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ClinicalTrials.gov 155 recruiting now official registry

Alzheimer Disease clinical trials

155 of 312 indexed Alzheimer Disease trials are currently recruiting.

312 US clinical trials · 155 currently recruiting

Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.

The research picture

Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.

155
recruiting participants now
50%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
13
top sponsor: Eli Lilly and Company
Phase 153Phase 251Phase 318Phase 48

Active & Recent Trials

312 total, page 1 of 7

RECRUITING 200,000 participants

Alzheimer Prevention Trials (APT) Webstudy

University of Southern California

NCT03638583

RECRUITING NA 45,257 participants

Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial

Northwestern University

NCT05607732

RECRUITING 20,000 participants

Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)

Alzheimer's Disease and Related Disorders Association

NCT06170268

RECRUITING 20,000 participants

Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Sanguine Biosciences

NCT05635266

RECRUITING 10,000 participants

Longitudinal Cognitive Assessment by BoCA

Alzheimer's Light

NCT04114994

RECRUITING 10,000 participants

Alzheimer's Disease Genetics Study

Indiana University

NCT00064870

RECRUITING 10,000 participants

NYSCF Scientific Discovery Biobank

New York Stem Cell Foundation Research Institute

NCT06203106

RECRUITING 10,000 participants

Late Onset Alzheimer's Disease

Columbia University

NCT05010603

RECRUITING 6,250 participants

A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease

Eli Lilly and Company

NCT06566170

RECRUITING Phase 3 3,400 participants

Epidemiology and Biomarker Study in Alzheimer's Disease

Eli Lilly and Company

NCT07142954

RECRUITING NA 3,000 participants

Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders

University of Michigan

NCT05929703

RECRUITING NA 2,000 participants

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

Neurobehavioral Systems

NCT04800588

RECRUITING 2,000 participants

Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy

Alzheimer's Light

NCT03657745

RECRUITING NA 1,800 participants

Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers

University of Washington

NCT05596760

RECRUITING 1,800 participants

Study to Understand Novel Biomarkers in Researching Dementia

Washington University School of Medicine

NCT06547099

RECRUITING 1,000 participants

DC Longitudinal Study on Aging and Specimen Bank

Georgetown University

NCT03702907

RECRUITING 1,000 participants

Vanderbilt Memory and Aging Project

Vanderbilt University Medical Center

NCT05372159

RECRUITING 1,000 participants

Tennessee Alzheimer's Project

Vanderbilt University Medical Center

NCT05372172

RECRUITING NA 1,000 participants

Using the EHR to Advance Genomic Medicine Across a Diverse Health System

University of Pennsylvania

NCT06377033

RECRUITING 900 participants

F 18 T807 Tau PET Imaging of Alzheimer's Disease

Tammie L. S. Benzinger, MD, PhD

NCT02414347

RECRUITING 850 participants

Longitudinal Early-onset Alzheimer's Disease Study Protocol

Indiana University

NCT03507257

RECRUITING NA 792 participants

Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)

University of South Florida

NCT06722352

RECRUITING NA 750 participants

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

Hebrew SeniorLife

NCT05950607

RECRUITING 735 participants

Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry

Emory University

NCT05999084

RECRUITING 650 participants

Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)

Tammie L. S. Benzinger, MD, PhD

NCT04579120

RECRUITING Phase 4 614 participants

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

Mayo Clinic

NCT03821857

RECRUITING 600 participants

Triage Survey for Neurology Research Eligibility

Adams Clinical

NCT06104852

RECRUITING Phase 3 600 participants

A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

Bristol-Myers Squibb

NCT06937229

RECRUITING 550 participants

Arizona Alzheimer's Disease Research Center (ADRC)

Banner Health

NCT05405075

RECRUITING NA 515 participants

Implement and Test Visual Consent Template and Process

Washington University School of Medicine

NCT06804837

RECRUITING 500 participants

Cognitive Neurology Unit Clinical Registry

Beth Israel Deaconess Medical Center

NCT05925621

RECRUITING 500 participants

ADRC Clinical Cohort (Alzheimer's Disease)

Duke University

NCT06703541

RECRUITING NA 456 participants

Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase

University of Alabama, Tuscaloo

NCT05820919

RECRUITING 450 participants

Trial-Ready Cohort-Down Syndrome (TRC-DS)

University of Southern California

NCT04165109

RECRUITING NA 440 participants

Evaluating the Efficacy of the Pain Identification and Communication Toolkit

Weill Medical College of Cornell University

NCT06168604

RECRUITING Phase 2 406 participants

A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

Alzheimer's Disease Cooperative Study (ADCS)

NCT06223360

RECRUITING Phase 3 406 participants

A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

Karuna Therapeutics

NCT06585787

RECRUITING NA 388 participants

Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's

Florida State University

NCT05748613

RECRUITING 375 participants

Imaging Biomarkers in Preclinical and Symptomatic AD

Tammie L. S. Benzinger, MD, PhD

NCT04134923

RECRUITING NA 360 participants

Connect-Home: Alzheimer's Disease and Related Dementias

University of North Carolina, Chapel Hill

NCT06840587

RECRUITING Phase 3 352 participants

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)

Bristol-Myers Squibb

NCT07011745

RECRUITING Phase 3 352 participants

A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)

Bristol-Myers Squibb

NCT07011732

RECRUITING Phase 2 300 participants

Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

Lighthouse Pharmaceuticals

NCT06847321

RECRUITING Phase 3 300 participants

Biomarker Exploration in Aging, Cognition and Neurodegeneration

University of California, Irvine

NCT03860857

RECRUITING NA 300 participants

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

Johns Hopkins University

NCT06930560

RECRUITING NA 288 participants

Testing the Effects of a Text Message Caregiver Support Intervention for Latinos

University of Kansas Medical Center

NCT06728436

RECRUITING Phase 2 280 participants

Exercise to Improve Brain Health in Older African Americans

Rutgers, The State University of New Jersey

NCT05597124

RECRUITING Phase 1 260 participants

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

University of California, San Diego

NCT05094271

RECRUITING Phase 2 250 participants

Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease

Columbia University

NCT04840979

RECRUITING 240 participants

Alzheimer"s Imaging Biomarkers in Obesity

Cyrus A Raji

NCT05077579

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Phase Distribution

PhaseTrial count
Phase 1 53
Phase 2 51
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alzheimer Disease Trial Landscape

312 indexed Alzheimer Disease studies · 155 recruiting (50%).

Phase mix: 26 late (III/IV) vs 104 early (I/II).

Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alzheimer Disease?

PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alzheimer Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.