Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Obstructive Sleep Apnea

Open-data reference.

157 US clinical trials · 66 currently recruiting

Active & Recent Trials

RECRUITING 1,731 participants

SUNOSI® (Solriamfetol) Pregnancy Registry

Axsome Therapeutics

NCT06413420

RECRUITING 1,500 participants

Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05656365

RECRUITING 800 participants

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

Beth Israel Deaconess Medical Center

NCT04603196

RECRUITING NA 668 participants

Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)

VA Office of Research and Development

NCT04179981

RECRUITING 600 participants

Obstructive Sleep Apnea Among Somali-Americans

Mayo Clinic

NCT04124848

RECRUITING 500 participants

MicroRNAs as Biomarkers for Obstructive Sleep Apnea

University of Pennsylvania

NCT06189755

RECRUITING NA 400 participants

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Seattle Institute for Biomedical and Clinical Research

NCT06390345

RECRUITING NA 360 participants

OurSleepKit To Support CPAP Adherence

National Heart, Lung, and Blood Institute (NHLBI)

NCT06621511

RECRUITING NA 360 participants

The Recovery in Stroke Using PAP Study

Yale University

NCT04130503

RECRUITING NA 303 participants

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)

Oregon Health and Science University

NCT05508971

RECRUITING Phase 1 260 participants

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

University of California, San Diego

NCT05094271

RECRUITING Phase 3 250 participants

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

Amgen

NCT07226765

RECRUITING Phase 3 250 participants

Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

Amgen

NCT07225686

RECRUITING NA 241 participants

DISE: Phenotyping Obstruction Patterns

University of Pennsylvania

NCT05050383

RECRUITING Phase 2 240 participants

The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)

University of California, San Diego

NCT05237505

RECRUITING NA 240 participants

Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils

Oregon Health and Science University

NCT06258837

RECRUITING Phase 2 230 participants

Down Syndrome Obstructive Sleep Apnea

Brigham and Women's Hospital

NCT06043440

RECRUITING 227 participants

Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype

Ohio State University

NCT05742360

RECRUITING NA 200 participants

Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy

Emory University

NCT05350332

RECRUITING Phase 2 200 participants

Do Endotypes Predict Response and Sequelae in OSA Patients

University of California, San Diego

NCT04875364

RECRUITING NA 200 participants

The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study

California Pacific Medical Center Research Institute

NCT05988385

RECRUITING 200 participants

Predictors of Post-COVID-19 Clinical and Cognitive Consequences

VA Office of Research and Development

NCT06291870

RECRUITING NA 194 participants

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

VA Office of Research and Development

NCT05156112

RECRUITING Phase 2 150 participants

Endotypic Traits and Obstructive Sleep Apnea Surgery

University of California, Los Angeles

NCT05953610

RECRUITING NA 140 participants

Cognition After OSA Treatment Among Native American People (CATNAP)

Washington State University

NCT06227572

RECRUITING NA 130 participants

OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?

Connecticut Children's Medical Center

NCT05911646

RECRUITING Phase 1 120 participants

DRonabinol Treatment of OSA

VA Office of Research and Development

NCT06477952

RECRUITING Phase 4 120 participants

Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics

Children's Hospital Medical Center, Cincinnati

NCT04991389

RECRUITING NA 108 participants

Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD

VA Office of Research and Development

NCT02703207

RECRUITING NA 100 participants

Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

University of California, San Francis

NCT07220525

RECRUITING NA 100 participants

Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA

Vanderbilt University Medical Center

NCT05501236

RECRUITING NA 100 participants

Metabolism and Sleep Apnea Treatment

University of Miami

NCT05539716

RECRUITING Phase 2 90 participants

Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea

Erin Kirkham

NCT05303987

RECRUITING NA 86 participants

PAP for Children With DS and OSAS

University of Miami

NCT04132999

RECRUITING Early Phase 1 80 participants

Time Restricted Eating in Sleep Apnea

University of California, San Diego

NCT06047496

RECRUITING 70 participants

Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea

Slow Wave

NCT06519149

RECRUITING NA 70 participants

Alesis OSA-1 Obstructive Sleep Apnea Treatment

Photonica USA

NCT06949969

RECRUITING Phase 1 70 participants

Rescue Pharmacotherapy for OSA

Brigham and Women's Hospital

NCT05293600

RECRUITING Phase 1 60 participants

Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities

VA Office of Research and Development

NCT05558501

RECRUITING Phase 2 60 participants

Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea

University of California, San Diego

NCT05804084

RECRUITING 60 participants

Pediatric Post-Approval Registry

Inspire Medical Systems

NCT04457154

RECRUITING NA 60 participants

Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study

Tulane University

NCT04814420

RECRUITING NA 60 participants

Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy

Columbia University

NCT06720545

RECRUITING NA 60 participants

Bright Light Therapy for OSA

VA Office of Research and Development

NCT05917119

RECRUITING NA 60 participants

Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives

Washington University School of Medicine

NCT07074288

RECRUITING 60 participants

A Study of Sex Differences in Neurocirculatory Control

Mayo Clinic

NCT06261034

RECRUITING NA 50 participants

Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA

Geisinger Clinic

NCT05618444

RECRUITING NA 50 participants

Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation

Vanderbilt University Medical Center

NCT05650710

RECRUITING 50 participants

Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.

Thomas Jefferson University

NCT04191512

RECRUITING NA 49 participants

Severe Label Expansion for EVO Products Trial

ProSomnus Sleep Technologies

NCT07090395

RECRUITING NA 48 participants

Community Health Advocates for Motivating PAP Use in Our Neighborhoods.

University of Miami

NCT06047353

RECRUITING NA 40 participants

App-Based Optimization of Long-Term CPAP Adherence and Quality of Life

Mayo Clinic

NCT06381115

RECRUITING NA 40 participants

Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea

Wayne State University

NCT03736382

RECRUITING NA 40 participants

Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia

University of Michigan

NCT05527652

RECRUITING NA 40 participants

Whole Food Plant-based Diet Effect on Obstructive Sleep Apnea

Mayo Clinic

NCT06395181

RECRUITING NA 36 participants

Mandibular Advancement Device and Changes in Nocturia

Fernanda Yanez Regonesi

NCT05562388

RECRUITING Phase 2 36 participants

Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome

University of Arizona

NCT05933603

RECRUITING 30 participants

Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation

University of Chicago

NCT06317701

RECRUITING NA 30 participants

Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement

Washington University School of Medicine

NCT07132307

RECRUITING NA 24 participants

Smart Pillows for Enhancing Sleep Quality

Indiana University

NCT06594627

RECRUITING NA 22 participants

Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness

NYU Langone Health

NCT06698809

RECRUITING NA 20 participants

Preliminary Evaluation of a RCMP to Predict Failure of Maxillomandibular Advancement Surgery for OSA

University of Michigan

NCT03929549

RECRUITING Phase 1 18 participants

Trazodone on OSA Endotypes

Brigham and Women's Hospital

NCT06286189

RECRUITING Phase 1 18 participants

Atomoxetine and DAW2022 on OSA Severity

Brigham and Women's Hospital

NCT05350215

RECRUITING Phase 1 16 participants

Pharmacological Activation of HMN for OSA Aim 2

Brigham and Women's Hospital

NCT03858751

RECRUITING NA 10 participants

Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety

Michael Harrison

NCT02431507

ACTIVE NOT RECRUITING 5,000 participants

A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities

Ulysses Magalang MD

NCT01857427

ACTIVE NOT RECRUITING Phase 3 2,300 participants

A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929066

ACTIVE NOT RECRUITING Phase 3 1,000 participants

A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Eli Lilly and Company

NCT05929079

ACTIVE NOT RECRUITING Phase 2 560 participants

RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA

Incannex Healthcare

NCT06146101

ACTIVE NOT RECRUITING 450 participants

Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy

The Miriam Hospital

NCT02917876

ACTIVE NOT RECRUITING 434 participants

Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation

St. Jude Children's Research Hospital

NCT03361020

ACTIVE NOT RECRUITING 267 participants

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

Yale University

NCT05067088

ACTIVE NOT RECRUITING NA 262 participants

Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)

The Miriam Hospital

NCT02412696

ACTIVE NOT RECRUITING NA 150 participants

Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation

LivaNova

NCT04950894

ACTIVE NOT RECRUITING NA 127 participants

Inspire® Post-Approval Study / Protocol Number 2014-001

Inspire Medical Systems

NCT02413970

ACTIVE NOT RECRUITING NA 122 participants

Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea

University of Arizona

NCT04932447

ACTIVE NOT RECRUITING Phase 2 120 participants

Post-Operative Steroids After Sleep Surgery

Medical University of South Carolina

NCT06818981

ACTIVE NOT RECRUITING NA 115 participants

Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)

Nyxoah S.A.

NCT03868618

ACTIVE NOT RECRUITING NA 81 participants

Validation of Sleep Questionnaires in the Down Syndrome Population

Oregon Health and Science University

NCT03771469

ACTIVE NOT RECRUITING NA 60 participants

Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes

Coastal Carolina University

NCT06525337

ACTIVE NOT RECRUITING Phase 3 57 participants

Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea

Inspire Medical Systems

NCT04801771

ACTIVE NOT RECRUITING 30 participants

RPMO2 Oximeter Accuracy During Sleep 1 Trial

ProSomnus Sleep Technologies

NCT07397780

ACTIVE NOT RECRUITING NA 20 participants

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

University of California, San Francis

NCT05920694

ACTIVE NOT RECRUITING NA 20 participants

3D Printer Modified CPAP Mask for Obstructive Sleep Apnea

Beth Israel Deaconess Medical Center

NCT03932383

ACTIVE NOT RECRUITING NA 14 participants

Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC)

NYU Langone Health

NCT06311045

ACTIVE NOT RECRUITING NA 6 participants

Addressing Sleep Apnea Post-Stroke/TIA

VA Office of Research and Development

NCT04322162

COMPLETED NA 1,873 participants

Impact of Automated Education and Follow-up Mechanisms on Patient Engagement

Kaiser Permanente

NCT02279901

COMPLETED 1,012 participants

World Trade Center (WTC) CHEST

Icahn School of Medicine at Mount Sinai

NCT01466218

COMPLETED NA 744 participants

Asthma and Obstructive Sleep Apnea (OSA)

University of Wisconsin, Madison

NCT01026298

COMPLETED 555 participants

World Trade Center Kidney-Link

Icahn School of Medicine at Mount Sinai

NCT03234530

COMPLETED Phase 3 476 participants

"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"

Jazz Pharmaceuticals

NCT02348606

COMPLETED NA 360 participants

Improving the Frequency and Quality of Sleep Apnea Care Management

VA Office of Research and Development

NCT01916655

COMPLETED NA 317 participants

Obstructive Sleep Apnea in World Trade Center Responders

Rutgers, The State University of New Jersey

NCT01753999

COMPLETED 300 participants

Evaluation of Obstructive Sleep Apnea as a Risk Factor for Pulmonary Embolism

Atlantic Health System

NCT00409045

COMPLETED NA 270 participants

Self-Management of Continuous Positive Airway Pressure Settings

VA Office of Research and Development

NCT03536572

COMPLETED 231 participants

A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)

Children's Hospital Medical Center, Cincinnati

NCT01837459

COMPLETED 217 participants

Patient Perception Questionnaire Validation

Fisher and Paykel Healthcare

NCT02067000

COMPLETED 212 participants

Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes Scale

Boston Children's Hospital

NCT05373979

COMPLETED 200 participants

TipTraQ Home Sleep Test Validation Study, Duke

PranaQ Pte.

NCT06351878

Phase Distribution

PhaseTrial count
Early Phase 1 12
Phase 2 14
Phase 3 8
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Obstructive Sleep Apnea Trial Landscape

ClinicalTrials.gov lists 157 US studies indexed under Obstructive Sleep Apnea, and 66 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Obstructive Sleep Apnea shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Obstructive Sleep Apnea is led by VA Office of Research and Development with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Obstructive Sleep Apnea?

PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Obstructive Sleep Apnea?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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