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Obstructive Sleep Apnea: early-phase trial registry
66 of 157 indexed Obstructive Sleep Apnea trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #70 of 28,707 conditions by registered trial count.
157 US clinical trials · 66 currently recruiting · #70 of 28,707 conditions by registered trial count
Obstructive Sleep Apnea: 157 US clinical trials tracked, 66 recruiting.
Obstructive Sleep Apnea is the subject of 157 registered US clinical trials on ClinicalTrials.gov, 66 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
Enrollment posture brief
Registry condition obstructive-sleep-apnea
OPEN 66 | RECR 42% | LATE 11 | EARLY 26 | RANK #70 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Anesthesia, Local (42% recruiting · 19 trials)
Obstructive Sleep Apnea lists 66 open slots (42% of 157 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Obstructive Sleep Apnea on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Obstructive Sleep Apnea is recruiting above its size-band peers.
66 of 157 indexed trials (42%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Obstructive Sleep Apnea trials is spread across many organizations.
VA Office of Research and Development accounts for 11 of 157 trials (7%). 96 distinct sponsors appear on at least one study for this condition label.
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Typical Obstructive Sleep Apnea enrolment sits around 76 participants.
Median target enrolment is 76 among the 156 trials that report a genuine target (sentinel values excluded). 85 of those (54.5%) plan for fewer than 100 participants.
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Obstructive Sleep Apnea research is mostly interventional.
123 interventional and 34 observational studies make up this index (78.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
157 total, page 1 of 4
SUNOSI® (Solriamfetol) Pregnancy Registry
Axsome Therapeutics
NCT06413420
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05656365
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
Beth Israel Deaconess Medical Center
NCT04603196
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
VA Office of Research and Development
NCT04179981
Obstructive Sleep Apnea Among Somali-Americans
Mayo Clinic
NCT04124848
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
University of Pennsylvania
NCT06189755
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Seattle Institute for Biomedical and Clinical Research
NCT06390345
OurSleepKit To Support CPAP Adherence
National Heart, Lung, and Blood Institute (NHLBI)
NCT06621511
The Recovery in Stroke Using PAP Study
Yale University
NCT04130503
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
Oregon Health and Science University
NCT05508971
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
NCT05094271
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
Amgen
NCT07226765
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
Amgen
NCT07225686
DISE: Phenotyping Obstruction Patterns
University of Pennsylvania
NCT05050383
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
University of California, San Diego
NCT05237505
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils
Oregon Health and Science University
NCT06258837
Down Syndrome Obstructive Sleep Apnea
Brigham and Women's Hospital
NCT06043440
Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
Ohio State University
NCT05742360
Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
Emory University
NCT05350332
Do Endotypes Predict Response and Sequelae in OSA Patients
University of California, San Diego
NCT04875364
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
California Pacific Medical Center Research Institute
NCT05988385
Predictors of Post-COVID-19 Clinical and Cognitive Consequences
VA Office of Research and Development
NCT06291870
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
Endotypic Traits and Obstructive Sleep Apnea Surgery
University of California, Los Angeles
NCT05953610
Cognition After OSA Treatment Among Native American People (CATNAP)
Washington State University
NCT06227572
OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?
Connecticut Children's Medical Center
NCT05911646
DRonabinol Treatment of OSA
VA Office of Research and Development
NCT06477952
Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics
Children's Hospital Medical Center, Cincinnati
NCT04991389
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
VA Office of Research and Development
NCT02703207
Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation
University of California, San Francisco
NCT07220525
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Vanderbilt University Medical Center
NCT05501236
Metabolism and Sleep Apnea Treatment
University of Miami
NCT05539716
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
Erin Kirkham
NCT05303987
PAP for Children With DS and OSAS
University of Miami
NCT04132999
Time Restricted Eating in Sleep Apnea
University of California, San Diego
NCT06047496
Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea
Slow Wave
NCT06519149
Alesis OSA-1 Obstructive Sleep Apnea Treatment
Photonica USA
NCT06949969
Rescue Pharmacotherapy for OSA
Brigham and Women's Hospital
NCT05293600
Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities
VA Office of Research and Development
NCT05558501
Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea
University of California, San Diego
NCT05804084
Pediatric Post-Approval Registry
Inspire Medical Systems
NCT04457154
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
Tulane University
NCT04814420
Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy
Columbia University
NCT06720545
Bright Light Therapy for OSA
VA Office of Research and Development
NCT05917119
Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives
Washington University School of Medicine
NCT07074288
A Study of Sex Differences in Neurocirculatory Control
Mayo Clinic
NCT06261034
Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
Geisinger Clinic
NCT05618444
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Vanderbilt University Medical Center
NCT05650710
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
Thomas Jefferson University
NCT04191512
Severe Label Expansion for EVO Products Trial
ProSomnus Sleep Technologies
NCT07090395
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 12 |
| Phase 2 | 14 |
| Phase 3 | 8 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Obstructive Sleep Apnea records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Obstructive Sleep Apnea trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Obstructive Sleep Apnea page
157 registered trials, 66 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 66 Obstructive Sleep Apnea trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Obstructive Sleep Apnea trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Obstructive Sleep Apnea condition card totals 157 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.