Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03529942 · ClinicalTrials.gov registry record · Phase 3
Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee
A Phase 3 study of Osteoarthritis, Knee, sponsored by Pacira Pharmaceuticals.
- Completed
- Registry status
- Phase 3
- Development phase
- 129
- Enrollment target
- 10
- Study locations
NCT03529942: Completed Phase 3 study of Osteoarthritis, Knee, sponsored by Pacira Pharmaceuticals.
NCT03529942 is a Phase 3 study of Osteoarthritis, Knee that has completed, run by Pacira Pharmaceuticals. The registered enrollment target is 129 participants, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (74% lower). The trial reports 10 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03529942, a Phase 3 study of Osteoarthritis, Knee, has completed, sponsored by Pacira Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 129 participants
- Enrollment target
- 10
- Study locations
Study Summary
This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
Primary Outcome
Synovial volume (mm\^3) as measured by MRI and read by a central imaging vendor. Standardization was performed by dividing the model-derived least squares means and corresponding confidence intervals by the adjusted standard deviation (SD). Therefore, the mean standardized change represents the change in synovial volume expressed in standard deviation units.
Conditions Studied
Interventions
- DRUG FX006 32 mg
Study Locations (10)
California
- TriWest Research Associates, LLC - El Cajon
- Biosolutions Research - La Mesa
- Dream Team Clinical Research (formerly located in Anaheim) - Pomona
- Dream Team Clinical Research - Pomona
Florida
- Tampa Bay Medical Research, Inc. - Clearwater
Illinois
- Rush University Medical Center - Chicago
North Carolina
- Duke University Medical Center - Durham
Pennsylvania
- Altoona Center for Clinical Research - Duncansville
Tennessee
- PMG Research, Inc. d/b/a PMG Research of Knoxville - Knoxville
Other
- University of Leeds - Leeds
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 129 participants |
| Start Date | 2018-04-24 |
| Est. Completion | 2020-03-09 |
| Phase | Phase 3 |
What the finished NCT03529942 record still lists
NCT03529942 is an interventional study that assigns participants to a tested intervention. The registered 129 participants enrollment target is mid-sized for trials with a published cap, below the 497-participant average among 112 other Osteoarthritis, Knee trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Osteoarthritis, Knee appearing as the primary indexed condition, and to 1 intervention - of which FX006 32 mg is the first listed.
NCT03529942 lists 10 locations in 7 states (California, Florida, Illinois).
Frequently Asked Questions
What is clinical trial NCT03529942 about?
NCT03529942 is a clinical study titled "Study to Evaluate the Effect of FX006 on Synovial Inflammation in Patients With OA of the Knee". This is an open-label study assessing the effect of the administration of a single intra-articular (IA) injection of FX006 32 mg on synovial volume in patients with osteoarthritis (OA) of the knee.
What is the current status of trial NCT03529942?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 129 participants. The study started on 2018-04-24. Estimated completion is 2020-03-09.
What conditions does trial NCT03529942 study?
This clinical trial studies the following conditions: Osteoarthritis, Knee.
What interventions are being tested in trial NCT03529942?
The interventions under investigation include: FX006 32 mg (DRUG).
Who is sponsoring clinical trial NCT03529942?
This trial is sponsored by Pacira Pharmaceuticals, which has 88 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03529942 being conducted?
This trial has 10 study locations across California, Florida, Illinois, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Osteoarthritis, Knee
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03529942's enrollment target sits among peer trials
129 53rd of 112 higher than 60 of 112 other Osteoarthritis, Knee trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Osteoarthritis, Knee trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
RECRUITING · Phase 3
-
Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans
RECRUITING · Phase 3
-
A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
ACTIVE NOT RECRUITING · Phase 3
-
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
ACTIVE NOT RECRUITING · Phase 3
-
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
ACTIVE NOT RECRUITING · Phase 3
-
Microfragmented Adipose Tissue Compared to Saline Injection for the Treatment of Knee Osteoarthritis
ACTIVE NOT RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03619850 · 129 participants · Phase 3
A Study to Evaluate the Safety (Compared to Iron Sucrose), Efficacy and Pharmacokinetics of Ferumoxytol for the Treatment of Iron Deficiency Anemia (IDA) in Pediatric Subjects With Chronic Kidney Disease (CKD)
- NCT05704361 · 129 participants · Phase 1
A Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO7121932 Administration in Participants With Multiple Sclerosis
- NCT05919849 · 129 participants · Phase 1
Supporting Parents in Affirming Their Children's Experiences of Stigma
- NCT06313749 · 129 participants · NA
Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI