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Acute Pain
Open-data reference.
51 US clinical trials · 13 currently recruiting
Active & Recent Trials
The Implementation of a Post-operative Communication App to Improve Pain Control and Opioid Use
University of Minnesota
NCT06124079
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
Brigham and Women's Hospital
NCT06466941
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
Florida State University
NCT07335159
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
University of California, Davis
NCT04166877
Characterization of Acute Pain
Children's National Research Institute
NCT07336264
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Florida State University
NCT06471075
Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection
University of California, San Diego
NCT04849455
COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children
Duke University
NCT06164028
Twin Block, Pain Medications and Third Molar Extractions
Rutgers, The State University of New Jersey
NCT04880707
Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises
University of Maryland, Baltimore
NCT06184126
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
Reducing Pain From Wisdom Molar Extractions
Rutgers, The State University of New Jersey
NCT05335070
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
KK Women's and Children's Hospital
NCT03408717
The Effect of Light Therapy on Post-Surgical Pain
University of Arizona
NCT03674697
Evaluation of the Analgesic Efficacy of Multimodal Pain Control Regimens That Aim to Limit the Use of Narcotics in Cholecystectomy and Hernia Repairs
Methodist Health System
NCT06095453
Vasopressin and Pain Perception in the Brain
University of Maryland, Baltimore
NCT03446456
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
Duke University
NCT05966129
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy
Trevena
NCT02815709
Clinical Trial Comparing Two Protocols Using Intravenous (IV) Hydromorphone
Montefiore Medical Center
NCT01311895
Efficacy and Safety of Oxymorphone Immediate Release in Post-surgical Acute Pain
Endo Pharmaceuticals
NCT00226395
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Vertex Pharmaceuticals Incorporated
NCT05034952
Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain
Montefiore Medical Center
NCT00305110
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Vertex Pharmaceuticals Incorporated
NCT04977336
A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomy
Tris Pharma
NCT06423703
Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain
Cerimon Pharmaceuticals
NCT00869180
Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion
Cerimon Pharmaceuticals
NCT00869063
Efficacy of XP20B Following Bunionectomy Surgery
Xanodyne Pharmaceuticals
NCT00655291
Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED
Montefiore Medical Center
NCT03521102
Examination of Psychological and Physiological Pathways Linking Gratitude and Pain
Black Hills State University
NCT06317844
Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain
iX Biopharma
NCT03246971
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Washington University School of Medicine
NCT02926573
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University
NCT03859635
Pharmacogenetic-guided Choice of Post-surgery Analgesics
University of Pennsylvania
NCT05548660
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures
AltheaDx
NCT02605343
Efficacy of Gabapentin vs. Placebo for Adjuvant Pain Control Following Acute Rib Fractures
Denver Health and Hospital Authority
NCT02856750
Auricular Acupuncture for Acute Pain
Samueli Institute for Information Biology
NCT00253994
Liposome Bupivacaine Interscalene Total Shoulder
University of Minnesota
NCT03587636
Comparison of Epidural and TAP Block in Abdominal Surgery
University of Nebraska
NCT01848951
NSS-2 BRIDGE Device in Post-Operative Pain Management
Jacques E. Chelly
NCT03555266
A Brief Intervention for Patients on Opioids for Acute Pain
Henry Ford Health System
NCT05658926
A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery
Cara Therapeutics
NCT01789476
A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
Sparian Biosciences
NCT05721287
VR for Burn Dressing Changes at Home
Nationwide Children's Hospital
NCT04548635
The Use of Ultrasound to Measure Depth of Thoracic Epidural Space
University of Massachusetts, Worcester
NCT01172730
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
East Carolina University
NCT03571737
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
University of California, San Francis
NCT04301895
The Influence of Testosterone on Experimental Pain Perception
University of New Mexi
NCT05781685
Assessment of PF614 Effects on Experimental Pain in the Cold Pressure Test (PF614-201)
Ensysce Biosciences
NCT06629402
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 5 |
| Phase 2 | 12 |
| Phase 3 | 10 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Acute Pain Trial Landscape
ClinicalTrials.gov lists 51 US studies indexed under Acute Pain, and 13 of those are currently open to recruitment — roughly 25% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Acute Pain shows 13 late-stage studies (Phase 3 and Phase 4 combined) alongside 17 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Acute Pain is led by Montefiore Medical Center with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 51 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Acute Pain?
PlainTrial tracks 51 US clinical trials for Acute Pain, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Acute Pain?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.