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NCT03660943 · ClinicalTrials.gov registry record · Phase 3
A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain
A Phase 3 study of Osteoarthritis, Knee, sponsored by Centrexion Therapeutics.
- Completed
- Registry status
- Phase 3
- Development phase
- 332
- Enrollment target
- 20
- Study locations
NCT03660943: Completed Phase 3 study of Osteoarthritis, Knee, sponsored by Centrexion Therapeutics.
NCT03660943 is a Phase 3 study of Osteoarthritis, Knee that has completed, run by Centrexion Therapeutics. The registered enrollment target is 332 participants, below the 495-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (33% lower). The trial reports 20 study locations across 9 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03660943, a Phase 3 study of Osteoarthritis, Knee, has completed, sponsored by Centrexion Therapeutics.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 332 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects with chronic, moderate-to-severe osteoarthritis knee pain.
Primary Outcome
The Western Ontario and McMaster Universities developed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score to use among patients with knee and/or hip OA. The WOMAC is a validated, multidimensional measure of pain, stiffness, and physical functional disability that is sensitive to the effects of drugs or other interventions. This study used the 11-box NPRS format ranging from 0 (none or no pain/stiffness/difficulty) to 10 (extreme). The WOMAC is a self-administered index
Conditions Studied
Interventions
- DRUG Placebo
- DRUG CNTX-4975-05
Study Locations (20)
Florida
- Panamerican Health Center, Inc. - Miami
- Well Pharma Medical Research, Corp - Miami
- Quality Research & Medical Center LLC - Miami
- San Marcus Research Clinic, Inc. - Miami Lakes
- Journey Research, Inc. - Oldsmar
- M&M Clinical Trials Sunrise - Sunrise
- Conquest Research - Winter Park
Arizona
- Holland Center for Family Health - Glendale
- GB Family Care - Phoenix
- Arizona Research Center - Phoenix
California
- Med Center Medical Clinic - Carmichael
- TriWest Research Associates - El Cajon
- Arthritis Care and Research Center, Inc. (ACRC Studies) - Poway
Illinois
- Healthcare Research Network, LLC - Flossmoor
- Affinity Clinical Research Institute - Oak Brook
Connecticut
- Chase Medical Research, LLC - Waterbury
Georgia
- Better Health Clinical Research, Inc. - Newnan
Louisiana
- DelRicht Research - New Orleans
Maryland
- The Center for Rheumatology and Bone Research - Wheaton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 332 participants |
| Start Date | 2018-09-09 |
| Est. Completion | 2020-06-11 |
| Phase | Phase 3 |
What the finished NCT03660943 record still lists
NCT03660943 is an interventional study that assigns participants to a tested intervention. The registered 332 participants enrollment target is mid-sized for trials with a published cap, below the 495-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (33% lower).
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT03660943 names 20 study sites across 9 states, led by Florida, Arizona, California.
Frequently Asked Questions
What is clinical trial NCT03660943 about?
NCT03660943 is a clinical study titled "A Clinical Study to Test Efficacy and Safety of Repeat Doses of CNTX-4975-05 in Patients With Osteoarthritis Knee Pain". This is a randomized, double-blind, placebo-controlled, 2-injection, 52-week study to evaluate the efficacy and safety of intra-articular injections of CNTX-4975-05 in subjects with chronic, moderate-to-severe osteoarthritis knee pain.
What is the current status of trial NCT03660943?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 332 participants. The study started on 2018-09-09. Estimated completion is 2020-06-11.
What conditions does trial NCT03660943 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT03660943?
The interventions under investigation include: Placebo (DRUG), CNTX-4975-05 (DRUG).
Who is sponsoring clinical trial NCT03660943?
This trial is sponsored by Centrexion Therapeutics, which has 12 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03660943 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03660943's enrollment target sits among peer trials
332 25th of 112 higher than 88 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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