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2026 data Public-data reference. official source

Congestive Heart Failure

Open-data reference.

52 US clinical trials · 8 currently recruiting

Active & Recent Trials

RECRUITING NA 798 participants

Care Transitions App for Patients With Multiple Chronic Conditions

Brigham and Women's Hospital

NCT06051058

RECRUITING 550 participants

Circulating Markers for Ischemic Heart Disease

UConn Health

NCT00762333

RECRUITING NA 388 participants

Pharmacy-led Transitions of Care Intervention to Improve Medication Adherence

University of Tennessee

NCT06374277

RECRUITING 300 participants

Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease

University of Utah

NCT01099982

RECRUITING 200 participants

TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

Mayo Clinic

NCT05507879

RECRUITING NA 112 participants

Stress and Congestive Heart Failure

Yale University

NCT04551560

RECRUITING Phase 1 57 participants

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

Sardocor

NCT04703842

RECRUITING 20 participants

Palliative Care for People With HF

Indiana University

NCT07356843

ACTIVE NOT RECRUITING NA 1,686 participants

SyncAV Post-Market Trial

Abbott Medical Devices

NCT04100148

ACTIVE NOT RECRUITING NA 1,080 participants

Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)

University of California, Los Angeles

NCT06526884

ACTIVE NOT RECRUITING 400 participants

Plasma ExtrAcellular RNAs and Biomarkers of Heart FaiLure During Decongestion: PEARL-HF Study

Massachusetts General Hospital

NCT02632656

ACTIVE NOT RECRUITING 302 participants

Prediction of ARrhythmic Events With Positron Emission Tomography II

State University of New York at Buffalo

NCT03493516

ACTIVE NOT RECRUITING Phase 2 150 participants

Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure

AskBio

NCT05598333

ACTIVE NOT RECRUITING Phase 1 17 participants

AB-1002 in Patients With Class III Heart Failure

AskBio

NCT04179643

COMPLETED NA 1,915 participants

Improving Patient Prioritization During Hospital-homecare Transition

Columbia University

NCT04136951

COMPLETED NA 1,820 participants

MADIT-CRT: Multicenter Automatic Defibrillator Implantation With Cardiac Resynchronization Therapy

Boston Scientific Corporation

NCT00180271

COMPLETED NA 1,660 participants

Tele-HF: Yale Heart Failure Telemonitoring Study

Yale University

NCT00303212

COMPLETED 1,214 participants

CardioMEMS HF System Post Approval Study

Abbott Medical Devices

NCT02279888

COMPLETED 450 participants

PROSPECT: Predictors of Response to Cardiac Re-Synchronization Therapy

Medtronic Cardiac Rhythm and Heart Failure

NCT00253357

COMPLETED Phase 2 360 participants

Device Evaluation of Contak Renewal 2and Easytrak 2 - DECREASE-HF

Boston Scientific Corporation

NCT00158951

COMPLETED NA 316 participants

Aetna_Intel Medicare Home Biomonitoring Study

Aetna

NCT01105572

COMPLETED Phase 2 305 participants

At-Home Automated External Defibrillator (AED) Training Study

Public Health - Seattle and King County

NCT00219674

COMPLETED Phase 1 290 participants

Empowering Elders Through Technology

Robert Wood Johnson Foundation

NCT00261664

COMPLETED NA 287 participants

Evaluating a Low-Literacy Discharge Medication Education Tool

University of California, Los Angeles

NCT00408733

COMPLETED NA 251 participants

Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral

Johns Hopkins University

NCT05574699

COMPLETED Phase 2 204 participants

Safety and Efficacy Study of Once and Twice Daily Doses of MCC-135 in Subjects With Congestive Heart Failure.

Takeda

NCT00050076

COMPLETED NA 200 participants

Does Detailed Informed Consent for Cardiopulmonary Resuscitation and Mechanical Ventilation Impact Patients' Decisions and Outcomes?

Jewish Hospital, Cincinnati, Ohio

NCT01878968

COMPLETED NA 195 participants

Insomnia Self-Management in Heart Failure

Yale University

NCT02660385

COMPLETED Phase 3 150 participants

DILIPO (DILutIonal HyPOnatremia)

Sanofi

NCT00274326

COMPLETED NA 139 participants

Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA

Peter Lindenauer, MD

NCT05562037

COMPLETED NA 124 participants

Health Literacy in Patients With Congestive Heart Failure

Griffin Hospital

NCT00508716

COMPLETED NA 105 participants

Leveraging Home Health Aides to Improve Outcomes in Heart Failure

Weill Medical College of Cornell University

NCT04239911

COMPLETED NA 97 participants

Specialized Community Disease Management to Reduce Substance Use and Hospital Readmissions

Treatment Research Institute

NCT02059005

COMPLETED Phase 3 75 participants

Study to Evaluate the Safety of Twice Daily Oral Carvedilol

Shaddy, Robert, M.D.

NCT00129363

COMPLETED NA 66 participants

Congestive Heart Failure Weight Study

Central DuPage Hospital

NCT01185249

COMPLETED NA 60 participants

Mind-body Interventions in Cardiac Patients

Massachusetts General Hospital

NCT01270568

COMPLETED 52 participants

Utility of Serial BNP Levels in Emergency Department CHF

Ohio State University

NCT00534066

COMPLETED Phase 2 50 participants

Rosiglitazone to Treat Patients With Heart Failure and Glucose Intolerance or Type II Diabetes

National Heart, Lung, and Blood Institute (NHLBI)

NCT00064727

COMPLETED 47 participants

Evaluation of the EasySense System in Congestive Heart Failure

Ohio State University

NCT03237923

COMPLETED NA 43 participants

Heart Failure Patient Self-Management Web Portal Pilot Study

University of Michigan

NCT01009151

COMPLETED 42 participants

Advanced Wireless, Wearable Sensors for Continuous Hemodynamic Monitoring

Northwestern University

NCT04362553

COMPLETED NA 41 participants

His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy

University of Chicago

NCT02700425

COMPLETED Phase 1 33 participants

Cardiac Stem Cell Infusion in Patients With Ischemic CardiOmyopathy (SCIPIO)

University of Louisville

NCT00474461

COMPLETED NA 31 participants

Daxor - Blood Volume Analysis

Duke University

NCT04111185

COMPLETED Phase 3 30 participants

Inhaled Beta-adrenergic Agonists to Treat Pulmonary Vascular Disease in Heart Failure With Preserved EF (BEAT HFpEF): A Randomized Controlled Trial

Mayo Clinic

NCT02885636

COMPLETED NA 30 participants

Study of Coronary Artery Disease by Two Types of Angiography

VA Connecticut Healthcare System

NCT00273819

COMPLETED NA 30 participants

Researching Emotions And Cardiac Health

Massachusetts General Hospital

NCT02737761

COMPLETED NA 18 participants

Hemodynamic Effects of Spironolactone in Patients With Heart Failure

University of Toledo Health Science Campus

NCT00860340

COMPLETED NA 16 participants

EnSite NavX-Guided Coronary Sinus Mapping During CRT Implant

Abbott Medical Devices

NCT01615835

COMPLETED NA 13 participants

Congestive Heart Failure Pilot Study Utilizing Wireless Home Scale and Daily Symptom Monitoring

University of Pennsylvania

NCT03234088

COMPLETED NA 8 participants

A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients

University of New Mexi

NCT00690521

COMPLETED NA 3 participants

Effective Management of Emotional Response to Generate Well-Being Post-HF Exacerbation

Duke University

NCT03043261

Phase Distribution

PhaseTrial count
Early Phase 1 4
Phase 2 5
Phase 3 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Congestive Heart Failure Trial Landscape

ClinicalTrials.gov lists 52 US studies indexed under Congestive Heart Failure, and 8 of those are currently open to recruitment — roughly 15% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Congestive Heart Failure shows 3 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Congestive Heart Failure is led by Abbott Medical Devices with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 52 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Congestive Heart Failure?

PlainTrial tracks 52 US clinical trials for Congestive Heart Failure, of which 8 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Congestive Heart Failure?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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