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PTSD clinical trials
77 of 155 indexed PTSD trials are currently recruiting.
155 US clinical trials · 77 currently recruiting
PTSD is the subject of 155 registered US clinical trials on ClinicalTrials.gov, 77 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 29 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 28 of these trials.
The research picture
PTSD has 155 registered US clinical trials, 77 of them open to new participants right now, about 50% of the total.
- 77
- recruiting participants now
- 50%
- of trials open to enrollment
- 10
- in Phase 3–4 (later-stage)
- 28
- top sponsor: VA Office of Research and Development
Active & Recent Trials
155 total, page 2 of 4
Adolescent Stress and Substance Intervention Subsequent to Trauma
Rhode Island Hospital
NCT07197476
Self-Management Interventions After an ICD Shock
University of Washington
NCT06037785
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
NCT06442423
Biomarkers in the Retina for Prognosticating Mental Health Treatments
VA Puget Sound Health Care System
NCT06363968
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Case Western Reserve University
NCT06900712
Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder
Stanford University
NCT06577636
Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
Nathan Brashares Sackett
NCT06853912
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Walter Reed National Military Medical Center
NCT05414708
Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)
VA Office of Research and Development
NCT04452500
Determining the Potential for Efficacy of OTX-601 in Reducing PTSD Symptoms
Oui Therapeutics
NCT07316088
Functional Outcomes of Cannabis Use (FOCUS) in Veterans With Posttraumatic Stress Disorder
VA Office of Research and Development
NCT04565028
Advanced Wireless Augmented Reality-Enhanced Exposure Therapy for Posttraumatic Stress Disorder
Wayne State University
NCT06740487
Repurposing Low-Dose Clonidine for PTSD in Veterans
Wake Forest University Health Sciences
NCT04877093
Targeting the Default Mode Network: A TMS-fMRI Study
Allyson Rosen
NCT05646732
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Margaux M. Salas, PhD
NCT06414356
MDMA-assisted Cognitive Processing Therapy Versus Cognitive Processing Therapy for Veterans With Severe Posttraumatic Stress Disorder
Patricia Suppes
NCT05837845
The BEAR Program for Women With Trauma Who Have Suicidal Thoughts
Stanford University
NCT07346638
Non-Trauma Intervention to Treat PTSD for Veterans and Service Members Suffering From a TBI
The University of Texas Health Science Center at San Antonio
NCT07351305
Microbiome Modulation With Prebiotics in PTSD and Cirrhosis
Hunter Holmes Mcguire Veteran Affairs Medical Center
NCT06464952
Breathwork Intervention for Posttraumatic Stress
Florida State University
NCT07129278
Safety and Preliminary Efficacy of Organic Whole Psilocybin-Containing Mushrooms to Treat Patients Suffering From PTSD
Suzanne "Sue" Sisley MD
NCT07275970
Cervical Plexus Hydrodissection With D5W for PTSD
Dr. Dean Reeves Clinic
NCT04421573
Integrated PTSD and Chronic Pain Treatment
Weill Medical College of Cornell University
NCT07225049
Development Of a Virtual Stress Inoculation Training (SIT) Platform and Mobile Health App
The University of Texas Health Science Center, Houston
NCT06494319
Intranasal Insulin for Posttraumatic Stress Disorder
VA Connecticut Healthcare System
NCT04044534
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma
Baylor College of Medicine
NCT06888128
Determining the Benefits of Exercise on Cardiovascular Risk in PTSD
Massachusetts General Hospital
NCT07260032
Building Experience for Treating Trauma and Enhancing Resilience (BETTER)
RAND
NCT05330442
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Medical University of South Carolina
NCT05384223
The Group Risk Reduction Intervention Therapy (GRRIT) Project
University of North Carolina, Charlotte
NCT05401838
Exploring Mechanisms of Massed Cognitive Processing Therapy
Rush University Medical Center
NCT05265039
The BEAR Therapeutic Program for Women
Stanford University
NCT04418778
PTSD Treatment for Incarcerated Men and Women: WPP
University of Wisconsin, Madison
NCT05432817
Non-invasive Nerve Stimulation and Sleep
VA Office of Research and Development
NCT04021537
Testing the Effectiveness of a Therapist-Assisted Self-Management Program for Veterans Who Finished PTSD Therapy
VA Office of Research and Development
NCT05797441
Early Intervention Following Sexual Assault
Medical University of South Carolina
NCT04582695
Circadian Influence on Prolonged Exposure Therapy for PTSD
Massachusetts General Hospital
NCT05453162
TCI-Massage Clinical Trial
The Center for Victims of Torture, United States
NCT07482358
Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder
Yale University
NCT05223829
Focused Ultrasound Amygdala Neuromodulation
University of Texas at Austin
NCT05228964
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
NCT05554094
Testing a Transdiagnostic TMS Treatment Target
Brigham and Women's Hospital
NCT06282146
Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic
Pregistry
NCT04385238
Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)
VA Office of Research and Development
NCT03593772
Feasibility and ML Training Investigation of the Senseye DT for Diagnosis of Adults with PTSD
Senseye
NCT05717439
Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
VA Office of Research and Development
NCT00532493
The Family of Heroes: an Evaluation of an Online Educational Tool
Department of Veterans Affairs, New Jersey
NCT01554839
PTSD Prevention Using Oral Hydrocortisone
Rachel Yehuda
NCT04924166
Cognitive-Behavior Therapy for Posttraumatic Headache
The University of Texas Health Science Center at San Antonio
NCT02419131
Oxytocin to Treat PTSD
VA Office of Research and Development
NCT04228289
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 7 |
| Phase 2 | 22 |
| Phase 3 | 5 |
| Phase 4 | 5 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the PTSD Trial Landscape
155 indexed PTSD studies · 77 recruiting (50%).
Phase mix: 10 late (III/IV) vs 29 early (I/II).
Top sponsor: VA Office of Research and Development (28 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for PTSD?
PlainTrial tracks 155 US clinical trials for PTSD, of which 77 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for PTSD?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.