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Peripheral Artery Disease
Open-data reference.
51 US clinical trials · 28 currently recruiting
Active & Recent Trials
Vascular Lab Resource (VLR) Biorepository
The Cleveland Clinic
NCT05628948
Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy
Brigham and Women's Hospital
NCT06300450
Improving Mobility After Revascularization in Peripheral Artery Disease
Northwestern University
NCT06686121
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
Mercator MedSystems
NCT04433572
Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease
Northwestern University
NCT03871075
Telehealth Delivered Home-based Walking for Vets With Peripheral Artery Disease
VA Office of Research and Development
NCT06033924
Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss
Northwestern University
NCT04228978
BEETroot Juice to Reverse Functional Impairment in PAD
Northwestern University
NCT05624125
Response to Exercise and Nitric Oxide in PAD
Northwestern University
NCT06657976
Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease
Nationwide Children's Hospital
NCT03622359
The COCOA-PAD II Trial
Northwestern University
NCT04794530
PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG
Aventusoft
NCT06567795
The THOR IDE Study
Philips Clinical & Medical Affairs Global
NCT05916950
The Effects of Diet and Exercise Interventions in Peripheral Artery Disease
University of Oklahoma
NCT03845036
Leg Heat Therapy in Peripheral Artery Disease
Indiana University
NCT05465070
The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease
University of Oklahoma
NCT05712395
Exercise Therapy for PAD Using Mobile Health
VA Office of Research and Development
NCT04889105
Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation
VA Office of Research and Development
NCT03995238
Red Light Treatment in Peripheral Artery Disease
University of Alabama at Birmingham
NCT03203239
Far Red Light to Improve Functioning in PAD
Northwestern University
NCT06165016
ENhancing Exercise with LIGHT to Improve Functioning in PAD
Northwestern University
NCT06399900
Community-based Exercise Following Revascularization for PAD
University of Minnesota
NCT04252950
Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease
University of Pennsylvania
NCT06212271
Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease
University of Nebraska
NCT06389149
Passive Calf Stretching Therapy in Peripheral Artery Disease
Penn State University
NCT06041880
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
University of Nebraska
NCT06319339
Oxygen-guided Supervised Exercise Therapy
VA Office of Research and Development
NCT06003855
The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication
Louis Messina
NCT04800692
Disrupt PAD BTK II Study With the Shockwave Peripheral IVL System
Shockwave Medical
NCT05007925
Improve PAD PERformance With METformin
Northwestern University
NCT03054519
Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD
VA Office of Research and Development
NCT05048979
Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2
Profusa
NCT04514861
RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty
Boston Scientific Corporation
NCT03064126
Low InTensity Exercise Intervention in PAD
Northwestern University
NCT02538900
Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System
Cordis US
NCT01355406
BARD® Study of LIFESTREAM™ Balloon Expandable Covered Stent Treating Iliac Arterial Occlusive Disease
C. R. Bard
NCT02228564
Absolute Pro® MOMENTUM™
Abbott Medical Devices
NCT01444378
Implementation of Telemedicine for Patient With Lower Extremity Wounds
University of California, Davis
NCT04440839
Dysvascular Amputation Self-Management of Health
University of Colorado, Denver
NCT04083456
Imaging-Guided Vessel Sizing in the Tibial Arteries
University Hospitals Cleveland Medical Center
NCT04748965
A Cross-Sectional Study to Assess Walking Performance in Subjects With Peripheral Artery and End Stage Kidney Disease
Sanifit Therapeutics S. A.
NCT04487301
Exercise for Women With Peripheral Arterial Disease
University of Oklahoma
NCT01241747
Optical Imaging Measurement of Intravascular Solution Efficacy Trial
University Hospitals Cleveland Medical Center
NCT01743872
Using Smartphone Sensor Technology to Characterize Ambulatory Patterns of Participants With Peripheral Artery Disease
University of Minnesota
NCT04124315
Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure
Thomas Jefferson University
NCT01499134
Humacyte's HAV for Femoro-Popliteal Bypass in Patients With PAD
Humacyte
NCT02887859
Pilot Study of PRT-201 Following Angioplasty in Patients With Peripheral Artery Disease (PAD)
Proteon Therapeutics
NCT01616290
Dietary Nitrate Supplementation and Thermoregulation
University of Nebraska
NCT03506646
Assessment Of Vascular Health After Niacin Therapy (AVANT)
University of Pennsylvania
NCT02003638
NAD Supplementation and Vascular Health in PAD
University of Oklahoma
NCT06534944
Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)
Michael Murphy
NCT02863926
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 6 |
| Phase 2 | 3 |
| Phase 3 | 6 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Peripheral Artery Disease Trial Landscape
ClinicalTrials.gov lists 51 US studies indexed under Peripheral Artery Disease, and 28 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Peripheral Artery Disease shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Peripheral Artery Disease is led by Northwestern University with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 51 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Peripheral Artery Disease?
PlainTrial tracks 51 US clinical trials for Peripheral Artery Disease, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Peripheral Artery Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.