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2026 data Public-data reference. official source

Peripheral Artery Disease

Open-data reference.

51 US clinical trials · 28 currently recruiting

Active & Recent Trials

RECRUITING 500 participants

Vascular Lab Resource (VLR) Biorepository

The Cleveland Clinic

NCT05628948

RECRUITING NA 400 participants

Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

Brigham and Women's Hospital

NCT06300450

RECRUITING Phase 3 386 participants

Improving Mobility After Revascularization in Peripheral Artery Disease

Northwestern University

NCT06686121

RECRUITING Phase 3 250 participants

Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee

Mercator MedSystems

NCT04433572

RECRUITING NA 230 participants

Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease

Northwestern University

NCT03871075

RECRUITING NA 225 participants

Telehealth Delivered Home-based Walking for Vets With Peripheral Artery Disease

VA Office of Research and Development

NCT06033924

RECRUITING NA 212 participants

Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

Northwestern University

NCT04228978

RECRUITING NA 210 participants

BEETroot Juice to Reverse Functional Impairment in PAD

Northwestern University

NCT05624125

RECRUITING Phase 2 200 participants

Response to Exercise and Nitric Oxide in PAD

Northwestern University

NCT06657976

RECRUITING NA 192 participants

Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Nationwide Children's Hospital

NCT03622359

RECRUITING Phase 3 190 participants

The COCOA-PAD II Trial

Northwestern University

NCT04794530

RECRUITING 189 participants

PRimary IndividualiZed Evaluation of Cardiovascular Events in Patients With Diabetes Mellitus Using hemoTAG

Aventusoft

NCT06567795

RECRUITING NA 155 participants

The THOR IDE Study

Philips Clinical & Medical Affairs Global

NCT05916950

RECRUITING NA 150 participants

The Effects of Diet and Exercise Interventions in Peripheral Artery Disease

University of Oklahoma

NCT03845036

RECRUITING NA 106 participants

Leg Heat Therapy in Peripheral Artery Disease

Indiana University

NCT05465070

RECRUITING NA 100 participants

The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease

University of Oklahoma

NCT05712395

RECRUITING NA 75 participants

Exercise Therapy for PAD Using Mobile Health

VA Office of Research and Development

NCT04889105

RECRUITING NA 54 participants

Optimizing Gait Rehabilitation for Veterans With Non-traumatic Lower Limb Amputation

VA Office of Research and Development

NCT03995238

RECRUITING NA 40 participants

Red Light Treatment in Peripheral Artery Disease

University of Alabama at Birmingham

NCT03203239

RECRUITING NA 32 participants

Far Red Light to Improve Functioning in PAD

Northwestern University

NCT06165016

RECRUITING NA 32 participants

ENhancing Exercise with LIGHT to Improve Functioning in PAD

Northwestern University

NCT06399900

RECRUITING NA 30 participants

Community-based Exercise Following Revascularization for PAD

University of Minnesota

NCT04252950

RECRUITING Early Phase 1 24 participants

Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease

University of Pennsylvania

NCT06212271

RECRUITING NA 24 participants

Leg Exercise Assistive Paddling (LEAP) Therapy for Peripheral Artery Disease

University of Nebraska

NCT06389149

RECRUITING NA 24 participants

Passive Calf Stretching Therapy in Peripheral Artery Disease

Penn State University

NCT06041880

RECRUITING Early Phase 1 20 participants

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

University of Nebraska

NCT06319339

RECRUITING NA 12 participants

Oxygen-guided Supervised Exercise Therapy

VA Office of Research and Development

NCT06003855

RECRUITING Phase 1 10 participants

The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication

Louis Messina

NCT04800692

ACTIVE NOT RECRUITING NA 250 participants

Disrupt PAD BTK II Study With the Shockwave Peripheral IVL System

Shockwave Medical

NCT05007925

ACTIVE NOT RECRUITING Phase 3 203 participants

Improve PAD PERformance With METformin

Northwestern University

NCT03054519

ACTIVE NOT RECRUITING NA 73 participants

Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD

VA Office of Research and Development

NCT05048979

ACTIVE NOT RECRUITING NA 53 participants

Monitoring Local Tissue Oxygen Changes Using the Wireless Lumee Oxygen Platform in Correlation to TcPO2

Profusa

NCT04514861

COMPLETED Phase 3 440 participants

RANGER™ Paclitaxel Coated Balloon vs Standard Balloon Angioplasty

Boston Scientific Corporation

NCT03064126

COMPLETED NA 305 participants

Low InTensity Exercise Intervention in PAD

Northwestern University

NCT02538900

COMPLETED NA 257 participants

Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System

Cordis US

NCT01355406

COMPLETED NA 155 participants

BARD® Study of LIFESTREAM™ Balloon Expandable Covered Stent Treating Iliac Arterial Occlusive Disease

C. R. Bard

NCT02228564

COMPLETED NA 141 participants

Absolute Pro® MOMENTUM™

Abbott Medical Devices

NCT01444378

COMPLETED NA 116 participants

Implementation of Telemedicine for Patient With Lower Extremity Wounds

University of California, Davis

NCT04440839

COMPLETED Phase 2 40 participants

Dysvascular Amputation Self-Management of Health

University of Colorado, Denver

NCT04083456

COMPLETED 40 participants

Imaging-Guided Vessel Sizing in the Tibial Arteries

University Hospitals Cleveland Medical Center

NCT04748965

COMPLETED 36 participants

A Cross-Sectional Study to Assess Walking Performance in Subjects With Peripheral Artery and End Stage Kidney Disease

Sanifit Therapeutics S. A.

NCT04487301

COMPLETED NA 33 participants

Exercise for Women With Peripheral Arterial Disease

University of Oklahoma

NCT01241747

COMPLETED NA 23 participants

Optical Imaging Measurement of Intravascular Solution Efficacy Trial

University Hospitals Cleveland Medical Center

NCT01743872

COMPLETED 19 participants

Using Smartphone Sensor Technology to Characterize Ambulatory Patterns of Participants With Peripheral Artery Disease

University of Minnesota

NCT04124315

COMPLETED Phase 3 17 participants

Comparison of 2 Beta Blocker Drugs on Peripheral Arterial Disease in Patients With High Blood Pressure

Thomas Jefferson University

NCT01499134

COMPLETED Phase 2 15 participants

Humacyte's HAV for Femoro-Popliteal Bypass in Patients With PAD

Humacyte

NCT02887859

COMPLETED Phase 1 14 participants

Pilot Study of PRT-201 Following Angioplasty in Patients With Peripheral Artery Disease (PAD)

Proteon Therapeutics

NCT01616290

COMPLETED NA 11 participants

Dietary Nitrate Supplementation and Thermoregulation

University of Nebraska

NCT03506646

COMPLETED NA 9 participants

Assessment Of Vascular Health After Niacin Therapy (AVANT)

University of Pennsylvania

NCT02003638

COMPLETED Phase 1 8 participants

NAD Supplementation and Vascular Health in PAD

University of Oklahoma

NCT06534944

COMPLETED Phase 1 6 participants

Use of Autologous Concentrated Bone Marrow Aspirate in Preventing Wound Complications in Below Knee Amputation (BKA)

Michael Murphy

NCT02863926

Phase Distribution

PhaseTrial count
Early Phase 1 6
Phase 2 3
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Peripheral Artery Disease Trial Landscape

ClinicalTrials.gov lists 51 US studies indexed under Peripheral Artery Disease, and 28 of those are currently open to recruitment — roughly 55% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Peripheral Artery Disease shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Peripheral Artery Disease is led by Northwestern University with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 51 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Peripheral Artery Disease?

PlainTrial tracks 51 US clinical trials for Peripheral Artery Disease, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Peripheral Artery Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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