrocortisone

Rachel Yehuda

NCT04924166

COMPLETED NA 193 participants

Cognitive-Behavior Therapy for Posttraumatic Headache

The University of Texas Health Science Center at San Antonio

NCT02419131

COMPLETED Phase 2 180 participants

Oxytocin to Treat PTSD

VA Office of Research and Development

NCT04228289

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 22
Phase 3 5
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the PTSD Trial Landscape

155 indexed PTSD studies · 77 recruiting (50%).

Phase mix: 10 late (III/IV) vs 29 early (I/II).

Top sponsor: VA Office of Research and Development (28 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for PTSD?

PlainTrial tracks 155 US clinical trials for PTSD, of which 77 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for PTSD?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.