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NCT05368987 · ClinicalTrials.gov registry record · NA
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
A NA study of PTSD, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- NA
- Development phase
- 250
- Enrollment target
- 1
- Study location
NCT05368987: Recruiting NA study of PTSD, sponsored by The University of Texas Health Science Center, Houston.
NCT05368987 is a NA study of PTSD that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 250 participants, below the 300-participant average among 154 other PTSD trials with a reported enrollment target (17% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05368987, a NA study of PTSD, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
- 1
- Study location
Study Summary
This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to optimize its impact on enhancing fear extinction memory consolidation in a population with known fear extinction deficiencies: post-traumatic stress disorder (PTSD). 250 subjects will take part in this research study across UTHealth Houston. The study will include preliminary screenings, baseline visits, and experimental visits across four days
Primary Outcome
Conductance is measured by placing two electrodes next to the skin and passing a tiny electric charge between the two points. SCR is proportionally related to the number of sweat glands that are activated, meaning in essence that the more emotionally aroused an individual is, the more the SCR amount is increased.
Conditions Studied
Interventions
- DEVICE Transcranial magnetic stimulation (TMS)
- BEHAVIORAL Fear Conditioning and Extinction Paradigm
Study Locations (1)
Texas
- UTHealth Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2022-02-01 |
| Est. Completion | 2027-09-30 |
| Phase | NA |
What NCT05368987 shows while recruiting
NCT05368987 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 300-participant average among 154 other PTSD trials with a reported enrollment target (17% lower).
The record links to 1 condition, with PTSD appearing as the primary indexed condition, and to 2 interventions - of which Transcranial magnetic stimulation (TMS) is the first listed.
NCT05368987 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05368987 about?
NCT05368987 is a clinical study titled "Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans". This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to optimize its impact on enhancing fear extinction memory consolidation in a...
What is the current status of trial NCT05368987?
This trial is currently recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2022-02-01. Estimated completion is 2027-09-30.
What conditions does trial NCT05368987 study?
This clinical trial studies the following conditions: PTSD.
What interventions are being tested in trial NCT05368987?
The interventions under investigation include: Transcranial magnetic stimulation (TMS) (DEVICE), Fear Conditioning and Extinction Paradigm (BEHAVIORAL).
Who is sponsoring clinical trial NCT05368987?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05368987 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for PTSD
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05368987's enrollment target sits among peer trials
250 20th of 154 higher than 134 of 154 other PTSD trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other PTSD trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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