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NCT00108992 · ClinicalTrials.gov registry record · Phase 3
Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis
A Phase 3 study of Osteoarthritis, Knee, sponsored by Nuvo Research.
- Completed
- Registry status
- Phase 3
- Development phase
- 750
- Enrollment target
- 20
- Study locations
NCT00108992: Completed Phase 3 study of Osteoarthritis, Knee, sponsored by Nuvo Research.
NCT00108992 is a Phase 3 study of Osteoarthritis, Knee that has completed, run by Nuvo Research. The registered enrollment target is 750 participants, above the 491-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (53% higher). The trial reports 20 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00108992, a Phase 3 study of Osteoarthritis, Knee, has completed, sponsored by Nuvo Research.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 750 participants
- Enrollment target
- 20
- Study locations
Study Summary
Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may relieve pain and other symptoms of osteoarthritis of the knee, while minimizing the side effects common to oral NSAIDs. The purpose of this study is to determine the safety and effectiveness of a topical NSAID when used alone or when combined with an oral NSAID in the treatment of osteoarthritis of the knee.
Conditions Studied
Interventions
- DRUG Diclofenac, topical
Study Locations (20)
California
- OMC Clinical - Beverly Hills
- Associated Pharmaceutical Research - Buena Park
- Med Investigators - Fair Oaks
- Desert Medical Advances - Palm Desert
- Boling Clinical Trials - Upland
Pennsylvania
- Camp Hill Clinical Research Center - Camp Hill
- Primary Physicians Research - Pittsburgh
- University Orthopedics Center - State College
Florida
- Tampa Bay Medical Research Inc. - Clearwater
- Palm Beach Research Center - West Palm Beach
Texas
- Research Across America - Dallas
- Sam Clinical Research Center - San Antonio
Alabama
- Coastal Clinical Research - Mobile
Arizona
- Redpoint Research - Phoenix
Indiana
- Medisphere Medical Research - Evansville
Michigan
- Synergy Medical Education Alliance - Saginaw
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 750 participants |
| Start Date | 2004-02 |
| Est. Completion | 2005-09 |
| Phase | Phase 3 |
What the finished NCT00108992 record still lists
NCT00108992 is an interventional study that assigns participants to a tested intervention. The registered 750 participants enrollment target is mid-sized for trials with a published cap, above the 491-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (53% higher).
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which Diclofenac, topical is the first listed.
NCT00108992 names 20 study sites across 12 states, led by California, Pennsylvania, Florida.
Frequently Asked Questions
What is clinical trial NCT00108992 about?
NCT00108992 is a clinical study titled "Efficacy and Safety of Topical Diclofenac Combined With Oral Diclofenac in the Treatment of Knee Osteoarthritis". Oral non-steroidal anti-inflammatory drugs (NSAIDs) are a recommended treatment for the symptoms of osteoarthritis of the knee. However, NSAIDs may cause a range of negative side effects, including stomach pain, heartburn, bleeding stomach ulcer, and liver or kidney abnormality. A topical NSAID may ...
What is the current status of trial NCT00108992?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 750 participants. The study started on 2004-02. Estimated completion is 2005-09.
What conditions does trial NCT00108992 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT00108992?
The interventions under investigation include: Diclofenac, topical (DRUG).
Who is sponsoring clinical trial NCT00108992?
This trial is sponsored by Nuvo Research, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00108992 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00108992's enrollment target sits among peer trials
750 15th of 112 higher than 98 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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