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NCT00108992 · ClinicalTrials.gov registry record · Phase 3

Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis

A Phase 3 study of Osteoarthritis, Knee, sponsored by Nuvo Research.

Completed
Registry status
Phase 3
Development phase
750
Enrollment target
20
Study locations

NCT00108992 is a Phase 3 study of Osteoarthritis, Knee that has completed, run by Nuvo Research. The registered enrollment target is 750 participants, above the 572-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (31% higher). The trial reports 20 study locations across 12 states.

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The verdict

NCT00108992, a Phase 3 study of Osteoarthritis, Knee, has completed, sponsored by Nuvo Research.

COMPLETED
Registry status
Phase 3
Development phase
750 participants
Enrollment target
20
Study locations

Study Summary

Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may relieve pain and other symptoms of osteoarthritis of the knee, while minimizing the side effects common to oral NSAIDs. The purpose of this study is to determine the safety and effectiveness of a topical NSAID when used alone or when combined with an oral NSAID in the treatment of osteoarthritis of the knee.

Conditions Studied

Osteoarthritis, Knee

Interventions

  • DRUG Diclofenac, topical

Study Locations (20)

California

  • OMC Clinical - Beverly Hills
  • Associated Pharmaceutical Research - Buena Park
  • Med Investigators - Fair Oaks
  • Desert Medical Advances - Palm Desert
  • Boling Clinical Trials - Upland

Pennsylvania

  • Camp Hill Clinical Research Center - Camp Hill
  • Primary Physicians Research - Pittsburgh
  • University Orthopedics Center - State College

Florida

  • Tampa Bay Medical Research Inc. - Clearwater
  • Palm Beach Research Center - West Palm Beach

Texas

  • Research Across America - Dallas
  • Sam Clinical Research Center - San Antonio

Alabama

  • Coastal Clinical Research - Mobile

Arizona

  • Redpoint Research - Phoenix

Indiana

  • Medisphere Medical Research - Evansville

Michigan

  • Synergy Medical Education Alliance - Saginaw

Trial Details

FieldValue
Enrollment Target 750 participants
Start Date 2004-02
Est. Completion 2005-09
Phase Phase 3

Sponsor

Nuvo Research

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00108992

The ClinicalTrials.gov registry entry for NCT00108992 describes a study currently listed as completed, categorized as Phase 3. The registered enrollment target is 750 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 572-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (31% higher). The listed sponsor is Nuvo Research, which has 1 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Diclofenac, topical is the first listed.

NCT00108992 reports 20 study locations spanning 12 distinct geographic areas - top geographies include California, Pennsylvania, Florida.

Frequently Asked Questions

What is clinical trial NCT00108992 about?

NCT00108992 is a clinical study titled "Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis". Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may ...

What is the current status of trial NCT00108992?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 750 participants. The study started on 2004-02. Estimated completion is 2005-09.

What conditions does trial NCT00108992 study?

This clinical trial studies the following conditions: Osteoarthritis, Knee.

What interventions are being tested in trial NCT00108992?

The interventions under investigation include: Diclofenac, topical (DRUG).

Who is sponsoring clinical trial NCT00108992?

This trial is sponsored by Nuvo Research, which has 1 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00108992 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.