Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Long COVID: early-phase trial registry
32 of 51 indexed Long COVID trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #274 of 28,707 conditions by registered trial count.
51 US clinical trials · 32 currently recruiting · #274 of 28,707 conditions by registered trial count
Long COVID: 51 US clinical trials tracked, 32 recruiting.
Long COVID is the subject of 51 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 5 of these trials.
Enrollment posture brief
Registry condition long-covid
OPEN 32 | RECR 63% | LATE 2 | EARLY 21 | RANK #274 | SPON 5
Volume-matched condition peers
Nearest open-share peer: Caregiver Burden (63% recruiting · 43 trials)
Long COVID lists 32 open slots (63% of 51 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Long COVID on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Long COVID is recruiting above its size-band peers.
32 of 51 indexed trials (62.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Long COVID trials is spread across many organizations.
Duke University accounts for 5 of 51 trials (9.8%). 35 distinct sponsors appear on at least one study for this condition label.
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Typical Long COVID enrolment sits around 90 participants.
Median target enrolment is 90 among the 51 trials that report a genuine target (sentinel values excluded). 27 of those (52.9%) plan for fewer than 100 participants.
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Long COVID research is mostly interventional.
47 interventional and 4 observational studies make up this index (92.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
51 total, page 1 of 2
The Long COVID-19 Wearable Device Study
Scripps Translational Science Institute
NCT05741112
COVID-19 Outcome Prediction Algorithm
University of California, Los Angeles
NCT05471011
Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID
Wes Ely
NCT06631287
Long-Covid-19 Alleviation Through Learning Mindfulness Study
Columbia University
NCT07140094
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
Douglas D. Fraser
NCT06928272
Long-term COVID and Rehabilitation
VA Office of Research and Development
NCT05373043
Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19
MaxWell Clinic
NCT06311435
NE3107 in Adults With Neurological Symptoms of Long COVID
BioVie
NCT06847191
Immune-mediated Pathogenic Mechanisms of Neuro-PASC in Veterans
VA Office of Research and Development
NCT06932237
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT for Long COVID)
Medical University of South Carolina
NCT05855369
Mind Body Intervention for Long COVID-19
Beth Israel Deaconess Medical Center
NCT06045338
LIFT: Life Improvement Trial
Brigham and Women's Hospital
NCT06366724
Long COVID Immune Profiling
Vanderbilt University Medical Center
NCT06027255
AT1001 for the Treatment of Long COVID
Massachusetts General Hospital
NCT05747534
Lumbrokinase for Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Icahn School of Medicine at Mount Sinai
NCT06511050
Heat thErapy And mobiLity in COVID-19 Survivors
University of Nebraska
NCT06928116
Antiviral Clinical Trial for Long Covid-19
Icahn School of Medicine at Mount Sinai
NCT06511063
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation
University of New Mexi
NCT06940609
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
Vanderbilt University Medical Center
NCT05421208
PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)
National Institute of Mental Health (NIMH)
NCT06920628
Improving Attention in Individuals With Long COVID-19
Shirley Ryan AbilityLab
NCT06503874
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
Stanford University
NCT05833217
Water-based Activity to Enhance Recovery in Long COVID-19
VA Office of Research and Development
NCT06142253
tVNS in Long COVID-19
Icahn School of Medicine at Mount Sinai
NCT06585254
Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog
Mayo Clinic
NCT06614309
A Study to Examine Anktiva for the Treatment of COVID-19.
ImmunityBio
NCT07123727
Long COVID Brain Fog: Cognitive Rehabilitation Trial
University of Alabama at Birmingham
NCT06095297
Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues
University of Chicago
NCT06171152
Sauna for Long Covid
Massachusetts General Hospital
NCT05931497
CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19
University of California, San Francisco
NCT05530317
Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID
University of Louisville
NCT06883513
Acupuncture and Chinese Herbal Medicine for Long COVID
Southern California University of Health Sciences
NCT07285707
The Long COVID Treatment Trial
Scripps Translational Science Institute
NCT07128082
RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
Duke University
NCT06404112
RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)
Duke University
NCT06404099
RECOVER-ENERGIZE Platform Protocol_Appendix A (Exercise Intolerance)
Duke University
NCT06404060
RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)
Kanecia Obie Zimmerman
NCT06305793
Assessing the Efficacy of Sirolimus in Patients With COVID-19 Pneumonia for Prevention of Post-COVID Fibrosis
University of Chicago
NCT04948203
Pain in Long COVID-19: the Role of Sleep
Beth Israel Deaconess Medical Center
NCT05606211
Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID
Timothy Henrich
NCT06161688
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)
Michael Peluso, MD
NCT05877508
Fatigability in Long COVID-19
VA Office of Research and Development
NCT05699538
RECOVER-SLEEP: Platform Protocol
Duke University
NCT06404086
RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms
Duke University
NCT05965739
CZI Rare As One: Co-designing an App and Wearable Based Compass for Rare Diseases
4YouandMe
NCT06907953
Fluvoxamine for Long COVID-19
Washington University School of Medicine
NCT05874037
Valacyclovir Plus Celecoxib for Post-Acute Sequelae of SARS-CoV-2
Bateman Horne Center
NCT06316843
Qigong for Post Acute Sequelae of COVID-19 Infection
University of California, Davis
NCT05675995
Effect of Daily Walnut Consumption on Memory in Subjects With Long-COVID
University of California, Los Angeles
NCT07429903
Nitrite Supplementation in Long COVID Patients
VA Office of Research and Development
NCT05618574
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 18 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Long COVID records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Long COVID trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Long COVID page
51 registered trials, 32 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 32 Long COVID trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Duke University sponsors the most Long COVID trials on record, review their full trial history before evaluating a specific study. See Duke University's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Long COVID condition card totals 51 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.