Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
PTSD: early-phase trial registry
77 of 155 indexed PTSD trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #72 of 28,707 conditions by registered trial count.
155 US clinical trials · 77 currently recruiting · #72 of 28,707 conditions by registered trial count
PTSD: 155 US clinical trials tracked, 77 recruiting.
PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.
Enrollment posture brief
Registry condition ptsd
OPEN 77 | RECR 50% | LATE 10 | EARLY 29 | RANK #72 | SPON 28
Volume-matched condition peers
Nearest open-share peer: Alzheimer Disease (50% recruiting · 312 trials)
PTSD lists 77 open slots (50% of 155 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for PTSD on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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PTSD is recruiting above its size-band peers.
77 of 155 indexed trials (49.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates PTSD research.
VA Office of Research and Development accounts for 28 of 155 trials (18.1%). 88 distinct sponsors appear on at least one study for this condition label.
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Typical PTSD enrolment sits around 75 participants.
Median target enrolment is 75 among the 155 trials that report a genuine target (sentinel values excluded). 89 of those (57.4%) plan for fewer than 100 participants.
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PTSD research is mostly interventional.
143 interventional and 12 observational studies make up this index (92.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
155 total, page 2 of 4
Adolescent Stress and Substance Intervention Subsequent to Trauma
Rhode Island Hospital
NCT07197476
Self-Management Interventions After an ICD Shock
University of Washington
NCT06037785
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
NCT06442423
Biomarkers in the Retina for Prognosticating Mental Health Treatments
VA Puget Sound Health Care System
NCT06363968
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Case Western Reserve University
NCT06900712
Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder
Stanford University
NCT06577636
Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
Nathan Brashares Sackett
NCT06853912
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Walter Reed National Military Medical Center
NCT05414708
Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)
VA Office of Research and Development
NCT04452500
Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms
Oui Therapeutics
NCT07316088
Functional Outcomes of Cannabis Use (FOCUS) in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT04565028
Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder
Wayne State University
NCT06740487
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences
NCT04877093
Targeting the Default Mode Network: A TMS-fMRI Study
Allyson Rosen
NCT05646732
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Margaux M. Salas, PhD
NCT06414356
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder
Patricia Suppes
NCT05837845
The BEAR Program for Women With Trauma Who Have Suicidal Thoughts
Stanford University
NCT07346638
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
Microbiome Modulation With Prebiotics in PTSD and Cirrhosis
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06464952
Breathwork Intervention for Posttraumatic Stress
Florida State University
NCT07129278
Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD
Suzanne "Sue" Sisley MD
NCT07275970
Cervical Plexus Hydrodissection With D5W for PTSD
Dr. Dean Reeves Clinic
NCT04421573
Integrated PTSD and Chronic Pain Treatment
Weill Medical College of Cornell University
NCT07225049
Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App
The University of Texas Health Science Center, Houston
NCT06494319
Intranasal Insulin for Posttraumatic Stress Disorder
VA Connecticut Healthcare System
NCT04044534
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma
Baylor College of Medicine
NCT06888128
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
Massachusetts General Hospital
NCT07260032
Building Experience for Treating Trauma and Enhancing Resilience (BETTER)
RAND
NCT05330442
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Medical University of South Carolina
NCT05384223
The Group Risk Reduction Intervention Therapy (GRRIT) Project
University of North Carolina, Charlotte
NCT05401838
Exploring Mechanisms of Massed Cognitive Processing Therapy
Rush University Medical Center
NCT05265039
The BEAR Therapeutic Program for Women
Stanford University
NCT04418778
PTSD Treatment for Incarcerated Men and Women: WPP
University of Wisconsin, Madison
NCT05432817
Non-invasive Nerve Stimulation and Sleep
VA Office of Research and Development
NCT04021537
Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy
VA Office of Research and Development
NCT05797441
Early Intervention Following Sexual Assault
Medical University of South Carolina
NCT04582695
Circadian Influence on Prolonged Exposure Therapy for PTSD
Massachusetts General Hospital
NCT05453162
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder
Yale University
NCT05223829
Focused Ultrasound Amygdala Neuromodulation
University of Texas at Austin
NCT05228964
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
NCT05554094
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
Pregistry
NCT04385238
Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)
VA Office of Research and Development
NCT03593772
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD
Senseye
NCT05717439
Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
VA Office of Research and Development
NCT00532493
The Family of Heroes: an Evaluation of an Online Educational Tool
Department of Veterans Affairs, New Jersey
NCT01554839
PTSD Prevention Using Oral Hydrocortisone
Rachel Yehuda
NCT04924166
Cognitive-Behavior Therapy for Posttraumatic Headache
The University of Texas Health Science Center at San Antonio
NCT02419131
Oxytocin to Treat PTSD
VA Office of Research and Development
NCT04228289
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 22 |
| Phase 3 | 5 |
| Phase 4 | 5 |
Top Sponsors
Named interventions
Most-linked intervention names on PTSD records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on PTSD trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this PTSD page
155 registered trials, 77 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 77 PTSD trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most PTSD trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This PTSD condition card totals 155 registered trials; most-linked intervention Cognitive Processing Therapy; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.