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NCT04815902 · ClinicalTrials.gov registry record · Phase 1
Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis
A Phase 1 study of Osteoarthritis, Knee, sponsored by Steadman Philippon Research Institute.
- Active
- Registry status
- Phase 1
- Development phase
- 100
- Enrollment target
- 1
- Study location
NCT04815902 is a Phase 1 study of Osteoarthritis, Knee that is active but no longer recruiting, run by Steadman Philippon Research Institute. The registered enrollment target is 100 participants, below the 579-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04815902, a Phase 1 study of Osteoarthritis, Knee, is active but no longer recruiting, sponsored by Steadman Philippon Research Institute.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 100 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective, randomized, double-blind, active control clinical trial to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently and in combination, to improve beneficial effect demonstrated by the active control which is to be injection of autologous bone marrow aspirate concentrate (BMAC) into an osteoarthritic knee.
Conditions Studied
Interventions
- DRUG Fisetin
- DRUG Losartan
- DRUG Placebo - Losartan
- DRUG Placebo Fisetin
Study Locations (1)
Colorado
- The Steadman Clinic - Vail
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2021-05-18 |
| Est. Completion | 2025-06-01 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04815902
The ClinicalTrials.gov registry entry for NCT04815902 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 579-participant average among 91 other Osteoarthritis, Knee trials with a reported enrollment target (83% lower). The listed sponsor is Steadman Philippon Research Institute, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 4 interventions - of which Fisetin is the first listed.
NCT04815902 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT04815902 about?
NCT04815902 is a clinical study titled "Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis". This is a prospective, randomized, double-blind, active control clinical trial to evaluate the safety and efficacy of a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently and in combination, to improve beneficial effect demonstrated by the active control which is to ...
What is the current status of trial NCT04815902?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 100 participants. The study started on 2021-05-18. Estimated completion is 2025-06-01.
What conditions does trial NCT04815902 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT04815902?
The interventions under investigation include: Fisetin (DRUG), Losartan (DRUG), Placebo - Losartan (DRUG), Placebo Fisetin (DRUG).
Who is sponsoring clinical trial NCT04815902?
This trial is sponsored by Steadman Philippon Research Institute, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04815902 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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