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Obstructive Sleep Apnea
Open-data reference.
157 US clinical trials · 66 currently recruiting
Active & Recent Trials
SUNOSI® (Solriamfetol) Pregnancy Registry
Axsome Therapeutics
NCT06413420
Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05656365
Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis
Beth Israel Deaconess Medical Center
NCT04603196
Impact of Positive Airway Pressure Therapy on Clinical Outcomes in Older Veterans With Chronic Obstructive Pulmonary Disease and Comorbid Obstructive Sleep Apnea (Overlap Syndrome)
VA Office of Research and Development
NCT04179981
Obstructive Sleep Apnea Among Somali-Americans
Mayo Clinic
NCT04124848
MicroRNAs as Biomarkers for Obstructive Sleep Apnea
University of Pennsylvania
NCT06189755
Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention
Seattle Institute for Biomedical and Clinical Research
NCT06390345
OurSleepKit To Support CPAP Adherence
National Heart, Lung, and Blood Institute (NHLBI)
NCT06621511
The Recovery in Stroke Using PAP Study
Yale University
NCT04130503
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
Oregon Health and Science University
NCT05508971
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
NCT05094271
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
Amgen
NCT07226765
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
Amgen
NCT07225686
DISE: Phenotyping Obstruction Patterns
University of Pennsylvania
NCT05050383
The Cardiovascular Consequences of Sleep Apnea Plus COPD (Overlap Syndrome)
University of California, San Diego
NCT05237505
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils
Oregon Health and Science University
NCT06258837
Down Syndrome Obstructive Sleep Apnea
Brigham and Women's Hospital
NCT06043440
Effect of CPAP on Blood Pressure in Excessively Sleepy Obstructive Sleep Apnea Subtype
Ohio State University
NCT05742360
Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy
Emory University
NCT05350332
Do Endotypes Predict Response and Sequelae in OSA Patients
University of California, San Diego
NCT04875364
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
California Pacific Medical Center Research Institute
NCT05988385
Predictors of Post-COVID-19 Clinical and Cognitive Consequences
VA Office of Research and Development
NCT06291870
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
VA Office of Research and Development
NCT05156112
Endotypic Traits and Obstructive Sleep Apnea Surgery
University of California, Los Angeles
NCT05953610
Cognition After OSA Treatment Among Native American People (CATNAP)
Washington State University
NCT06227572
OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?
Connecticut Children's Medical Center
NCT05911646
DRonabinol Treatment of OSA
VA Office of Research and Development
NCT06477952
Improving Outcomes in Pediatric Obstructive Sleep Apnea With Computational Fluid Dynamics
Children's Hospital Medical Center, Cincinnati
NCT04991389
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD
VA Office of Research and Development
NCT02703207
Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation
University of California, San Francis
NCT07220525
Ansa Cervicalis and Hypoglossal Nerve Stimulation in OSA
Vanderbilt University Medical Center
NCT05501236
Metabolism and Sleep Apnea Treatment
University of Miami
NCT05539716
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
Erin Kirkham
NCT05303987
PAP for Children With DS and OSAS
University of Miami
NCT04132999
Time Restricted Eating in Sleep Apnea
University of California, San Diego
NCT06047496
Safety and Effectiveness of Slow Wave Device for the Treatment of Obstructive Sleep Apnea
Slow Wave
NCT06519149
Alesis OSA-1 Obstructive Sleep Apnea Treatment
Photonica USA
NCT06949969
Rescue Pharmacotherapy for OSA
Brigham and Women's Hospital
NCT05293600
Intermittent Hypoxia-initiated Plasticity in Humans: A Multi-pronged Therapeutic Approach to Treat Sleep Apnea and Overlapping Co-morbidities
VA Office of Research and Development
NCT05558501
Patient-centered and Neurocognitive Outcomes with Acetazolamide for Sleep Apnea
University of California, San Diego
NCT05804084
Pediatric Post-Approval Registry
Inspire Medical Systems
NCT04457154
Atrial Fibrosis in Obstructive Sleep Apnea Patients: A Pilot Study
Tulane University
NCT04814420
Cardiometabolic Risk Effects of Short-term Cessation of Neurostimulation Therapy
Columbia University
NCT06720545
Bright Light Therapy for OSA
VA Office of Research and Development
NCT05917119
Obstructive Sleep Apnea Non-PAP Outcomes and Viable Alternatives
Washington University School of Medicine
NCT07074288
A Study of Sex Differences in Neurocirculatory Control
Mayo Clinic
NCT06261034
Enhancing PAP Adherence Among Spanish-speaking Hispanic Adults With OSA
Geisinger Clinic
NCT05618444
Intraoperative Ansa Cervicalis Nerve (ACN) Stimulation
Vanderbilt University Medical Center
NCT05650710
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
Thomas Jefferson University
NCT04191512
Severe Label Expansion for EVO Products Trial
ProSomnus Sleep Technologies
NCT07090395
Community Health Advocates for Motivating PAP Use in Our Neighborhoods.
University of Miami
NCT06047353
App-Based Optimization of Long-Term CPAP Adherence and Quality of Life
Mayo Clinic
NCT06381115
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
Wayne State University
NCT03736382
Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia
University of Michigan
NCT05527652
Whole Food Plant-based Diet Effect on Obstructive Sleep Apnea
Mayo Clinic
NCT06395181
Mandibular Advancement Device and Changes in Nocturia
Fernanda Yanez Regonesi
NCT05562388
Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome
University of Arizona
NCT05933603
Metabolic Endpoints for Obstructive Sleep Apnea Following Twelfth Cranial Nerve Stimulation
University of Chicago
NCT06317701
Reducing Obstructive Sleep Apnea After Hypoglossal Nerve Stimulation Through Mandibular Advancement
Washington University School of Medicine
NCT07132307
Smart Pillows for Enhancing Sleep Quality
Indiana University
NCT06594627
Obstructive Sleep Apnea Therapeutic Intervention for REsiDual Sleepiness
NYU Langone Health
NCT06698809
Preliminary Evaluation of a RCMP to Predict Failure of Maxillomandibular Advancement Surgery for OSA
University of Michigan
NCT03929549
Trazodone on OSA Endotypes
Brigham and Women's Hospital
NCT06286189
Atomoxetine and DAW2022 on OSA Severity
Brigham and Women's Hospital
NCT05350215
Pharmacological Activation of HMN for OSA Aim 2
Brigham and Women's Hospital
NCT03858751
Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
Michael Harrison
NCT02431507
A Prospective Observational Cohort to Study the Genetics of Obstructive Sleep Apnea and Associated Co-Morbidities
Ulysses Magalang MD
NCT01857427
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929066
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
Eli Lilly and Company
NCT05929079
RePOSA-Revealing the Efficacy of IHL-42X Use in Patients With OSA
Incannex Healthcare
NCT06146101
Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy
The Miriam Hospital
NCT02917876
Obstructive Sleep Apnea in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
St. Jude Children's Research Hospital
NCT03361020
Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness
Yale University
NCT05067088
Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP)
The Miriam Hospital
NCT02412696
Treating Obstructive Sleep Apnea Using Targeted Hypoglossal Neurostimulation
LivaNova
NCT04950894
Inspire® Post-Approval Study / Protocol Number 2014-001
Inspire Medical Systems
NCT02413970
Breathing Training for Improving Cardiovascular Health in Older Adults With Sleep Apnea
University of Arizona
NCT04932447
Post-Operative Steroids After Sleep Surgery
Medical University of South Carolina
NCT06818981
Dual-sided Hypoglossal neRvE stimulAtion for the treatMent of Obstructive Sleep Apnea (DREAM)
Nyxoah S.A.
NCT03868618
Validation of Sleep Questionnaires in the Down Syndrome Population
Oregon Health and Science University
NCT03771469
Adherence to Health Coaching with Wearable Devices: Enhancing Patient Engagement and Outcomes
Coastal Carolina University
NCT06525337
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea
Inspire Medical Systems
NCT04801771
RPMO2 Oximeter Accuracy During Sleep 1 Trial
ProSomnus Sleep Technologies
NCT07397780
Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial
University of California, San Francis
NCT05920694
3D Printer Modified CPAP Mask for Obstructive Sleep Apnea
Beth Israel Deaconess Medical Center
NCT03932383
Obstructive Sleep Apnea (OSA) and Sex-Specific Responses to N-acetylcysteine (NAC)
NYU Langone Health
NCT06311045
Addressing Sleep Apnea Post-Stroke/TIA
VA Office of Research and Development
NCT04322162
Impact of Automated Education and Follow-up Mechanisms on Patient Engagement
Kaiser Permanente
NCT02279901
World Trade Center (WTC) CHEST
Icahn School of Medicine at Mount Sinai
NCT01466218
Asthma and Obstructive Sleep Apnea (OSA)
University of Wisconsin, Madison
NCT01026298
World Trade Center Kidney-Link
Icahn School of Medicine at Mount Sinai
NCT03234530
"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"
Jazz Pharmaceuticals
NCT02348606
Improving the Frequency and Quality of Sleep Apnea Care Management
VA Office of Research and Development
NCT01916655
Obstructive Sleep Apnea in World Trade Center Responders
Rutgers, The State University of New Jersey
NCT01753999
Evaluation of Obstructive Sleep Apnea as a Risk Factor for Pulmonary Embolism
Atlantic Health System
NCT00409045
Self-Management of Continuous Positive Airway Pressure Settings
VA Office of Research and Development
NCT03536572
A Research Study for Children About Heart Changes and Obstructive Sleep Apnea (OSA)
Children's Hospital Medical Center, Cincinnati
NCT01837459
Patient Perception Questionnaire Validation
Fisher and Paykel Healthcare
NCT02067000
Development and Validation of Pediatric Narcolepsy Patient Reported Outcomes Scale
Boston Children's Hospital
NCT05373979
TipTraQ Home Sleep Test Validation Study, Duke
PranaQ Pte.
NCT06351878
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 12 |
| Phase 2 | 14 |
| Phase 3 | 8 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Obstructive Sleep Apnea Trial Landscape
ClinicalTrials.gov lists 157 US studies indexed under Obstructive Sleep Apnea, and 66 of those are currently open to recruitment — roughly 42% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Obstructive Sleep Apnea shows 11 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Obstructive Sleep Apnea is led by VA Office of Research and Development with 11 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 100 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Obstructive Sleep Apnea?
PlainTrial tracks 157 US clinical trials for Obstructive Sleep Apnea, of which 66 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Obstructive Sleep Apnea?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.