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Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 1 of 7
Alzheimer Prevention Trials (APT) Webstudy
University of Southern California
NCT03638583
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
Alzheimer's National Registry for Treatment and Diagnostics(ALZ-NET)
Alzheimer's Disease and Related Disorders Association
NCT06170268
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Sanguine Biosciences
NCT05635266
Longitudinal Cognitive Assessment by BoCA
Alzheimer's Light
NCT04114994
Alzheimer's Disease Genetics Study
Indiana University
NCT00064870
NYSCF Scientific Discovery Biobank
New York Stem Cell Foundation Research Institute
NCT06203106
Late Onset Alzheimer's Disease
Columbia University
NCT05010603
A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease
Eli Lilly and Company
NCT06566170
Epidemiology and Biomarker Study in Alzheimer's Disease
Eli Lilly and Company
NCT07142954
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
University of Michigan
NCT05929703
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Neurobehavioral Systems
NCT04800588
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
University of Washington
NCT05596760
Study to Understand Novel Biomarkers in Researching Dementia
Washington University School of Medicine
NCT06547099
DC Longitudinal Study on Aging and Specimen Bank
Georgetown University
NCT03702907
Vanderbilt Memory and Aging Project
Vanderbilt University Medical Center
NCT05372159
Tennessee Alzheimer's Project
Vanderbilt University Medical Center
NCT05372172
Using the EHR to Advance Genomic Medicine Across a Diverse Health System
University of Pennsylvania
NCT06377033
F 18 T807 Tau PET Imaging of Alzheimer's Disease
Tammie L. S. Benzinger, MD, PhD
NCT02414347
Longitudinal Early-onset Alzheimer's Disease Study Protocol
Indiana University
NCT03507257
Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)
University of South Florida
NCT06722352
Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0
Hebrew SeniorLife
NCT05950607
Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry
Emory University
NCT05999084
Neuroimaging in Healthy Aging and Senile Dementia (HASD_IND)
Tammie L. S. Benzinger, MD, PhD
NCT04579120
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease
Mayo Clinic
NCT03821857
Triage Survey for Neurology Research Eligibility
Adams Clinical
NCT06104852
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
Bristol-Myers Squibb
NCT06937229
Arizona Alzheimer's Disease Research Center (ADRC)
Banner Health
NCT05405075
Implement and Test Visual Consent Template and Process
Washington University School of Medicine
NCT06804837
Cognitive Neurology Unit Clinical Registry
Beth Israel Deaconess Medical Center
NCT05925621
ADRC Clinical Cohort (Alzheimer's Disease)
Duke University
NCT06703541
Enhancing Sleep Quality for Nursing Home Residents With Dementia - R33 Phase
University of Alabama, Tuscaloo
NCT05820919
Trial-Ready Cohort-Down Syndrome (TRC-DS)
University of Southern California
NCT04165109
Evaluating the Efficacy of the Pain Identification and Communication Toolkit
Weill Medical College of Cornell University
NCT06168604
A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
Alzheimer's Disease Cooperative Study (ADCS)
NCT06223360
A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)
Karuna Therapeutics
NCT06585787
Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's
Florida State University
NCT05748613
Imaging Biomarkers in Preclinical and Symptomatic AD
Tammie L. S. Benzinger, MD, PhD
NCT04134923
Connect-Home: Alzheimer's Disease and Related Dementias
University of North Carolina, Chapel Hill
NCT06840587
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)
Bristol-Myers Squibb
NCT07011745
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)
Bristol-Myers Squibb
NCT07011732
Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease
Lighthouse Pharmaceuticals
NCT06847321
Biomarker Exploration in Aging, Cognition and Neurodegeneration
University of California, Irvine
NCT03860857
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
Johns Hopkins University
NCT06930560
Testing the Effects of a Text Message Caregiver Support Intervention for Latinos
University of Kansas Medical Center
NCT06728436
Exercise to Improve Brain Health in Older African Americans
Rutgers, The State University of New Jersey
NCT05597124
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?
University of California, San Diego
NCT05094271
Discovery and Validation of Genetic Variants Affecting Microglial Activation in Alzheimer's Disease
Columbia University
NCT04840979
Alzheimer"s Imaging Biomarkers in Obesity
Cyrus A Raji
NCT05077579
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.