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NCT05877508 · ClinicalTrials.gov registry record · Phase 2
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)
A Phase 2 study of Long COVID and Post-Acute COVID-19, sponsored by Michael Peluso, MD.
- Active
- Registry status
- Phase 2
- Development phase
- 36
- Enrollment target
- 1
- Study location
NCT05877508: Active Phase 2 study of Long COVID and Post-Acute COVID-19, sponsored by Michael Peluso, MD.
NCT05877508 is a Phase 2 study of Long COVID and Post-Acute COVID-19 that is active but no longer recruiting, run by Michael Peluso, MD. The registered enrollment target is 36 participants, below the 2,187-participant average among 50 other Long COVID trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05877508, a Phase 2 study of Long COVID and Post-Acute COVID-19, is active but no longer recruiting, sponsored by Michael Peluso, MD.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be able to be targeted by SARS-CoV-2 monoclonal antibodies (mAbs). This trial will study the safety and efficacy of AER002 to treat individuals with Long COVID in an adult population.
Primary Outcome
This measure will evaluate whether there is a difference between treatment with AER002 versus placebo in baseline adjusted mean PROMIS-29 Physical Health Summary Score at Day 90 post-infusion. PROMIS-29 is a validated scale assessing physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social activities, and pain. Each domain is scored on a 5-point scale (without any difficulty, with a little difficulty, with some difficulty, with much difficulty, unable
Conditions Studied
Interventions
- OTHER Placebo
- DRUG AER002
Study Locations (1)
California
- UCSF/Zuckerberg San Francisco General Hospital - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2023-08-01 |
| Est. Completion | 2026-07-31 |
| Phase | Phase 2 |
What the registry record for NCT05877508 still lists
NCT05877508 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 2,187-participant average among 50 other Long COVID trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Long COVID appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05877508 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05877508 about?
NCT05877508 is a clinical study titled "Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)". Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be able to be targeted by SARS-CoV-2 monoclonal antibodies (mAbs). This trial will study the safety and...
What is the current status of trial NCT05877508?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 36 participants. The study started on 2023-08-01. Estimated completion is 2026-07-31.
What conditions does trial NCT05877508 study?
This clinical trial studies the following conditions: Long COVID, Post-Acute COVID-19, Post-Acute Sequela of COVID-19.
What interventions are being tested in trial NCT05877508?
The interventions under investigation include: Placebo (OTHER), AER002 (DRUG).
Who is sponsoring clinical trial NCT05877508?
This trial is sponsored by Michael Peluso, MD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05877508 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Long COVID
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05877508's enrollment target sits among peer trials
36 41st of 50 higher than 10 of 50 other Long COVID trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Long COVID trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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A Study to Examine Anktiva for the Treatment of COVID-19.
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