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Osteoarthritis, Knee: full-pipeline trial registry
45 of 115 indexed Osteoarthritis, Knee trials are currently recruiting.
Corpus placement: #110 of 28,707 conditions by registered trial count.
115 US clinical trials · 45 currently recruiting · #110 of 28,707 conditions by registered trial count
Osteoarthritis, Knee: 115 US clinical trials tracked, 45 recruiting.
Osteoarthritis, Knee is the subject of 115 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 23 are in Phase 3-4 (later-stage) and 34 in Phase 1-2 (earlier-stage). The most active sponsor is Regeneron Pharmaceuticals, running 4 of these trials.
Enrollment posture brief
Registry condition osteoarthritis-knee
OPEN 45 | RECR 39% | LATE 23 | EARLY 34 | RANK #110 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Advanced Non-Small-Cell Lung Cancer (39% recruiting · 23 trials)
Osteoarthritis, Knee lists 45 open slots (39% of 115 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Osteoarthritis, Knee on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Osteoarthritis, Knee is recruiting above its size-band peers.
45 of 115 indexed trials (39.1%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Osteoarthritis, Knee trials is spread across many organizations.
Regeneron Pharmaceuticals accounts for 4 of 115 trials (3.5%). 90 distinct sponsors appear on at least one study for this condition label.
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Typical Osteoarthritis, Knee enrolment sits around 120 participants.
Median target enrolment is 120 among the 113 trials that report a genuine target (sentinel values excluded). 44 of those (38.9%) plan for fewer than 100 participants.
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Osteoarthritis, Knee research is mostly interventional.
104 interventional and 11 observational studies make up this index (90.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
115 total, page 3 of 3
OA Clinic-Community CARE Model
University of North Carolina, Chapel Hill
NCT05349500
Gait Modifications and Cutaneous Stimulation
Stanford University
NCT02884414
A Study of the Construct Validity of Community Walking Speed Data Collected Remotely With the Canary canturioTM te Tibial Extension
Canary Medical
NCT05539326
Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty
The University of Tennessee, Knoxville
NCT04103515
Prehabilitation Using Aquatic Exercise
Wake Forest University Health Sciences
NCT02773745
Effect of Zilretta Injection
University of North Carolina, Chapel Hill
NCT04261049
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
ZetrOZ
NCT04391842
Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Xalud Therapeutics
NCT03477487
Self Cranial Electrical Stimulation (CES) for Pain in Older Adults With Knee Osteoarthritis (Self CES for Knee Pain)
The University of Texas Health Science Center, Houston
NCT04016259
Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
Duke University
NCT03395990
Study to Evaluate the Safety and Efficacy of a Low Level Light Device in Patients With Knee Osteoarthritis
Light Sciences
NCT00375544
Radiofrequency For Chronic Knee Pain Post-Arthroplasty
Randall Brewer, MD, CPI
NCT02931435
Study of a Steroid Delivery System for Pain Relief Treatment in Patients With Knee Osteoarthritis
Mark Figgie
NCT02873273
Cost-Effectiveness of and Long-Term Outcomes Following Acupuncture Treatment for Osteoarthritis of the Knee
National Center for Complementary and Integrative Health (NCCIH)
NCT00010647
Comparison of Hylastan to Methylprednisolone Acetate in Patients With Symptomatic Osteoarthritis of the Knee
Genzyme, a Sanofi Company
NCT00139295
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 17 |
| Phase 2 | 17 |
| Phase 3 | 14 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Osteoarthritis, Knee records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Osteoarthritis, Knee trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Osteoarthritis, Knee page
115 registered trials, 45 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 45 Osteoarthritis, Knee trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Regeneron Pharmaceuticals sponsors the most Osteoarthritis, Knee trials on record, review their full trial history before evaluating a specific study. See Regeneron Pharmaceuticals's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Osteoarthritis, Knee condition card totals 115 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.