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Acute Pain: full-pipeline trial registry
13 of 51 indexed Acute Pain trials are currently recruiting.
Corpus placement: #274 of 28,707 conditions by registered trial count.
51 US clinical trials · 13 currently recruiting · #274 of 28,707 conditions by registered trial count
Acute Pain: 51 US clinical trials tracked, 13 recruiting.
Acute Pain is the subject of 51 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 17 in Phase 1-2 (earlier-stage). The most active sponsor is Montefiore Medical Center, running 3 of these trials.
Enrollment posture brief
Registry condition acute-pain
OPEN 13 | RECR 25% | LATE 13 | EARLY 17 | RANK #274 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Tobacco Use Disorder (25% recruiting · 75 trials)
Acute Pain lists 13 open slots (25% of 51 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Acute Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Acute Pain is recruiting below its size-band peers.
13 of 51 indexed trials (25.5%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Acute Pain trials is spread across many organizations.
Montefiore Medical Center accounts for 3 of 51 trials (5.9%). 42 distinct sponsors appear on at least one study for this condition label.
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Typical Acute Pain enrolment sits around 110 participants.
Median target enrolment is 110 among the 51 trials that report a genuine target (sentinel values excluded). 22 of those (43.1%) plan for fewer than 100 participants.
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Acute Pain research is mostly interventional.
42 interventional and 9 observational studies make up this index (82.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
51 total, page 1 of 2
The Implementation of a Post-operative Communication App to Improve Pain Control and Opioid Use
University of Minnesota
NCT06124079
Understanding the Acute Pain Phenotype in Patients Undergoing Surgery
Brigham and Women's Hospital
NCT06466941
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
Brown University
NCT05754190
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
Florida State University
NCT07335159
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
University of California, Davis
NCT04166877
Characterization of Acute Pain
Children's National Research Institute
NCT07336264
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Florida State University
NCT06471075
Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection
University of California, San Diego
NCT04849455
COA-APTIC Cognitive Interview Study of Caregiver and Clinician Assessment of Acute Pain in Infants and Young Children
Duke University
NCT06164028
Twin Block, Pain Medications and Third Molar Extractions
Rutgers, The State University of New Jersey
NCT04880707
Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises
University of Maryland, Baltimore
NCT06184126
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
Reducing Pain From Wisdom Molar Extractions
Rutgers, The State University of New Jersey
NCT05335070
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
KK Women's and Children's Hospital
NCT03408717
The Effect of Light Therapy on Post-Surgical Pain
University of Arizona
NCT03674697
Evaluation of the Analgesic Efficacy of Multimodal Pain Control Regimens That Aim to Limit the Use of Narcotics in Cholecystectomy and Hernia Repairs
Methodist Health System
NCT06095453
Vasopressin and Pain Perception in the Brain
University of Maryland, Baltimore
NCT03446456
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Acute Pain Trial)
Duke University
NCT05966129
Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Herniorrhaphy
Viatris Specialty
NCT06215859
Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Bunionectomy
Trevena
NCT02815709
Clinical Trial Comparing Two Protocols Using Intravenous (IV) Hydromorphone
Montefiore Medical Center
NCT01311895
Efficacy and Safety of Oxymorphone Immediate Release in Post-surgical Acute Pain
Endo Pharmaceuticals
NCT00226395
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Vertex Pharmaceuticals Incorporated
NCT05034952
Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain
Montefiore Medical Center
NCT00305110
A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Vertex Pharmaceuticals Incorporated
NCT04977336
A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomy
Tris Pharma
NCT06423703
Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain
Cerimon Pharmaceuticals
NCT00869180
Diclofenac Patch for the Treatment of Acute Pain Due to Mild to Moderate Wrist Sprain, Strain or Contusion
Cerimon Pharmaceuticals
NCT00869063
Efficacy of XP20B Following Bunionectomy Surgery
Xanodyne Pharmaceuticals
NCT00655291
Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED
Montefiore Medical Center
NCT03521102
Examination of Psychological and Physiological Pathways Linking Gratitude and Pain
Black Hills State University
NCT06317844
Study of Wafermine™ for Post-bunionectomy or Abdominoplasty Pain
iX Biopharma
NCT03246971
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Washington University School of Medicine
NCT02926573
Erector Spinae Block Versus Surgeon Infiltration in VATS Procedures
Indiana University
NCT03859635
Pharmacogenetic-guided Choice of Post-surgery Analgesics
University of Pennsylvania
NCT05548660
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
Mylan Specialty
NCT05317312
Prospective Observational Clinical Study to Evaluate Patient Outcomes Following Pharmacogenetic Testing of Patients Undergoing Elective Surgical Procedures
AltheaDx
NCT02605343
Efficacy of Gabapentin vs. Placebo for Adjuvant Pain Control Following Acute Rib Fractures
Denver Health and Hospital Authority
NCT02856750
Auricular Acupuncture for Acute Pain
Samueli Institute for Information Biology
NCT00253994
Liposome Bupivacaine Interscalene Total Shoulder
University of Minnesota
NCT03587636
Comparison of Epidural and TAP Block in Abdominal Surgery
University of Nebraska
NCT01848951
NSS-2 BRIDGE Device in Post-Operative Pain Management
Jacques E. Chelly
NCT03555266
A Brief Intervention for Patients on Opioids for Acute Pain
Henry Ford Health System
NCT05658926
A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery
Cara Therapeutics
NCT01789476
A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
Sparian Biosciences
NCT05721287
VR for Burn Dressing Changes at Home
Nationwide Children's Hospital
NCT04548635
The Use of Ultrasound to Measure Depth of Thoracic Epidural Space
University of Massachusetts, Worcester
NCT01172730
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
East Carolina University
NCT03571737
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
University of California, San Francisco
NCT04301895
The Influence of Testosterone on Experimental Pain Perception
University of New Mexi
NCT05781685
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 5 |
| Phase 2 | 12 |
| Phase 3 | 10 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Acute Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Acute Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Acute Pain page
51 registered trials, 13 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 13 Acute Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Montefiore Medical Center sponsors the most Acute Pain trials on record, review their full trial history before evaluating a specific study. See Montefiore Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Acute Pain condition card totals 51 registered trials; most-linked intervention Placebo; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.