Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05789329 · ClinicalTrials.gov registry record · NA
Non-Inferiority Trial of TrIGR for PTSD
A NA study of PTSD, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- NA
- Development phase
- 158
- Enrollment target
- 2
- Study locations
NCT05789329: Recruiting NA study of PTSD, sponsored by VA Office of Research and Development.
NCT05789329 is a NA study of PTSD that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 158 participants, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (48% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05789329, a NA study of PTSD, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- NA
- Development phase
- 158 participants
- Enrollment target
- 2
- Study locations
Study Summary
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical question that this study will seek to answer. 158 Veterans across two VA sites will be randomized to TrIGR or CPT to evaluate changes in PTSD, depression, guilt and shame symptoms across the two treatments.
Primary Outcome
Clinician Administered PTSD Scale - 5 (CAPS-5) - score range 0 - 80; higher scores are indicative of more severe PTSD symptoms. Reduction in scores is considered a positive outcome.
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Processing Therapy
- BEHAVIORAL Trauma Informed Guilt Reduction Therapy
Study Locations (2)
California
- VA San Diego Healthcare System, San Diego, CA - San Diego
Florida
- James A. Haley Veterans' Hospital, Tampa, FL - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 158 participants |
| Start Date | 2023-06-01 |
| Est. Completion | 2027-09-30 |
| Phase | NA |
What NCT05789329 shows while recruiting
NCT05789329 is an interventional study that assigns participants to a tested intervention. The registered 158 participants enrollment target is mid-sized for trials with a published cap, below the 301-participant average among 154 other PTSD trials with a reported enrollment target (48% lower).
The record links to 1 condition, with PTSD appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Processing Therapy is the first listed.
NCT05789329 reports a single indexed study location in California, Florida.
Frequently Asked Questions
What is clinical trial NCT05789329 about?
NCT05789329 is a clinical study titled "Non-Inferiority Trial of TrIGR for PTSD". Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD ...
What is the current status of trial NCT05789329?
This trial is currently recruiting. It is a NA study. The enrollment target is 158 participants. The study started on 2023-06-01. Estimated completion is 2027-09-30.
What conditions does trial NCT05789329 study?
This clinical trial studies the following conditions: PTSD.
What interventions are being tested in trial NCT05789329?
The interventions under investigation include: Cognitive Processing Therapy (BEHAVIORAL), Trauma Informed Guilt Reduction Therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT05789329?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05789329 being conducted?
This trial has 2 study locations across California, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PTSD
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05789329's enrollment target sits among peer trials
158 42nd of 154 higher than 113 of 154 other PTSD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PTSD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Testing an Integrated PTSD and Weight Management Intervention: A Hybrid Type 1 Trial
RECRUITING · NA
-
Treatments for Insomnia in Veterans With PTSD
RECRUITING · NA
-
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
RECRUITING · NA
-
Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building
RECRUITING · NA
-
Project Safe Guard-Trauma
RECRUITING · NA
-
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04486833 · 158 participants · Phase 1
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
- NCT04697966 · 158 participants · NA
Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents
- NCT04969835 · 158 participants · Phase 1
A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours
- NCT05230732 · 158 participants · NA
Neuromodulation of Inflammation and Endothelial Function
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI