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NCT05486793 · ClinicalTrials.gov registry record · NA
Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
A NA study of PTSD, sponsored by Boston University.
- Recruiting
- Registry status
- NA
- Development phase
- 240
- Enrollment target
- 1
- Study location
NCT05486793: Recruiting NA study of PTSD, sponsored by Boston University.
NCT05486793 is a NA study of PTSD that is actively recruiting participants, run by Boston University. The registered enrollment target is 240 participants, below the 300-participant average among 154 other PTSD trials with a reported enrollment target (20% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05486793, a NA study of PTSD, is actively recruiting participants, sponsored by Boston University.
- RECRUITING
- Registry status
- NA
- Development phase
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based treatment for PTSD in usual care obstetrics settings, and patient-level barriers to engagement such as stigma. The proposed study is a randomized controlled trial, which will examine the effectiveness of a brief evidence-based treatment for PTSD (i.e., Written Exposure Therapy) during pregnancy and the non-inferiority of delivery of this treatment by community health workers vs. delivery by mental health clinicians.
Primary Outcome
PTSD symptom severity will be assessed with the Clinician Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders (DSM-5 CAPS-5), a structured diagnostic interview that obtains information about symptom frequency/intensity for all 20 PTSD symptoms using a 5-point scale to obtain a total PTSD severity score. The scale also assesses social and occupational functioning and dissociation symptoms. Scores range from 0-80, with higher scores indicating greater severity.
Conditions Studied
Interventions
- BEHAVIORAL Written Exposure Therapy (WET)
- BEHAVIORAL Emotion Focused Supportive Therapy (EFST)
Study Locations (1)
Massachusetts
- Boston Medical Center and remote - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2023-03-01 |
| Est. Completion | 2027-07-31 |
| Phase | NA |
What NCT05486793 shows while recruiting
NCT05486793 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 300-participant average among 154 other PTSD trials with a reported enrollment target (20% lower).
The record links to 1 condition, with PTSD appearing as the primary indexed condition, and to 2 interventions - of which Written Exposure Therapy (WET) is the first listed.
NCT05486793 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05486793 about?
NCT05486793 is a clinical study titled "Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study". The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based tr...
What is the current status of trial NCT05486793?
This trial is currently recruiting. It is a NA study. The enrollment target is 240 participants. The study started on 2023-03-01. Estimated completion is 2027-07-31.
What conditions does trial NCT05486793 study?
This clinical trial studies the following conditions: PTSD.
What interventions are being tested in trial NCT05486793?
The interventions under investigation include: Written Exposure Therapy (WET) (BEHAVIORAL), Emotion Focused Supportive Therapy (EFST) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05486793?
This trial is sponsored by Boston University, which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05486793 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PTSD
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05486793's enrollment target sits among peer trials
240 23rd of 154 higher than 132 of 154 other PTSD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PTSD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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